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Archives of Toxicology

, Volume 68, Issue 5, pp 317–321 | Cite as

Evaluation of mercury in hair, blood and muscle as biomarkers for methylmercury exposure in male and female mice

  • Jesper Bo Nielsen
  • Ole Andersen
  • Philippe Grandjean
Original Investigations

Abstract

Recently established reference intervals demonstrate that blood mercury is significantly higher in women than in men. Mercury in blood and hair are both used as biomarkers for human methylmercury exposure and employed in risk assessment without considering possible sex-related differences in toxicokinetics of methylmercury. In an experimental study using male and female mice of three different strains, the validty of mercury in hair, blood and muscle as indicators of methylmercury exposure was evaluated. Significant sex-related differences in the toxicokinetics of methylmercury were observed in the mice and it is concluded that hair and blood levels of mercury are of questionable relevance as indicators of both body burden and target organ concentrations of mercury. However, blood concentrations might be used as an indicator of brain deposition and the correlation improves after corrections due to sex-related differences in toxicokinetics.

Key words

Methylmercury Biomarkers Sex-related difference Mice 

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References

  1. Grandjean P, Nielsen GD, Jørgensen PJ, Hørder M (1992) Reference intervals for trace elements in blood: significance of risk factors. Scand J Clin Lab Invest 52: 321–337PubMedCrossRefGoogle Scholar
  2. Hirayama K, Yasutake A, Inoue M (1987) Effect of sex hormones on the fate of methylmercury and on glutathione metabolism in mice. Biochem Pharmacol 36[12]: 1919–1924PubMedCrossRefGoogle Scholar
  3. Magos L, Peristianis GC, Clarkson TW, Brown A, Preston S, Snowdon RT (1981) Comparative study of the sensitivity of male and female rats to methylmercury. Arch Toxicol 48: 11–20PubMedCrossRefGoogle Scholar
  4. Mann SJ (1971) Hair loss and cyst formation in hairless and rhino mutant mice. Anat Rec 170: 485–499PubMedCrossRefGoogle Scholar
  5. Morrissey PJ, Parkinson DR, Schwartz RS, Waksal SD (1980) Immunologic abnormalities in HRS/J mice. I. Specific deficit in T lymphocyte helper function in a mutant mouse. J Immunol 1215: 1558–1562Google Scholar
  6. Nielsen JB, Andersen O (1991a) Methyl mercuric chloride toxicokinetics in mice. I: Effects of strain, sex, route of administration and dose. Pharmacol Toxicol 68: 201–207PubMedGoogle Scholar
  7. Nielsen JB, Andersen O (1991b) Methyl mercuric chloride toxicokinetics in mice. II: sexual differences in whole body retention and deposition in blood, hair, skin, muscles and fat. Pharmacol Toxicol 68: 208–211PubMedCrossRefGoogle Scholar
  8. Thomas DJ, Fisher HL, Sumler MR, Marcus AH, Mushak P, Hall LL (1986) Sexual differences in the distribution and retention of organic and inorganic mercury in methyl mercury treated rats. Environ Res 41: 219–234PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • Jesper Bo Nielsen
    • 1
  • Ole Andersen
    • 2
  • Philippe Grandjean
    • 1
  1. 1.Institute of Community HealthOdense UniversityOdense CDenmark
  2. 2.Institute for Life Sciences and ChemistryRoskilde University CenterRoskildeDenmark

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