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Archives of Toxicology

, Volume 74, Issue 4–5, pp 281–283 | Cite as

2-Phenoxyethanol: a neurotoxicant?

  • G. SchmuckEmail author
  • W. Steffens
  • E. Bomhard
Letter to the Editor

Keywords

NMDA NMDA Receptor Muscimol Cortical Spreading Depression Dermal Exposure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Ahmed AE, Farooqui MYH, Upreti RK, El-Shabrawy O (1983) Comparative toxicokinetics of 2:3-14C- and 1-14C-acrylonitrile in the rat. J Appl Toxicol 3: 39–47PubMedCrossRefGoogle Scholar
  2. Akhondzadeh S, Stone TW (1995) Induction of a novel form of hippocampal long-term depression by muscimol: involvement of GABAA but not glutamate receptors. Br J Pharmacol 115: 527–533PubMedCentralPubMedCrossRefGoogle Scholar
  3. Anderson WW, Swartzwelder HS, Wilson WA (1987) The NMDA receptor antagonist 2-amino-5-phosphonovaleriate blocks stimulus train-induced epileptogenesis but not epileptiform bursting in the rat hippocampal slice. J Neurophysiol 57: 1–21PubMedGoogle Scholar
  4. Gean P-W, Jin J-H (1993) D-2-amino-5-phosphonovaleate blocks induction of long-term depression of the NMDA receptor-mediated synaptic component in the rat hippocampus. Neurosci Lett 158: 170–172PubMedCrossRefGoogle Scholar
  5. Gilbert ME, Burdette LJ (1995) Hippocampal field potentials: a model system to characterize neurotoxicity. In: Chang LW, Slikker W (eds) Neurotoxicology. Academic, New York, pp 183–204CrossRefGoogle Scholar
  6. Greim H (ed) (1998) 2-Phenoxyethanol. Toxikologisch-arbeitsmedizinische Begrundungen von MAK-Werten, 26th edn. VCH, WeinheimGoogle Scholar
  7. Hardin BD (1983) Reproductive toxicology of the glycol ethers. Toxicology 27: 91–102PubMedCrossRefGoogle Scholar
  8. Hobson DW, D'Addario AP, Bruner RH, Uddin DE (1986) A subchronic dermal exposure study of diethylene glycol monomethyl ether and ethylene glycol monomethyl ether in the male guinea pig. Fundam Appl Toxicol 6: 339–348PubMedCrossRefGoogle Scholar
  9. Little HJ (1991) Mechanisms that may underlie the behavioral effects of ethanol. Prog Neurobiol 36: 171–194PubMedCrossRefGoogle Scholar
  10. Morton WE (1990) Occupational phenoxyethanol neurotoxicity: a report of three cases. J Occup Med 32: 42–45PubMedCrossRefGoogle Scholar
  11. Mußhoff U, Madeja M, Binding N, Witting U, Speckmann EJ (1999) Effects of 2-phenoxyethanol on N-methyl-d-aspartate (NMDA) receptor-mediated ion currents. Arch Toxicol 73: 55–59PubMedCrossRefGoogle Scholar
  12. Obrenovitch TP, Zilkha E (1996) Inhibition of cortical spreading depression by L-701:324, a novel antagonist at the glycine side of the N-methyl-d-aspartate receptor complex. Br J Pharmacol 117:931–937PubMedCentralPubMedCrossRefGoogle Scholar
  13. Ohi G, Wegman DH (1978) Transcutaneous ethylene glycol monomethyl ether poisoning in the work setting. J Occup Med 20:675–676PubMedGoogle Scholar
  14. Palmer GC, Stagnitto ML, Ray RK, Knowles MA, Harvey R, Garske GE (1993) Anticonvulsant properties of calcium channel blockers in mice: N-methyl-d,l-aspardate- and BAY K 8644-induced convulsions are potently blocked by dihydropyridines. Epilepsia 34: 372–380PubMedCrossRefGoogle Scholar
  15. Parsons CB, Parsons MM (1938) Toxic encephalopathy and granulopenia due to volatile solvents in industry: report of a case. J Ind Hyg Toxicol 20: 124–130Google Scholar
  16. Pick CP, Cooperman M, Trombka D, Rogel-Fuchs, Y, Yanai J (1993) Hippocampal cholinergic alterations and related behavioral deficits after early exposure to ethanol. Int J Dev Neurosci 11: 379–385PubMedCrossRefGoogle Scholar
  17. Rowe VK, Wolf MA (1982) Derivatives of glycols. In: Clayton GD, Clayton FE (eds) Patty's industrial hygiene and toxicology, 3rd edn. Wiley, New York, pp 3911–3919Google Scholar

Copyright information

© Springer-Verlag 2000

Authors and Affiliations

  1. 1.Institute of ToxicologyBayer AGWuppertalGermany
  2. 2.Medical Services, Clinical Toxicology and Product SafetyBayer AGLeverkusenGermany

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