Response to Hethey et al., 2019 letter to the editor in archives of toxicology
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The authors are grateful to Dr. Hethey and his colleagues for their interest in our article entitled “Exploring sex differences in human health risk assessment for PFNA and PFDA using a PBPK model” and their thoughtful comments on them. While their critical comments are deeply appreciated, the authors would like to take this opportunity to write a rebuttal.
First, although Hethey et al. (2019) have pointed out that the PBPK model structure inappropriately reflected renal physiology, this comment was based on calculation errors. Second, they have mentioned that the simple allometric scaling in our PBPK model did not take into consideration of the inter-species and gender differences of kidney transporters which play a key role in the disposition of per- and poly-fluoroalkyl substances (PFASs). However, again, their conclusions were based on misinterpretation of the previous studies.
In point 1, Hethey et al. (2019) have claimed that the PBPK model structure needs to be refined to...
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Conflict of interest
The authors declare that they have no conflict of interest.
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