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Archives of Toxicology

, Volume 93, Issue 3, pp 743–751 | Cite as

Boron-exposed male workers in Turkey: no change in sperm Y:X chromosome ratio and in offspring’s sex ratio

  • Yalçın DuyduEmail author
  • Nurşen Başaran
  • Can Özgür Yalçın
  • Aylin Üstündağ
  • Sevtap Aydın
  • Hatice Gül Anlar
  • Merve Bacanlı
  • Kaan Aydos
  • Cem Somer Atabekoğlu
  • Klaus Golka
  • Katja Ickstadt
  • Tanja Schwerdtle
  • Matthias Werner
  • Hermann M. Bolt
Reproductive Toxicology
  • 165 Downloads

Abstract

Boron-associated shifts in sex ratios at birth were suggested earlier and attributed to a decrease in Y- vs. X-bearing sperm cells. As the matter is pivotal in the discussion of reproductive toxicity of boron/borates, re-investigation in a highly borate-exposed population was required. In the present study, 304 male workers in Bandirma and Bigadic (Turkey) with different degrees of occupational and environmental exposure to boron were investigated. Boron was quantified in blood, urine and semen, and the persons were allocated to exposure groups along B blood levels. In the highest (“extreme”) exposure group (n = 69), calculated mean daily boron exposures, semen boron and blood boron concentrations were 44.91 ± 18.32 mg B/day, 1643.23 ± 965.44 ng B/g semen and 553.83 ± 149.52 ng B/g blood, respectively. Overall, an association between boron exposure and Y:X sperm ratios in semen was not statistically significant (p > 0.05). Also, the mean Y:X sperm ratios in semen samples of workers allocated to the different exposure groups were statistically not different in pairwise comparisons (p > 0.05). Additionally, a boron-associated shift in sex ratio at birth towards female offspring was not visible. In essence, the present results do not support an association between boron exposure and decreased Y:X sperm ratio in males, even under extreme boron exposure conditions.

Keywords

Paternal exposure Boron exposure Y:X chromosome ratio Sex ratio at birth 

Notes

Acknowledgements

The semen samples used in this study were sampled within the scope of the “Boron Project I” (2008–2010) and the “Boron Project II” (2014–2017). The “Boron Project I” was funded by Eti Mine Works General Management and BOREN (2008-G0207). The “Boron Project II” was funded by Eti Mine Works General Management (2014–2017).

Compliance with ethical standards

Conflict of interest

The project was funded by Eti Mine. Eti Mine had no influence on the conduct of the study and has not influenced the results and interpretation. Thus, the authors declare no conflict of interest.

Supplementary material

204_2019_2391_MOESM1_ESM.docx (154 kb)
Supplementary material 1 (DOCX 153 KB)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Yalçın Duydu
    • 1
    Email author
  • Nurşen Başaran
    • 2
  • Can Özgür Yalçın
    • 1
  • Aylin Üstündağ
    • 1
  • Sevtap Aydın
    • 2
  • Hatice Gül Anlar
    • 2
  • Merve Bacanlı
    • 2
  • Kaan Aydos
    • 3
  • Cem Somer Atabekoğlu
    • 4
  • Klaus Golka
    • 7
  • Katja Ickstadt
    • 5
  • Tanja Schwerdtle
    • 6
  • Matthias Werner
    • 5
  • Hermann M. Bolt
    • 7
  1. 1.Faculty of Pharmacy, Department of ToxicologyAnkara UniversityAnkaraTurkey
  2. 2.Faculty of Pharmacy, Department of ToxicologyHacettepe UniversityAnkaraTurkey
  3. 3.Faculty of Medicine, Department of UrologyAnkara UniversityAnkaraTurkey
  4. 4.Faculty of Medicine, Department of Gynecology and ObstetricsAnkara UniversityAnkaraTurkey
  5. 5.Faculty of StatisticsTU Dortmund UniversityDortmundGermany
  6. 6.Institute of Nutritional Science, Department of Food ChemistryUniversity of PotsdamNuthetalGermany
  7. 7.Leibniz Research Center for Working Environment and Human Factors (IfADo)DortmundGermany

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