Comment on ‘Perinatal exposure to a glyphosate-based herbicide impairs female reproductive outcomes and induces second-generation adverse effects in Wistar rats’, Arch Toxicol 92:2629–2643
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Recently, Milesi et al. (2018) described that the exposure of female rats (F0) to a glyphosate-based herbicide (GBH, 2 and 200 mg of glyphosate/kg bwt/day via diet) during pregnancy (from GD 9 on), parturition and lactation up to weaning (PND 21), increased the rate of preimplantation losses in the F1 offspring. Moreover, they noted adverse effects of GBH on the prenatal development of the second-generation conceptuses (F2), such as intrauterine growth retardation and 03 fetuses with externally visible congenital anomalies. Some methodological issues, however, raise serious questions as to whether prenatal and lactation exposure to GBH did in fact impair the reproductive performance of female rats.
The conclusion that GBH increased the number of preimplantation losses in F1 females, for instance, may not be true. According to the authors, the number of implantation sites (IS) was “the total number of placentas with fetuses plus the total number of resorptions”, and resorptions were...
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Conflict of interest
The author declares that he has no conflict of interest.
- Milesi MM, Lorenz V, Pacini G, Repetti MR, Demonte LD, Varayoud J, Luque EH (2018) Perinatal exposure to a glyphosate-based herbicide impairs female reproductive outcomes and induces second-generation adverse effects in Wistar rats. Arch Toxicol 92(8):2629–2643. https://doi.org/10.1007/s00204-018-2236-6 CrossRefGoogle Scholar