Response to Uptake of microplastics and related health effects: a critical discussion of Deng et al., Scientific reports 7: 46687, 2017
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We would like to thank Dr. Braeuning and other potential readers for their interests in our paper named “Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure” (Deng et al. 2017). After carefully reviewing the critical discussion (Braeuning 2018), there are two main concerns in regard to whether microplastics used in our study could enter mouse tissues and the biomarkers including serum metabolites and tissue histological changes were appropriate to elucidate the biological responses induced by microplastics. We try to respond to these concerns by elucidating the following scientific questions:
How could big microplastics enter mammal tissues?
Although the European Food Safety Agency (EFSA) claimed the particles with sizes over 1.5 µm may not cross the mammalian intestinal barrier and cannot subsequently distribute in other tissues (Chain 2016), we really think this is an immature conclusion. Because several valuable...
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