MicroRNAs in the diagnosis and prevention of drug-induced cardiotoxicity
- 200 Downloads
Drug-induced cardiotoxicity is a serious problem associated with the administration of many drugs. MicroRNAs (miRNAs) have been reported to be affected by drugs and other xenobiotics, and the potential of miRNAs as biomarkers and diagnostic tools has been considered. In recent years, an association of certain miRNAs with the cardiotoxicity of some drugs, namely anthracyclines, bevacizumab, cyclosporine A and isoprenaline, has already been found. This review article summarizes available information about the changes in miRNA levels induced by cardiotoxic drugs. Three aspects are discussed: the altered expression of miRNAs in the heart upon treatment with cardiotoxic drugs, circulating miRNAs as promising early biomarkers of cardiotoxicity, and the potential of miRNAs in the prevention and/or attenuation of drug-induced cardiotoxicity. The targeted changes in the level of certain miRNAs by antagomiRs and miRNA mimics are also described and evaluated. In addition, the cardioprotective mechanism of various natural compounds via their effect on miRNA levels are examined.
KeywordsCardiotoxicity Circulating microRNA Biomarkers Doxorubicin
This project was supported by the Grant Agency of Charles University, Grant no. 814316 and by the Charles University in Prague (Research Project SVV 260 416). This work was supported by the project EFSA-CDN (No. CZ.02.1.01/0.0/0.0/16_019/0000841) and co-funded by ERDF.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
- Leger KJ, Leonard D, Nielson D, de Lemos JA, Mammen PPA, Winick NJ (2017) Circulating microRNAs: potential markers of cardiotoxicity in children and young adults treated with anthracycline chemotherapy. J Am Heart Assoc 6(4):e004653. https://doi.org/10.1161/jaha.116.004653 CrossRefPubMedPubMedCentralGoogle Scholar
- Moutinho C, Esteller M (2017) MicroRNAs and epigenetics. In: Croce CM, Fisher PB (eds) Mirna and cancer. Advances in Cancer Research, vol 135, pp 189–220Google Scholar
- Tabernero J, Brana I (2011) Cardiotoxicity induced by anticancer drugs. EJHP Pract 17(6):5–7Google Scholar