Comment on Sjögren et al. (2018) A novel multi-parametric high-content screening assay in ciPTEC-OAT1 to predict drug-induced nephrotoxicity in drug discovery. Arch Toxicol 92(10):3175–3190

  • Daniele Zink
Letter to the Editor, News and Views


Rapid progress is made in the development of high-content screening assays for the prediction of nephrotoxicity. The findings from different laboratories are consistent with respect to endpoints and concentration ranges screened. Discrepancies regarding compound annotation and the predictive performance analysis are discussed.



This work was supported by the Institute of Bioengineering and Nanotechnology (A*STAR, Singapore).

Compliance with ethical standards

Conflict of interest

The author declares that she has no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Institute of Bioengineering and NanotechnologySingaporeSingapore

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