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Archives of Toxicology

, Volume 93, Issue 1, pp 11–24 | Cite as

The history of poisoning: from ancient times until modern ERA

  • Eugenie Nepovimova
  • Kamil KucaEmail author
Review Article

Abstract

The history of poisoning is one of the greatest chapters of the human history, where curiosity and genius, scientific discoveries and empirical knowledge intertwine with intrigues, crimes, politics, personal tragedies of notabilities, wars and natural disasters. Knowledge of toxic substances is likely as old as the mankind. In the Middle Age, Paracelsus claimed that in the world there is no non-toxic substance that the therapeutic and toxic properties of substances are indistinguishable up to a single parameter—dose. This postulate still belongs among the basic pillars of modern toxicology. Probably, the most ancient way of killing people was poisoning. In addition, the presence of poison in the body of the victim was very difficult to determine, since the symptoms of poisoning were similar to signs of certain diseases. Therefore, the criminals had a big chance to escape the punishment. Nowadays, together with development of toxicology the chance of disclosure of such crimes has increased, however, the progress in the field of design and production of toxic substances has also gone up. Within current contribution we have reviewed the most famous historical cases of poisoning from the antiquity to the present.

Keywords

History Poisoning Toxicology Poison 

Notes

Acknowledgements

This work was supported by the project Excellence of the University of Hradec Kralove and Long-term development plan of UHK.

References

  1. Aveline J (2004) The death of claudius. Hist Z Für Alte Gesch 53:453–475Google Scholar
  2. BBC News (2018) Russian spy: Highly likely Moscow behind attack, says Theresa May. https://www.bbc.co.uk/news/uk-43377856.html. Accessed 12 Jul 2018
  3. Birstein DVJ (2009) The perversion of knowledge: the true story of soviet science. Westview Press, Cambridge, MA, USAGoogle Scholar
  4. Bisset NG (1992) War and hunting poisons of the New World. Part 1. Notes on the early history of curare. J Ethnopharmacol 36:1–26.  https://doi.org/10.1016/0378-8741(92)90056-W CrossRefGoogle Scholar
  5. Borowitz A (2005) Salieri and the Murder of Mozart. Leg Stud Forum 29:923Google Scholar
  6. Borzelleca JF (2000) Paracelsus: herald of modern toxicology. Toxicol Sci 53:2–4.  https://doi.org/10.1093/toxsci/53.1.2 CrossRefGoogle Scholar
  7. Cilliers L, Retief FP (2014) Poisons, poisoning and the drug trade in ancient Rome. Akroterion.  https://doi.org/10.7445/45-0-166 Google Scholar
  8. Clauss JJ (2013) Nikander of Kolophon. The encyclopedia of ancient history. Blackwell Publishing Ltd., USAGoogle Scholar
  9. Corso PF, Hindmarsh JT, Stritto FD (2000) The death of Napoleon. Am J Forensic Med Pathol 21:300CrossRefGoogle Scholar
  10. Crompton R, Gall D (1980) Georgi Markov—Death in a Pellet. Med Leg J 48:51–62.  https://doi.org/10.1177/002581728004800203 CrossRefGoogle Scholar
  11. Dumas A (2016) Queen Margot (Unabridged): historical novel—the story of court intrigues. Bloody battle for the throne and wars of religion. e-artnow, PragueGoogle Scholar
  12. Dupouy-Camet J (2002) Trichinellosis is unlikely to be responsible for Mozart’s Death. Arch Intern Med 162:946–946CrossRefGoogle Scholar
  13. Emery AEH (2013) Hippocrates and the oath. J Med Biogr 21:198–199.  https://doi.org/10.1177/0967772013513395 CrossRefGoogle Scholar
  14. Fielding J (2017) Suspected assassin of Kim Jong-nam thought she was in a TV prank|World|News|Express.co.uk. https://www.express.co.uk/news/world/772082/kim-jong-nam-assassin-murder-tv-prank-baby-oil-north-korea. Accessed 5 Jun 2018
  15. Frey EF (1985) The earliest medical texts. Clio Med Amst Neth 20:79–90Google Scholar
  16. Froidevaux P, Bochud F, Baechler S et al (2016) 210Po poisoning as possible cause of death: forensic investigations and toxicological analysis of the remains of Yasser Arafat. Forensic Sci Int 259:1–9.  https://doi.org/10.1016/j.forsciint.2015.09.019 CrossRefGoogle Scholar
  17. Fuhrmann JT (2012) Rasputin: the untold story, 1 edition. Wiley, HobokenGoogle Scholar
  18. Gander K (2016) How polonium-210 killed Russian dissident Alexander Litvinenko. In: The Independent. http://www.independent.co.uk/life-style/health-and-families/health-news/alexander-litvinenko-what-does-polonium-do-to-the-body-inquiry-andrei-lugovoi-and-dmitri-kovtun-a6824811.html. Accessed 5 Jun 2018
  19. Goeschel C (2009) Suicide in Nazi Germany. Oxford University Press, OxfordGoogle Scholar
  20. Goldfarb A (2010) Death of a dissident: the poisoning of Alexander Litvinenko and the return of the KGB. Simon and Schuster, New YorkGoogle Scholar
  21. Gough M (2013) Dioxin, agent orange: The facts. Springer, HeidelbergGoogle Scholar
  22. Grell OP (1998) Paracelsus. BRILL, AylesburyGoogle Scholar
  23. Griffin JP (1995) Famous names in toxicology. Mithridates VI of Pontus, the first experimental toxicologist. Adverse Drug React Toxicol Rev 14:1–6Google Scholar
  24. Halamek E, Kobliha Z (2011) Potential chemical warfare agents. Chem Listy 105:323–333Google Scholar
  25. Harkup K (2017) Poisoned, shot and beaten: why cyanide alone may have failed to kill Rasputin. https://www.theguardian.com/science/blog/2017/jan/13/poisoned-shot-and-beaten-why-cyanide-may-have-failed-to-kill-rasputin. Accessed 20 Aug 2018
  26. Harrison J, Leggett R, Lloyd D et al (2007) Polonium-210 as a poison. J Radiol Prot 27:17.  https://doi.org/10.1088/0952-4746/27/1/001 CrossRefGoogle Scholar
  27. Hindmarsh JT, Corso PF (1998) The death of Napoleon Bonaparte: a critical review of the cause. J Hist Med Allied Sci 53:201–218.  https://doi.org/10.1093/jhmas/53.3.201 CrossRefGoogle Scholar
  28. Hirschmann JV (2001) What Killed Mozart? Arch Intern Med 161:1381–1389.  https://doi.org/10.1001/archinte.161.11.1381 CrossRefGoogle Scholar
  29. Holdsworth N (2013) Prime suspect in Georgi Markov “umbrella poison” murder tracked down to Austria. https://www.telegraph.co.uk/news/uknews/crime/9949856/Prime-suspect-in-Georgi-Markov-umbrella-poison-murder-tracked-down-to-Austria.html. Accessed 5 Jun 2018
  30. Hotti H, Rischer H (2017) The killer of socrates: coniine and related alkaloids in the plant Kingdom. Mol Basel Switz.  https://doi.org/10.3390/molecules22111962 Google Scholar
  31. Kruse E (2003) The woman in black: the image of catherine de medici from Marlowe to Queen Margot. In: “High and Mighty Queens” of early modern England: realities and representations. Palgrave Macmillan, New York, pp 223–237CrossRefGoogle Scholar
  32. Lin X, Alber D, Henkelmann R (2004) Elemental contents in Napoleon’s hair cut before and after his death: did Napoleon die of arsenic poisoning? Anal Bioanal Chem 379:218–220.  https://doi.org/10.1007/s00216-004-2536-y CrossRefGoogle Scholar
  33. Macinnis P (2005) Poisons: from hemlock to botox to the killer Bean of Calabar, first edition edition. Arcade Publishing, New YorkGoogle Scholar
  34. Marmion VJ, Wiedemann TEJ (2002) The death of Claudius. J R Soc Med 95:260–261CrossRefGoogle Scholar
  35. McFee RB, Leikin JB (2009) Death by Polonium-210: lessons learned from the murder of former Soviet spy Alexander Litvinenko. Semin Diagn Pathol 26:61–67.  https://doi.org/10.1053/j.semdp.2008.12.003 CrossRefGoogle Scholar
  36. Mirzayanov V (2008) State secrets: an insider´s chronicle of the Russian chemical weapons program. Outskirts Press, USAGoogle Scholar
  37. Neuwinger HD (1996) African ethnobotany: poisons and drugs: chemistry, pharmacology, toxicology. CRC Press, Boca RatonGoogle Scholar
  38. O’Brien JM (2003) Alexander the great: the invisible enemy: a biography. Routledge, AbingdonGoogle Scholar
  39. Obodovskiy I (2015) Fundamentals of radiation and chemical safety. Elsevier, New YorkGoogle Scholar
  40. Paddock RC, Sang-Hun C (2017) Kim Jong-nam Was Killed by VX Nerve Agent, Malaysians Say—The New York Times. In: N. Y. Times. https://www.nytimes.com/2017/02/23/world/asia/kim-jong-nam-vx-nerve-agent-.html. Accessed 30 May 2018
  41. Papaloucas M, Papaloucas C, Stergioulas A (2008) Ricin and the assassination of Georgi Markov. Pak J Biol Sci 11:2370–2371.  https://doi.org/10.3923/pjbs.2008.2370.2371 CrossRefGoogle Scholar
  42. Parascandola J (2012) King of poisons: a history of arsenic. Potomac Books, WashingtonGoogle Scholar
  43. Payne R, Romanoff N (2002) Ivan the Terrible. Rowman & Littlefield, LanhamGoogle Scholar
  44. Phillips G (2012) Alexander the great. Ebury Publishing, LondonGoogle Scholar
  45. Prozorovskiĭ VI, Kolosova VM (1970) Some data from spectral studies on the bone tissue of Tzar Ivan IV, his sons and Prince Skopin-Shuĭskiĭ. Sud Med Ekspert 13:7–11Google Scholar
  46. Saurat J-H, Kaya G, Saxer-Sekulic N et al (2012) The cutaneous lesions of dioxin exposure: lessons from the poisoning of victor Yushchenko. Toxicol Sci 125:310–317.  https://doi.org/10.1093/toxsci/kfr223 CrossRefGoogle Scholar
  47. Schecter A, Dai LC, Thuy LT et al (1995) Agent Orange and the Vietnamese: the persistence of elevated dioxin levels in human tissues. Am J Public Health 85:516–522.  https://doi.org/10.2105/AJPH.85.4.516 CrossRefGoogle Scholar
  48. Scheidt W (1967) Mercury poisoning in Mozart, Beethoven and Schubert? Med Klin Urban Schwarz 62:195–196Google Scholar
  49. Scheindlin S (2010) Episodes in the story of physostigmine. Mol Interv 10:4–10.  https://doi.org/10.1124/mi.10.1.1 CrossRefGoogle Scholar
  50. Shotter D (2014) Nero Caesar Augustus: Emperor of Rome. Routledge, AbingdonGoogle Scholar
  51. Smith S (1954) Poisoning and poisoners. Br Med J 2:1212CrossRefGoogle Scholar
  52. Somerset A (2004) The Affair of the Poisons: Murder, Infanticide and Satanism at the Court of Louis XIV. Phoenix, LondonGoogle Scholar
  53. Sorg O, Zennegg M, Schmid P et al (2009) 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) poisoning in Victor Yushchenko: identification and measurement of TCDD metabolites. The Lancet 374:1179–1185.  https://doi.org/10.1016/S0140-6736(09)60912-0 CrossRefGoogle Scholar
  54. Tsuchihashi H, Katagi M, Nishikawa M, Tatsuno M (1998) Identification of metabolites of nerve agent VX in serum collected from a victim. J Anal Toxicol 22:383–388CrossRefGoogle Scholar
  55. Tu AT (1999) Overview of sarin terrorist attacks in Japan. In: Tu AT, Gaffield W (eds) Natural and selected synthetic toxins. American Chemical Society, Washington DC, pp 304–317CrossRefGoogle Scholar
  56. Vaksberg A (2011) Toxic Politics: The Secret History of the Kremlin’s Poison Laboratory–from the Special Cabinet to the Death of Litvinenko. ABC-CLIOGoogle Scholar
  57. Vale A (2005) What lessons can we learn from the Japanese sarin attacks? Przegl Lek 62:528–532Google Scholar
  58. Valle G, Stanislao M, Facciorusso A et al (2009) Mithridates VI Eupator, father of the empirical toxicology. Clin Toxicol Phila Pa 47:433.  https://doi.org/10.1080/15563650902899144 CrossRefGoogle Scholar
  59. Valle G, Carmignani M, Stanislao M et al (2012) Mithridates VI Eupator of Pontus and mithridatism. Allergy 67:138–139.  https://doi.org/10.1111/j.1398-9995.2011.02700.x CrossRefGoogle Scholar
  60. Wasson RG (1972) The death of Claudius or mushrooms for murderers. Bot Mus Leafl Harv Univ 23:101–128Google Scholar
  61. Wexler P (2017) Toxicology in the middle ages and renaissance. Academic Press Elsevier, LondonGoogle Scholar
  62. Whyte IM (2001) Clinical toxicology: One man’s poison. Emerg Med 12:11–13.  https://doi.org/10.1046/j.1442-2026.2000.00089.x CrossRefGoogle Scholar
  63. Wiener SW, Hoffman RS (2004) Nerve agents: a comprehensive review. J Intensive Care Med 19:22–37.  https://doi.org/10.1177/0885066603258659 CrossRefGoogle Scholar
  64. Yanagisawa N, Morita H, Nakajima T et al (1995) Sarin poisoning in Matsumoto, Japan. The Lancet 346:290–293.  https://doi.org/10.1016/S0140-6736(95)92170-2 CrossRefGoogle Scholar
  65. Zemskova EY, Kvacheva YE, Kovalev AV, Ivanov PL (2015) The death of Yasser Arafat: molecular-genetic authentication of the remains as an indispensable condition for the evaluation of the medical hypotheses of the cause of his death. Sud Med Ekspert 58:4–13.  https://doi.org/10.17116/sudmed20155864-13 CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Chemistry, Faculty of ScienceUniversity of Hradec KraloveHradec KraloveCzech Republic
  2. 2.Faculty of PhilosophyUniversity of Hradec KraloveHradec KraloveCzech Republic

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