Obesogenic endocrine disruptors and obesity: myths and truths
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Obesogenic endocrine disruptors, also known as obesogens, are chemicals potentially involved in weight gain by altering lipid homeostasis and promoting adipogenesis and lipid accumulation. They included compounds to which human population is exposed over daily life such as pesticides/herbicides, industrial and household products, plastics, detergents and personal care products. The window of life during which the exposure happens could lead to different effects. A critical window is during utero and/or neonatal period in which the obesogens could cause subtle changes in gene expression and tissue organization or blunt other levels of biological organization leading to increased susceptibility to diseases in the adulthood. Some of the reasons for this increased sensitivity include the lack of the protective mechanisms that are available in adult such as DNA repair mechanisms, a competent immune system, detoxifying enzymes, liver metabolism and the blood/brain barrier still not fully functional in the fetus or newborn. The mechanisms of action of obesogens lay on their ability to increase the number and/or the size of the adipocytes and to alter appetite, satiety and food preferences. The ability of obesogens to increase fat deposition results in an increased capacity for their own retention due to their lipophilic properties; thus prolonging the exposure and increasing the detrimental metabolic consequences.
KeywordsObesity Phthalates Bisphenol A Diethylstilbestrol Polycyclic aromatic hydrocarbons Organic pollutants Environment Tributyltin
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Conflict of interest
The authors declare that there are no conflicts of interest, neither any grants nor other financial supports regarding the publication of this article.
- Behl M, Rao D, Aagaard K, Davidson TL, Levin ED, Slotkin TA et al (2013) Evaluation of the association between maternal smoking, childhood obesity, and metabolic disorders: a national toxicology program workshop review. Environ Health Perspect 121:170–180. doi: 10.1289/ehp.1205404 PubMedGoogle Scholar
- Feige JN, Gelman L, Rossi D, Zoete V, Métivier R, Tudor C, Anghel SI, Grosdidier A, Lathion C, Engelborghs Y, Michielin O, Wahli W, Desvergne B (2007) The endocrine disruptor monoethyl-hexyl-phthalate is a selective peroxisome proliferator-activated receptor gamma modulator that promotes adipogenesis. J Biol Chem 282:19152–19166CrossRefPubMedGoogle Scholar
- Hatch EE, Nelson JW, Qureshi MM, Weinberg J, Moore LL et al (2008) Association of urinary phthalate metabolite concentrations with body mass index and waist circumference: a cross-sectional study of NHANES data, 1999–2002. Environ Health 7:27. doi: 10.1186/1476-069X-7-27 CrossRefPubMedPubMedCentralGoogle Scholar
- Hugo ER, Brandebourg TD, Woo JG, Loftus J, Alexander JW, Ben-Jonathan N (2008) Bisphenol A at environmentally relevant doses inhibits adiponectin release from human adipose tissue explants and adipocytes. Environ Health Perspect 116:1642–1647. doi: 10.1289/ehp.1153749 CrossRefPubMedPubMedCentralGoogle Scholar
- Kanayama T, Kobayashi N, Mamiya S, Nakanishi T, Nishikawa J (2005) Organotin compounds promote adipocyte differentiation as agonists of the peroxisome proliferator-activated receptor gamma/retinoid X receptor pathway. Mol Pharmacol 67:766–774. doi: 10.1124/mol.104.008409 CrossRefPubMedGoogle Scholar
- Stahlhut RW, Van Wijngaarden E, Dye TD, Cook S, Swan SH (2007) Concentrations of urinary phthalate metabolites are associated with increased waist circumference and insulin resistance in adult U.S. males. Environ Health Perspect 115:876–882. doi: 10.1289/ehp.9882 CrossRefPubMedPubMedCentralGoogle Scholar
- Strakovsky RS, Lezmi S, Shkoda I, Flaws JA, Helferich WG, Pan YX (2015) In utero growth restriction and catch-up adipogenesis after developmental di(2-ethylhexyl) phthalate exposure cause glucose intolerance in adult male rats following a high-fat dietary challenge. J Nutr Biochem 26:1208–1220. doi: 10.1016/j.jnutbio.2015.05.012 CrossRefPubMedPubMedCentralGoogle Scholar
- Xue J, Wu Q, Sakthivel S, Pavithran PV, Vasukutty JR, Kannan K (2015) Urinary levels of endocrine-disrupting chemicals, including bisphenols, bisphenol A diglycidyl ethers, benzophenones, parabens, and triclosan in obese and non-obese Indian children. Environ Res 137:120–128. doi: 10.1016/j.envres.2014.12.007 CrossRefPubMedGoogle Scholar
- Yan Z, Zhang H, Maher C, Arteaga-Solis E, Champagne FA, Wu L et al (2014) Prenatal polycyclic aromatic hydrocarbon, adiposity, peroxisome proliferator-activated receptor (PPAR) γ methylation in offspring, grand-offspring mice. PLoS One 9:e110706. doi: 10.1371/journal.pone.0110706 CrossRefPubMedPubMedCentralGoogle Scholar