A review of drug-induced liver injury databases
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Drug-induced liver injuries have been a major focus of current research in drug development, and are also one of the major reasons for the failure and withdrawal of drugs in development. Drug-induced liver injuries have been systematically recorded in many public databases, which have become valuable resources in this field. In this study, we provide an overview of these databases, including the liver injury-specific databases LiverTox, LTKB, Open TG-GATEs, LTMap and Hepatox, and the general databases, T3DB, DrugBank, DITOP, DART, CTD and HSDB. The features and limitations of these databases are summarized and discussed in detail. Apart from their powerful functions, we believe that these databases can be improved in several ways: by providing the data about the molecular targets involved in liver toxicity, by incorporating information regarding liver injuries caused by drug interactions, and by regularly updating the data.
KeywordsReview Databases Drug-induced liver injury Hepatotoxicity Liver toxicity
We would like to thank Dr. Hongdong Li for his useful discussions, comments and suggestions throughout this entire work. The authors acknowledge financial support from the Nature Foundation Committee of China (No. 31300819).
Conceived and designed the review: ZX and AL. Wrote the paper: GL, YS and LY.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
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