Archives of Toxicology

, Volume 89, Issue 10, pp 1681–1693 | Cite as

Dual effect of red wine on liver redox status: a concise and mechanistic review

  • Paula Silva
  • Eduarda Fernandes
  • Félix Carvalho
Review Article


Chronic ethanol consumption is a strong risk factor for the development of liver disease. Multiple mechanisms are involved in ethanol-mediated liver injury; oxidative stress being pointed has an important factor. However, it should be noted that moderate consumption of red wine has been associated with hepatoprotective effects, mainly due to the antioxidant effect of resveratrol, one of its polyphenolic compounds. In this paper, the potential molecular mechanisms through which the protective effects of resveratrol counteract the oxidative effect of ethanol and the way as this dual effect impacts liver oxidative stress are reviewed. Mechanistic evaluation of modulation of oxidative signaling pathways by ethanol and resveratrol may explain the pathogenesis of various liver diseases and ultimately to disclose possible pharmacological therapies.


Wine Ethanol Resveratrol Liver Redox signaling Oxidative stress 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.UCIBIO-REQUIMTE, Laboratory of Histology and Embryology, Institute of Biomedical Sciences Abel Salazar (ICBAS)University of PortoPortoPortugal
  2. 2.UCIBIO-REQUIMTE, Department of Chemical Sciences, Faculty of PharmacyUniversity of PortoPortoPortugal
  3. 3.UCIBIO-REQUIMTE, Department of Biological Sciences, Laboratory of Toxicology, Faculty of PharmacyUniversity of PortoPortoPortugal

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