MicroRNAs as regulators of airborne pollution-induced lung inflammation and carcinogenesis
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The increasing incidence of pulmonary inflammation and lung cancer, as well as exacerbation of pre-existing chronic lung diseases by exposure to airborne pollutants, e.g., particulate matter and cigarette smoke, is becoming a major public health concern in the world. However, the exact mechanisms of pulmonary injury from exposure to these airborne insults have not been fully elucidated. Nevertheless, accumulating evidence suggests that microRNAs (miRNAs) may play a unique role in the regulation of airborne agent-induced lung inflammation and carcinogenesis. Since epigenetic modifications are heritable and reversible, this may provide a new insight into the relationship of miRNAs and environmental pollution-related lung disorders. The aim of this review was to update our existing knowledge regarding the mechanisms by which airborne pollutants altering miRNA profiles in the lung, specifically for cigarette smoke and airborne particulate matter, and the potential biological roles of miRNAs in the initiation of pulmonary inflammation and lung cancer, as well as the regulation of underlying genetic susceptibility to these environmental stressors.
KeywordsAir pollution Epigenetic modification Lung cancer Lung inflammation MicroRNA
This work was supported by grants from the National Natural Science Foundation of China (Nos. 31172278 and 31472191 to XL).
- Halappanavar S, Jackson P, Williams A et al (2011) Pulmonary response to surface-coated nanotitanium dioxide particles includes induction of acute phase response genes, inflammatory cascades, and changes in microRNAs: a toxicogenomic study. Environ Mol Mutagen 52(6):425–439. doi: 10.1002/em.20639 CrossRefPubMedCentralPubMedGoogle Scholar
- IARC (2013) Outdoor air pollution a leading environmental cause of cancer deaths. The International Agency for Research on Cancer. http://www.iarc.fr/en/mediacentre/pr/2013/pdfs/pr221_E.pdf
- Izzotti A, Calin GA, Arrigo P, Steele VE, Croce CM, De Flora S (2009a) Downregulation of microRNA expression in the lungs of rats exposed to cigarette smoke. FASEB J official publication of the Federation of American Societies for Experimental Biology 23(3):806–812. doi: 10.1096/fj.08-121384 CrossRefGoogle Scholar
- Izzotti A, Calin GA, Steele VE, Croce CM, De Flora S (2009b) Relationships of microRNA expression in mouse lung with age and exposure to cigarette smoke and light. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 23(9):3243–3250. doi: 10.1096/fj.09-135251 CrossRefGoogle Scholar
- Izzotti A, Balansky R, D’Agostini F et al (2013) Relationships between pulmonary micro-RNA and proteome profiles, systemic cytogenetic damage and lung tumors in cigarette smoke-exposed mice treated with chemopreventive agents. Carcinogenesis 34(10):2322–2329. doi: 10.1093/carcin/bgt178 CrossRefPubMedCentralPubMedGoogle Scholar
- Kalscheuer S, Zhang X, Zeng Y, Upadhyaya P (2008) Differential expression of microRNAs in early-stage neoplastic transformation in the lungs of F344 rats chronically treated with the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Carcinogenesis 29(12):2394–2399. doi: 10.1093/carcin/bgn209 CrossRefPubMedCentralPubMedGoogle Scholar
- Song Q, Christiani DC, Wang Xiaorong, Ren J (2014) The global contribution of outdoor air pollution to the incidence, prevalence, mortality and hospital admission for chronic obstructive pulmonary disease: a systematic review and meta-analysis. Int J Environ Res Pub Health 11(11):11822–11832. doi: 10.3390/ijerph111111822 CrossRefGoogle Scholar
- Wilker EH, Baccarelli A, Suh H, Vokonas P, Wright RO, Schwartz J (2010) Black carbon exposures, blood pressure, and interactions with single nucleotide polymorphisms in microRNA processing genes. Environ Health Perspect 118(7):943–948. doi: 10.1289/ehp.0901440 CrossRefPubMedCentralPubMedGoogle Scholar
- Wong CM, Vichit-Vadakan N, Vajanapoom N et al (2010) Part 5. Public health and air pollution in Asia (PAPA): a combined analysis of four studies of air pollution and mortality. Res Rep 154:377–418Google Scholar
- Zhao Y, Xu Y, Li Y et al (2013) NF-kappaB-mediated inflammation leading to EMT via miR-200c is involved in cell transformation induced by cigarette smoke extract. Toxicological sciences: an official journal of the Society of Toxicology 135(2):265–276. doi: 10.1093/toxsci/kft150 CrossRefGoogle Scholar