Archives of Toxicology

, Volume 88, Issue 10, pp 1803–1853 | Cite as

Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update

  • Ana Rodriguez-Mateos
  • David Vauzour
  • Christian G. Krueger
  • Dhanansayan Shanmuganayagam
  • Jess Reed
  • Luca Calani
  • Pedro Mena
  • Daniele Del Rio
  • Alan CrozierEmail author
Review Article


There is substantial interest in the role of plant secondary metabolites as protective dietary agents. In particular, the involvement of flavonoids and related compounds has become a major topic in human nutrition research. Evidence from epidemiological and human intervention studies is emerging regarding the protective effects of various (poly)phenol-rich foods against several chronic diseases, including neurodegeneration, cancer and cardiovascular diseases. In recent years, the use of HPLC–MS for the analysis of flavonoids and related compounds in foods and biological samples has significantly enhanced our understanding of (poly)phenol bioavailability. These advancements have also led to improvements in the available food composition and metabolomic databases, and consequently in the development of biomarkers of (poly)phenol intake to use in epidemiological studies. Efforts to create adequate standardised materials and well-matched controls to use in randomised controlled trials have also improved the quality of the available data. In vitro investigations using physiologically achievable concentrations of (poly)phenol metabolites and catabolites with appropriate model test systems have provided new and interesting insights on potential mechanisms of actions. This article will summarise recent findings on the bioavailability and biological activity of (poly)phenols, focusing on the epidemiological and clinical evidence of beneficial effects of flavonoids and related compounds on urinary tract infections, cognitive function and age-related cognitive decline, cancer and cardiovascular disease.


Dietary flavonoids Related compounds Absorption Metabolism Colonic catabolism Bioactivity Urinary tract infections Neurogenerative disorders Cancer Cardiovascular disease 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Ana Rodriguez-Mateos
    • 1
  • David Vauzour
    • 2
  • Christian G. Krueger
    • 3
  • Dhanansayan Shanmuganayagam
    • 3
  • Jess Reed
    • 3
  • Luca Calani
    • 4
  • Pedro Mena
    • 4
  • Daniele Del Rio
    • 4
  • Alan Crozier
    • 5
    Email author
  1. 1.Division of Cardiology, Pulmonology and Vascular Medicine, Medical FacultyUniversity of DuessseldorfDuesseldorfGermany
  2. 2.Norwich Medical School, Faculty of Medicine and Health SciencesUniversity of East AngliaNorwichUK
  3. 3.Department of Animal SciencesUniversity of Wisconsin-MadisonMadisonUSA
  4. 4.LS9 Bioactives and Health Interlab Group and Human Nutrition Unit, Department of Food ScienceUniversity of ParmaParmaItaly
  5. 5.Department of Nutrition, 3143 Meyer Hall, One Shields AvenueUniversity of CaliforniaDavisUSA

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