Reply to comment of John M. DeSesso and Amy L. Williams regarding “Glyphosate impairs male offspring reproductive development by disrupting gonadotropin expression” by Romano et al. 2012
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The product used in our study was a commercial formulation of glyphosate Roundup Transorb (Monsanto, Brazil). In previous studies, we and other colleagues used different commercial formulations and observed a reduction in testosterone concentrations or reduction in StAR protein expression (Benachour et al. 2007; Benachour and Seralini 2009; Dallegrave et al. 2007; Gasnier et al. 2009; Richard et al. 2005; Romano et al. 2010; Walsh et al. 2000). The reduction in serum testosterone concentration was also observed in drakes exposed to a commercial formulation of glyphosate (Oliveira et al. 2007). Recently, it was observed that both glyphosate salt and a commercial formulation were able to reduce the testosterone production in 35 % (Clair et al. 2012).
Based on this, we proposed to investigate the effect of the reduction in the testosterone during the fetal and postnatal development, which is recognized as the hypothalamic sexual differentiation phase. The dams were exposed to the product...
KeywordsTestosterone Glyphosate Male Offspring Commercial Formulation Material Safety Data Sheet
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