Elevated risk of hypertension induced by arsenic exposure in Taiwanese rural residents: possible effects of manganese superoxide dismutase (MnSOD) and 8-oxoguanine DNA glycosylase (OGG1) genes
- 351 Downloads
Heavy metals, including arsenic and lead, may lead to cellular oxidative damage that is linked to hypertension. Manganese superoxide dismutase (MnSOD) is a scavenger of reactive oxygen species, and 8-oxoguanine DNA glycosylase (OGG1) is the major glycosylase that repairs DNA lesions. Interestingly, whether there is an elevated risk of hypertension with arsenic or lead exposure in individuals with genetic variations in MnSOD or OGG1 has not yet been investigated. Questionnaires were administered to 240 Taiwanese rural residents. Blood pressure and biochemical indicators were assessed in each subject. Urinary levels of arsenic and lead were measured with atomic absorption spectrometry; and MnSOD and OGG1 genotypes were identified via polymerase chain reaction. There was a dose–response relationship between urinary arsenic levels and risk of hypertension (P = 0.021, test for trend). However, there was no association between urinary lead levels and hypertension risk. Individuals with high urinary arsenic levels and the MnSOD Val–Ala/Ala–Ala genotypes had a greater risk of hypertension than those with low urinary arsenic levels and the MnSOD Val–Val genotype (odds ratio [OR] = 4.2, 95% confidence interval [CI] = 1.7–10.3). Subjects with a high urinary arsenic level and the OGG1 Cys–Cys genotype also had a greater risk of hypertension than those with a low urinary arsenic level and the OGG1 Ser–Ser/Ser–Cys genotypes (OR = 3.4, 95% CI = 1.1–10.7). Thus, both MnSOD and OGG1 genotypes may be prone to an increased risk of hypertension associated with arsenic exposure.
KeywordsHypertension Arsenic Lead MnSOD gene OGG1 gene
This study was supported by a grant from Chung Shan Medical University Hospital (CSH-2010-C-11).
- Fujimoto H, Taguchi J, Imai Y, Ayabe S, Hashimoto H, Kobayashi H, Ogasawara K, Aizawa T, Yamakado M, Nagai R, Ohno M (2008) Manganese superoxide dismutase polymorphism affects the oxidized low-density lipoprotein-induced apoptosis of macrophages and coronary artery disease. Eur Heart J 29:1267–1274PubMedCrossRefGoogle Scholar
- Novák M, Emmanuel S, Vile MA, Erel Y, Véron A, Paces T, Wieder RK, Vanecek M, Stepánová M, Brízová E, Hovorka J (2003) Origin of lead in eight Central European peat bogs determined from isotope ratios, strengths, and operation times of regional pollution sources. Environ Sci Technol 37:437–445PubMedCrossRefGoogle Scholar
- Rose GA, Blackburn H, Gillum RF, Prineas RJ (1982) Cardiovascular survey methods, 2nd edn. World Health Organization, GenevaGoogle Scholar
- Shimoda-Matsubayashi S, Matsumine H, Kobayashi T, Nakagawa-Hattori Y, Shimizu Y, Mizuno Y (1996) Structural dimorphism in the mitochondrial targeting sequence in the human manganese superoxide dismutase gene. A predictive evidence for conformational change to influence mitochondrial transport and a study of allelic association in Parkinson’s disease. Biochem Biophys Res Commun 226:561–565PubMedCrossRefGoogle Scholar
- World Health Organization (1981) Environmental health criteria 18: arsenic. World Health Organization, GenevaGoogle Scholar