Archives of Toxicology

, Volume 86, Issue 6, pp 869–878

Elevated risk of hypertension induced by arsenic exposure in Taiwanese rural residents: possible effects of manganese superoxide dismutase (MnSOD) and 8-oxoguanine DNA glycosylase (OGG1) genes

  • Shiuan-Chih Chen
  • Chun-Chieh Chen
  • Chung-Yih Kuo
  • Chun-Huang Huang
  • Chin-Hsiu Lin
  • Zi-Yun Lu
  • Yi-Yu Chen
  • Hong-Shen Lee
  • Ruey-Hong Wong
Inorganic Compounds

DOI: 10.1007/s00204-011-0797-8

Cite this article as:
Chen, SC., Chen, CC., Kuo, CY. et al. Arch Toxicol (2012) 86: 869. doi:10.1007/s00204-011-0797-8
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Abstract

Heavy metals, including arsenic and lead, may lead to cellular oxidative damage that is linked to hypertension. Manganese superoxide dismutase (MnSOD) is a scavenger of reactive oxygen species, and 8-oxoguanine DNA glycosylase (OGG1) is the major glycosylase that repairs DNA lesions. Interestingly, whether there is an elevated risk of hypertension with arsenic or lead exposure in individuals with genetic variations in MnSOD or OGG1 has not yet been investigated. Questionnaires were administered to 240 Taiwanese rural residents. Blood pressure and biochemical indicators were assessed in each subject. Urinary levels of arsenic and lead were measured with atomic absorption spectrometry; and MnSOD and OGG1 genotypes were identified via polymerase chain reaction. There was a dose–response relationship between urinary arsenic levels and risk of hypertension (P = 0.021, test for trend). However, there was no association between urinary lead levels and hypertension risk. Individuals with high urinary arsenic levels and the MnSOD ValAla/AlaAla genotypes had a greater risk of hypertension than those with low urinary arsenic levels and the MnSOD ValVal genotype (odds ratio [OR] = 4.2, 95% confidence interval [CI] = 1.7–10.3). Subjects with a high urinary arsenic level and the OGG1 CysCys genotype also had a greater risk of hypertension than those with a low urinary arsenic level and the OGG1 SerSer/SerCys genotypes (OR = 3.4, 95% CI = 1.1–10.7). Thus, both MnSOD and OGG1 genotypes may be prone to an increased risk of hypertension associated with arsenic exposure.

Keywords

Hypertension Arsenic Lead MnSOD gene OGG1 gene 

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Shiuan-Chih Chen
    • 1
    • 2
    • 3
  • Chun-Chieh Chen
    • 1
    • 2
    • 3
  • Chung-Yih Kuo
    • 4
  • Chun-Huang Huang
    • 5
  • Chin-Hsiu Lin
    • 4
  • Zi-Yun Lu
    • 4
  • Yi-Yu Chen
    • 4
  • Hong-Shen Lee
    • 4
  • Ruey-Hong Wong
    • 1
    • 2
    • 4
  1. 1.Department of Family and Community MedicineChung Shan Medical University HospitalTaichungTaiwan
  2. 2.Department of Occupational MedicineChung Shan Medical University HospitalTaichungTaiwan
  3. 3.School of MedicineChung Shan Medical UniversityTaichungTaiwan
  4. 4.Department of Public HealthChung Shan Medical UniversityTaichungTaiwan
  5. 5.Institute of MedicineChung Shan Medical UniversityTaichungTaiwan

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