Statistical evaluation of the in vivo micronucleus assay
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The statistical evaluation of the in vivo micronucleus assay is focused on multiple contrast tests for comparisons versus the negative control for count data taking the between-animals variability into account. For a possible claim the compound is not genotoxic in the micronucleus assay a proof of safety approach is proposed. For these statistical approaches user-friendly software is free available.
KeywordsIn vivo micronucleus assay Statistics Software
Parts of this work were supported by EC-JRC, ECVAM, project number CCR.IHCP.C433223.X0.
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