Archives of Toxicology

, 82:933

Munich Oktoberfest experience: remarkable impact of sex and age in ethanol intoxication

  • C. Binner
  • S. Selinski
  • M. J. Barysch
  • C. Pölcher
  • Wiebke Schormann
  • Matthias Hermes
  • Marc Brulport
  • Alexander Bauer
  • Claudia Rudolph
  • Essam Bedawy
  • Markus Schug
  • Klaus Golka
  • D. Hasenclever
  • H. Trauer
  • R. Lessig
  • H. M. Bolt
  • K. Ickstadt
  • Jan Georg Hengstler
Molecular Toxicology

Abstract

Approximately 5,000 of 6 million annual visitors of the Oktoberfest in Munich have to undergo medical treatment. Patients with alcohol intoxication without trauma or further complications are all treated in a specialized medical camp. We studied these patients in order to identify risk factors and to assess the relevance of the Glasgow Coma Score (GCS) and of ethanol blood concentrations for patient management. In 2004 totally 405 patients suffering from ethanol intoxication without trauma were treated in the medical camp. A complete set of the following data was obtained from all 405 patients: GCS, ethanol blood concentration, age, sex, blood pressure (mean, systolic and diastolic), body temperature, heart rate, blood sugar, GOT, γ-GT, and CK. A multivariate logistic regression model was applied to identify risk factors predicting patients at increased risk of hospitalization. Low GCS (≤8 vs. >8, OR: 4.18, CI: 1.96–8.65) low age (20–29 vs. ≥30 years, OR: 2.35, CI: 1.05–5.65) and male gender (male vs. female, OR: 3.58, CI: 1.36–9.34) independently predicted patients that had to be hospitalized. All other parameters including ethanol blood concentrations were not explanatory. Patients with GCS ≤ 8 (n = 66) had a lower median blood pressure (P = 0.0312) and showed a smaller increase in blood pressure during the observation period compared to patients with GCS > 8 (P < 0.001), suggesting that this subgroup may require longer recovery periods. Men aged 20–29 years were at highest risk for hospital admission. Increased risk could not be explained by higher ethanol blood concentrations in this subgroup. Importantly, GCS < 6 does not justify endotracheal intubation in ethanol intoxicated patients, when further complications, such as trauma, can be excluded.

Keywords

Ethanol intoxication Glasgow coma score Hospitalization Endotracheal intubation Acute alcohol intoxication 

Supplementary material

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(DOCX 24 kb)
204_2008_373_MOESM2_ESM.ppt (216 kb)
(PPT 231 kb)

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • C. Binner
    • 1
  • S. Selinski
    • 3
  • M. J. Barysch
    • 2
  • C. Pölcher
    • 4
  • Wiebke Schormann
    • 5
  • Matthias Hermes
    • 5
  • Marc Brulport
    • 5
  • Alexander Bauer
    • 5
  • Claudia Rudolph
    • 5
  • Essam Bedawy
    • 5
  • Markus Schug
    • 5
  • Klaus Golka
    • 5
  • D. Hasenclever
    • 6
  • H. Trauer
    • 2
  • R. Lessig
    • 2
  • H. M. Bolt
    • 5
  • K. Ickstadt
    • 3
  • Jan Georg Hengstler
    • 5
  1. 1.Division of Thoracic and Cardiovascular SurgeryHeart Center Leipzig of the University of LeipzigLeipzigGermany
  2. 2.Center of Toxicology, Institute of Legal Medicine and Rudolf Boehm InstituteUniversity of LeipzigLeipzigGermany
  3. 3.Department of Statistics, Collaborative Research Center 475University of DortmundDortmundGermany
  4. 4.Department of AnaesthesiologyCharité, University Hospital BerlinBerlinGermany
  5. 5.Leibniz Research Centre for Working Environment and Human Factors (IfADo)University of DortmundDortmundGermany
  6. 6.Institute for Medical Informatics, Statistics and Epidemiology (IMISE)University of LeipzigLeipzigGermany

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