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Archives of Toxicology

, Volume 82, Issue 10, pp 667–715 | Cite as

Inhibition and induction of human cytochrome P450 enzymes: current status

  • Olavi Pelkonen
  • Miia Turpeinen
  • Jukka Hakkola
  • Paavo Honkakoski
  • Janne Hukkanen
  • Hannu Raunio
Review Article

Abstract

Variability of drug metabolism, especially that of the most important phase I enzymes or cytochrome P450 (CYP) enzymes, is an important complicating factor in many areas of pharmacology and toxicology, in drug development, preclinical toxicity studies, clinical trials, drug therapy, environmental exposures and risk assessment. These frequently enormous consequences in mind, predictive and pre-emptying measures have been a top priority in both pharmacology and toxicology. This means the development of predictive in vitro approaches. The sound prediction is always based on the firm background of basic research on the phenomena of inhibition and induction and their underlying mechanisms; consequently the description of these aspects is the purpose of this review. We cover both inhibition and induction of CYP enzymes, always keeping in mind the basic mechanisms on which to build predictive and preventive in vitro approaches. Just because validation is an essential part of any in vitro–in vivo extrapolation scenario, we cover also necessary in vivo research and findings in order to provide a proper view to justify in vitro approaches and observations.

Keywords

Cytochrome P450 (CYP) Inhibition Induction 

Notes

Acknowledgments

The authors wish to thank the following sources for support to their research: The Academy of Finland, the Finnish Funding Agency for Technological Research and Innovation (TEKES), The EU COST Programme (COST B15 and COST B25).

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Olavi Pelkonen
    • 1
  • Miia Turpeinen
    • 1
    • 2
    • 3
  • Jukka Hakkola
    • 1
  • Paavo Honkakoski
    • 4
  • Janne Hukkanen
    • 5
  • Hannu Raunio
    • 6
  1. 1.Department of Pharmacology and Toxicology, Institute of BiomedicineUniversity of OuluOuluFinland
  2. 2.Dr. Margarete Fischer-Bosch Institute of Clinical PharmacologyStuttgartGermany
  3. 3.Department of Clinical PharmacologyUniversity of TübingenTübingenGermany
  4. 4.Department of PharmaceuticsUniversity of KuopioKuopioFinland
  5. 5.Department of Internal MedicineOulu University HospitalOuluFinland
  6. 6.Department of Pharmacology and ToxicologyUniversity of KuopioKuopioFinland

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