Archives of Toxicology

, Volume 82, Issue 5, pp 273–299

Intracellular redox status and oxidative stress: implications for cell proliferation, apoptosis, and carcinogenesis

  • José M. Matés
  • Juan A. Segura
  • Francisco J. Alonso
  • Javier Márquez
Review Article

DOI: 10.1007/s00204-008-0304-z

Cite this article as:
Matés, J.M., Segura, J.A., Alonso, F.J. et al. Arch Toxicol (2008) 82: 273. doi:10.1007/s00204-008-0304-z

Abstract

Oxidative stress can be defined as the imbalance between cellular oxidant species production and antioxidant capability. Reactive oxygen species (ROS) are involved in a variety of different cellular processes ranging from apoptosis and necrosis to cell proliferation and carcinogenesis. In fact, molecular events, such as induction of cell proliferation, decreased apoptosis, and oxidative DNA damage have been proposed to be critically involved in carcinogenesis. Carcinogenicity and aging are characterized by a set of complex endpoints, which appear as a series of molecular reactions. ROS can modify many intracellular signaling pathways including protein phosphatases, protein kinases, and transcription factors, suggesting that the majority of the effects of ROS are through their actions on signaling pathways rather than via non-specific damage of macromolecules; however, exact mechanisms by which redox status induces cells to proliferate or to die, and how oxidative stress can lead to processes evoking tumor formation are still under investigation.

Keywords

Apoptosis Cancer Glutamine p53 Protein kinases ROS 

Abbreviations

AP-1

Activating protein-1

ASK1

Apoptosis signal-regulating kinase 1

CDK

Cyclin-dependent kinase

C/EBP

CAAT/enhancer-binding protein

COX-2

Cyclooxygenase-2

DDR

DNA damage response

DHMC

7,8-Dihydroxy-4-methylcoumarin

DISC

Death-inducing signaling complex

DMBA

7,12-Dimethylbenz[a]anthracene

ERK

Extracellular signal-regulated kinase

FAA

Flavone acetic acid

FADD

Fas-associated death domain protein

Fe-NTA

Ferric nitrilotriacetate

GA

Glutaminase

GABA

Gamma-aminobutyric acid

GSH

Glutathione

GSSG

Oxidized glutathione

GST

Glutathione S-transferase

GTP

Guanosine-5′-triphosphate

HSP

Heat shock protein

IGF

Insuline-like growth factor

IL

Interleukine

JNK

c-Jun NH2-terminal kinase

LPS

Lipopolysaccharide

MAPK

Mitogen-activated protein kinase

MDM

Murine double minute

MKP-1

MAPK phosphatase-1

MT

Metallothioneins

NAC

N-acetyl-l-cysteine

NADPH

Reduced nicotinamide-adenine dinucleotide phosphate

NFAT

Nuclear factor of activated T cells

NFκB

Necrosis factor kappa B

NO

Nitric oxide

NOS

Nitric oxide synthase

PARP

Poly(ADP-ribose) polymerase

PCNA

Proliferating cell nuclear antigen

PD

Parkinson’s disease

PI3-K

Phosphatidylinositol 3-kinase

PK

Protein kinase

POX

Proline oxidase

RNS

Reactive nitrogen species

ROK

Rho kinase

ROS

Reactive oxygen species

SOD

Superoxide dismutase

TAK-1

Transforming growth factor-beta-activated kinase-1

TGF

Transforming growth factor

TNF

Tumor necrosis factor

TRAIL

Tumor necrosis factor-alpha-related apoptosis-inducing ligand

UCP2

Uncoupling protein-2

8-OHdG

8-Hydroxy-2′-deoxyguanosine

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • José M. Matés
    • 1
  • Juan A. Segura
    • 1
  • Francisco J. Alonso
    • 1
  • Javier Márquez
    • 1
  1. 1.Department of Biología Molecular y Bioquímica, Facultad de Ciencias, Campus de TeatinosUniversidad de MálagaMálagaSpain

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