Archives of Toxicology

, Volume 81, Issue 10, pp 675–681 | Cite as

Renal deterioration caused by carcinogens as a consequence of free radical mediated tissue damage: a review of the protective action of melatonin

  • Fatih GultekinEmail author
  • Hicran Hicyilmaz
Review Article


This brief review summarizes some of the publications that document the preventive role of melatonin in kidney damage caused by carcinogens such as 2-nitropropane, arsenic, carbon tetrachloride, nitrilotriacetic acid and potassium bromate. Numerous chemicals generate excessive free radicals that eventually induce renal worsening. Melatonin partially or totally prevents free radical mediated tissue damages induced by many carcinogens. Protective actions of melatonin against the harmful effects of carcinogens are believed to stem from its direct free radical scavenging and indirect antioxidant activities. Dietary or pharmacologically given melatonin may attenuate the oxidative stress, thereby mitigating the subsequent renal damage.


Melatonin Kidney Free radical 2-Nitropropane Arsenic Carbon tetrachloride Nitrilotriacetic acid Potassium bromate 


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  1. 1.School of Medicine, Department of BiochemistrySuleyman Demirel UniversityIspartaTurkey

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