Archives of Toxicology

, Volume 77, Issue 10, pp 591–593

Acetaldehyde adducts in the brain of alcoholics

  • Kazuhiko Nakamura
  • Kazuhiko Iwahashi
  • Aizo Furukawa
  • Kiyoshi Ameno
  • Hiroshi Kinoshita
  • Iwao Ijiri
  • Yoshimoto Sekine
  • Katsuaki Suzuki
  • Yasuhide Iwata
  • Yoshio Minabe
  • Norio Mori
Genotoxicity

Abstract

Acetaldehyde binds to some proteins and becomes a Schiff base. It is assumed that after the consumption of ethanol the acetaldehyde binds to the proteins to form adducts, and such acetaldehyde adducts are associated with organ diseases. We investigated the detection of acetaldehyde adducts in the brain region of a human alcoholics. Brain samples collected from an alcoholic autopsied case were used. Determination of acetaldehyde adducts was performed using a fluorescence immmunohistochemical staining method with antibodies against acetaldehyde adducts. We demonstrated acetaldehyde adducts in the frontal cortex and the midbrain of an alcoholics. Our studies showed that an acetaldehyde adduct was produced in the brain of alcoholics.

Keywords

Acetaldehyde adduct Alcoholics Brain 

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Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • Kazuhiko Nakamura
    • 1
  • Kazuhiko Iwahashi
    • 2
  • Aizo Furukawa
    • 3
  • Kiyoshi Ameno
    • 4
  • Hiroshi Kinoshita
    • 4
  • Iwao Ijiri
    • 4
  • Yoshimoto Sekine
    • 1
  • Katsuaki Suzuki
    • 1
  • Yasuhide Iwata
    • 1
  • Yoshio Minabe
    • 1
  • Norio Mori
    • 1
  1. 1.Department of Psychiatry and NeurologyHamamatsu University School of MedicineShizuokaJapan
  2. 2.Health Administration CenterAzabu UniversityKanagawaJapan
  3. 3.Department of Biochemistry, Faculty of MedicineKagawa Medical UniversityKagawaJapan
  4. 4.Department of Forensic, Faculty of MedicineKagawa Medical UniversityKagawaJapan

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