Osteoporosis International

, Volume 13, Issue 4, pp 278–287

Processing and Analysis of In Vivo High-Resolution MR Images of Trabecular Bone for Longitudinal Studies: Reproducibility of Structural Measures and Micro-Finite Element Analysis Derived Mechanical Properties

  • D. C. Newitt
  • B. van Rietbergen
  • S. Majumdar
Original Article

DOI: 10.1007/s001980200027

Cite this article as:
Newitt, D., van Rietbergen, B. & Majumdar, S. Osteoporos Int (2002) 13: 278. doi:10.1007/s001980200027

Abstract:

The authors have developed a system for the characterization of trabecular bone structure from high-resolution MR images. It features largely automated coil inhomogeneity correction, trabecular bone region segmentation, serial image registration, bone/marrow binarization, and structural calculation steps. The system addresses problems of efficiency and inter- and intra-operator variability inherent in previous analyses. The system is evaluated on repetitive scans of 8 volunteers for both two-dimensional (2D) apparent structure calculations and three-dimensional (3D) mechanical calculations using micro-finite element analysis. Coil correction methods based on a priori knowledge of the coil sensitivity and on low-pass filtering of the high-resolution mages are compared and found to perform similarly. Image alignment is found to cause small but significant changes in some structural parameters. Overall the automated system provides on the order of a 3-fold decrease in trained operator time over previous manual methods. Reproducibility is found to be dependent on image quality for most parameters. For 7 subjects with good image quality, reproducibility of 2–4% is found for 2D structural parameters, while 3D mechanical parameters vary by 4–9%, with percent standardized coefficients of variation in the ranges of 15–34% and 20–38% respectively.

Key words:Finite element analysis – High-resolution – MRI – Osteoporosis – Trabecular bone 

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2002

Authors and Affiliations

  • D. C. Newitt
    • 1
  • B. van Rietbergen
    • 2
  • S. Majumdar
    • 1
  1. 1.MRSC, Department of Radiology, University of California, San Francisco, CA, USA;US
  2. 2.University of Eindhoven, Eindhoven, The NetherlandsNL

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