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Osteoporosis International

, Volume 11, Issue 7, pp 583–591 | Cite as

Polymorphisms of the VDR, ER and COLIA1 Genes and Osteoporotic Hip Fracture in Elderly Postmenopausal Women

  • J. Aerssens
  • J. Dequeker
  • J. Peeters
  • S. Breemans
  • P. Broos
  • S. Boonen
Original Article

Abstract:

In view of the reported associations between osteoporosis and polymorphisms of the vitamin D receptor (VDR), collagen Iα1 (COLIA1) and estrogen receptor (ER) genes, an association study was performed between VDR, COLIA1, and ER genotypes and bone mineral density, biochemical markers of bone turnover and hip fracture occurrence in Belgian older postmenopausal women. The gene polymorphisms were evaluated by restriction fragment length polymorphism analyses, using the restriction enzymes BsmI (VDR), AccB7I (COLIA1), and PvuII and XbaI (ER), respectively. As expected, bone mineral density and biochemical analyses demonstrated significant differences between hip fracture patients and elderly controls. However, no significant differences in genotype distributions or allele frequencies were observed between the cases (n= 135, age 78 ± 9 years) and controls (n= 239, age 76 ± 4 years) for any of the gene polymorphisms. Stratification of both study populations according to VDR, COLIA1 or ER genotype did not reveal any statistically significant difference in bone density or bone turnover between subgroups with different genotypes. In conclusion, despite its limited statistical power the outcome of this study does not support the hypothesis of a major contribution of the VDR, COLIA1 or ER polymorphisms to explain variations in bone mineral density or bone turnover, or to identify elderly women at risk of osteoporotic hip fracture.

Key words:COLIA1 polymorphism –ER polymorphism – Hip fracture –VDR polymorphism 

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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2000

Authors and Affiliations

  • J. Aerssens
    • 1
  • J. Dequeker
    • 1
  • J. Peeters
    • 1
  • S. Breemans
    • 1
  • P. Broos
    • 2
  • S. Boonen
    • 1
  1. 1.Arthritis and Metabolic Bone Disease Research UnitBE
  2. 2.Department of Surgery, Division of Traumatology and Emergency Surgery, K.U. Leuven, Leuven, BelgiumBE

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