Effects of anti-osteoporosis medications on radiological and clinical results after acute osteoporotic spinal fractures: a retrospective analysis of prospectively designed study

  • H.-K. Min
  • J.-H. Ahn
  • K.-Y. Ha
  • Y.-H. KimEmail author
  • S.-I. Kim
  • H.-Y. Park
  • K.-W. Rhyu
  • Y.-Y. Kim
  • I.-S. Oh
  • J.-Y. Seo
  • D.-G. Chang
  • J.-H. Cho
Original Article



Effects of anti-osteoporosis medications such as anti-resorptive and anabolic agents on healing of osteoporotic spinal fracture were retrospectively investigated. The use of anabolic agent significantly enhanced fracture healing, reduced progressive collapse, and presented good pain relief. These findings suggest that proper selection of medication could improve initial management of acute osteoporotic spinal fractures (OSFs).


Although anti-osteoporosis medications have beneficial effects on prevention of osteoporotic spinal fractures (OSFs), few studies have compared effects of medications on fracture healing following OSFs. Therefore, the purpose of this study was to elucidate the effects of different anti-osteoporosis medications on radiological and clinical outcomes after acute OSFs.


A total of 132 patients diagnosed with acute OSFs were enrolled and allocated into three groups [group I (n = 39, no anti-osteoporosis medication), group II (n = 66, bisphosphonate), and group III (n = 27, parathyroid hormone (PTH)]. Radiological parameters including magnetic resonance (MR) classification, occurrence of intravertebral cleft (IVC), and clinical outcomes such as numerical rating scale (NRS) and Oswestry disability index were assessed. Risk analyses for IVC and progressive collapse were done along the related factors and medication type.


IVC sign was observed in 30 patients. The rate of IVC sign was lower in group III (7.4%) than that in group I (20.5%) or group II (30.3%), although the difference was not statistically significant. Moreover, the degree of NRS improvement was better in group III than that in group I or group II (5.7 vs. 3.1 vs. 3.5, p < 0.001). On multiple regression analysis, mid-portion type fracture in MR classification was a significant risk factor for progressive OSFs. The use of PTH showed significant lower incidences of occurrence of IVC (odds ratio (OR) = 0.160) and increase in height loss (OR = 0.325).


Different anti-osteoporosis medications presented different clinical and radiological results after acute OSFs. The use of anabolic agent significantly enhanced fracture healing, reduced progressive collapse, and presented better clinical outcomes. Proper selection of medication might improve initial management of acute OSFs.


Bisphosphonates Nonunion Osteoporosis Osteoporotic spinal fractures Teriparatide 



This study was partially supported by investigator initiated trial funded by Dong-A Pharmaceuticals.

Compliance with ethical standards

Conflicts of interest


Ethical issues

This study was performed through retrospective analysis of clinical and radiological data. Approval of institutional review board was obtained before this submission.


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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2019

Authors and Affiliations

  1. 1.Department of Orthopedic Surgery, Seoul St. Mary’s Hospital, College of MedicineThe Catholic University of KoreaSeoulSouth Korea
  2. 2.Department of Orthopedic SurgeryMediplex Sejong HospitalIncheonSouth Korea
  3. 3.Department of Orthopedic Surgery, St. Vincent Hospital, College of MedicineThe Catholic University of KoreaSuwonSouth Korea
  4. 4.Department of Orthopedic Surgery, Daejeon St. Mary’s Hospital, College of MedicineThe Catholic University of KoreaDaejeonSouth Korea
  5. 5.Department of Orthopedic Surgery, Incheon St. Mary’s Hospital, College of MedicineThe Catholic University of KoreaIncheonSouth Korea
  6. 6.Department of Orthopedic Surgery, Jeju National University Hospital, School of MedicineJeju National UniversityJejuSouth Korea
  7. 7.Department of Orthopedic Surgery, Sanggye Paik Hospital, College of MedicineThe Inje UniversitySeoulSouth Korea

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