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Osteoporosis International

, Volume 30, Issue 1, pp 201–209 | Cite as

Trabecular microstructure is influenced by race and sex in Black and White young adults

  • K.L. PoppEmail author
  • C. Xu
  • A. Yuan
  • J.M. Hughes
  • G. Unnikrishnan
  • J. Reifman
  • M.L. Bouxsein
Original Article

Abstract

Summary

Lower fracture rates in Black men and women compared to their White counterparts are incompletely understood. High-resolution imaging specific to trabecular bone may provide insight. Black participants have enhanced trabecular morphology. These differences may contribute to the lower fracture risk in Black versus White individuals.

Introduction

Lower fracture rates in Black men and women compared to their White counterparts may be explained by favorable bone microstructure in Black individuals. Individual trabecular segmentation (ITS) analysis, which characterizes the alignment and plate- and rod-like nature of trabecular bone using high-resolution peripheral quantitative computed tomography (HR-pQCT), may provide insight into trabecular differences by race/ethnic origin.

Purpose

We determined differences in trabecular bone microarchitecture, connectivity, and alignment according to race/ethnic origin and sex in young adults.

Methods

We analyzed HR-pQCT scans of 184 adult (24.2 ± 3.4 years) women (n = 51 Black, n = 50 White) and men (n = 34 Black, n = 49 White). We used ANCOVA to compare bone outcomes, and adjusted for age, height, and weight.

Results

Overall, the effect of race on bone outcomes did not differ by sex, and the effect of sex on bone outcomes did not differ by race. After adjusting for covariates, Black participants and men of both races had greater trabecular plate volume fraction, plate thickness, plate number density, plate surface area, and greater axial alignment of trabeculae, leading to higher trabecular bone stiffness compared to White participants and women, respectively (p < 0.05 for all).

Conclusion

These findings demonstrate that more favorable bone microarchitecture in Black individuals compared to White individuals and in men compared to women is not unique to the cortical bone compartment. Enhanced plate-like morphology and greater trabecular axial alignment, established in young adulthood, may contribute to the improved bone strength and lower fracture risk in Black versus White individuals and in men compared to women.

Keywords

Bone mineral density (BMD) Fracture risk Gender High-resolution peripheral quantitative computed tomography (HR-pQCT) Individual trabecular segmentation Stress fracture risk 

Notes

Funding

This study is supported by the U.S. Department of Defense, Defense Health Program, and Joint Program Committee (W811XWH-15-C-0024) managed by the U.S. Army Military Operational Medicine Program at the U.S. Army Medical Research and Materiel Command, Fort Detrick, MD, and the National Institutes of Health shared instrumentation grant (S10 RR023405).

Compliance with ethical standards

Conflicts of interest

None.

Disclaimer

The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or reflecting the views of the U.S. Army or the U.S. Department of Defense. Any citations of commercial organizations and trade names in this report do not constitute an official Department of the Army endorsement of approval of the products or services of these organizations.

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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2018

Authors and Affiliations

  1. 1.Endocrine UnitMassachusetts General HospitalBostonUSA
  2. 2.Department of MedicineHarvard Medical SchoolBostonUSA
  3. 3.Military Performance DivisionUnited States Army Research Institute of Environmental MedicineNatickUSA
  4. 4.Department of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advance Technology Research CenterUnited States Army Medical Research and Materiel CommandFort DetrickUSA
  5. 5.Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, and Department of Orthopedic SurgeryHarvard Medical SchoolBostonUSA

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