Associations between radius low-frequency axial ultrasound velocity and bone fragility in elderly men and women
An exploratory study in elderly women and men from the Geneva Retirees Cohort indicates that low-frequency quantitative ultrasound measurement at the radius captures aBMD, bone size, and cortical tissue mineral density and might be used for screening purposes prior to DXA to evaluate fracture risk.
The contribution of distal radius bone mineral density (BMD) and cortical microstructure to fracture risk has recently been demonstrated. In this exploratory study, we investigated whether low-frequency quantitative ultrasound measurement at the distal radius may capture the peripheral determinants of bone fragility assessed with dual-energy X-ray absorptiometry (DXA) and high-resolution peripheral quantitative computed tomography (HR-pQCT).
Low-frequency velocity (VLF) was measured at the radius using OsCare Sono®, a portable axial transmission ultrasonometer, in 271 community-dwelling postmenopausal women and men (age 71.5 ± 1.4 years) from the Geneva Retirees Cohort. Cortical (Ct) and trabecular (Tb) volumetric (v) BMD and microstructure at the distal radius were assessed by HR-pQCT, in addition to areal (a) BMD by DXA, at the same time point.
VLF was highly correlated with aBMD at the distal third radius (r = 0.72, p < 0.001). For microstructure parameters, the highest correlation was observed with cortical area (r = 0.59, p < 0.001). VLF also captured bone geometry (total area) and cortical tissue mineral density independently of aBMD. In models adjusted for age and sex, VLF was significantly associated with prevalent low-trauma fractures [OR 95%CI for one SD decrease of VLF 1.50 (1.05, 2.14), p = 0.024], with discrimination performance comparable to femoral neck or distal radius aBMD.
Measurement of VLF at the radius captures aBMD, bone size, and cortical tissue mineral density and might be used for screening purposes prior to DXA to evaluate fracture risk.
KeywordsBone microstructure Bone mineral density Fracture Osteoporosis Ultrasonic low-frequency velocity
We are indebted to F. Merminod, A. Sigaud, and M. Hars for the management of participants, C. Genet and G. Conicella to for DXA and HR-pQCT measurements. We thank Dr. R. Zebaze and Pr E. Seeman for cortical porosity quantification with StrAx1.0 software. We thank the Swiss Foundation for Research on Ageing AETAS for the kind supply of its mobile osteodensitometer, the Geneva University Hospitals and Faculty of Medicine Clinical Research Center, the HUG Private Foundation, and Oscare Medical for their support. None of the funders had any influence on the study design, implementation, and analysis, and on interpretation of the data.
Compliance with ethical standards
The study protocol received approval from the Geneva University Hospitals’ Ethics Committee, and all participants provided written informed consent.
Conflicts of interest
Dr. E. Biver and Pr S. Ferrari report a research grant from Oscare Medical for a research project; Dr. Pepe, Dr. de Sire, and Pr Chevalley declare that they have no conflicts of interest.
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