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Osteoporosis International

, Volume 30, Issue 2, pp 375–381 | Cite as

Effect of acute downhill running on bone markers in responders and non-responders

  • S. A. Alkahtani
  • S. M. Yakout
  • J.-Y. Reginster
  • N. M. Al-DaghriEmail author
Original Article

Abstract

Summary

This study showed that procollagen type 1 amino-terminal pro-peptide and N-MID osteocalcin significantly increased after exercise independent of the form of muscle contraction. Thus, these preliminary results will be useful for future studies that will consider bone turnover characteristics of responders and non-responders to acute and chronic aerobic exercise.

Introduction

The aim of the current study was to compare the effects of acute flat running (FR) and downhill running (DHR) on bone turnover markers in men.

Methods

Fourteen healthy young active men performed three exercise tests in a counterbalanced order, including rest condition, FR, and DHR, at 60% maximal aerobic capacity on a treadmill with 0 and − 12% inclines. Blood samples were taken in the pre-exercise, immediately post-exercise, and 24-h post-exercise periods, and bone markers included total procollagen type 1 amino-terminal pro-peptide (total PINP) and N-MID osteocalcin.

Results

Total P1NP significantly increased after exercise independent of the form of muscle contraction (p > 0.05). N-MID osteocalcin increased after DHR by 17% compared to after pre-exercise, but the difference did not reach significance (p = 0.07; partial eta square, 0.21). Biomarker responses to exercise were dependent on the exercise form and independent of hormone type in half of the participants who were classified as responders. Physiological parameters and changes in muscle voluntary contraction did not explain the differences between responders and non-responders.

Conclusion

The effect of acute DHR on bone turnover is determined by biomarker type and participant characteristics. Future studies should discriminate between the characteristics of responders and those of non-responders.

Keywords

Bone markers Downhill running Eccentric exercise Responders 

Notes

Acknowledgments

The authors thank all participants, the Cardiovascular Laboratory, and all research assistants, particularly Mr. Abdullah Al-Qawati and Mr. Thabit Al-Aizari. Blood samples were collected by Mr. Abdul Aziz Alsahali from the Department of Clinical Laboratory Sciences at College of Applied Medical Sciences at KSU. The statistical analysis was performed by Mr. Malak Nawaz Khan Khattak from the Prince Mutaib bin Abdullah Chair for Biomarkers Research on Osteoporosis. The authors also thank Prof. Mark Willems from the University of Chichester for providing a DHR consultation.

Contributions

SA, SY, and NA designed the study; SA supervised the data collection process; and SY supervised the blood analysis. SA wrote the first draft of manuscript, SY and NA carefully revised some sections. JR intellectually contributed to the final version of the paper. All authors approved the final draft for publication submission.

Funding information

This research project was supported by a grant from the Research Centre for the Sports Science and Physical Activity, Deanship of Scientific Research at KSU.

Compliance with ethical standards

Conflicts of interest

None.

Ethical approval

The study was approved by the KSU Institutional Review Board (IRB No. E-16-1831).

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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2018

Authors and Affiliations

  1. 1.Department of Exercise Physiology, College of Sport Sciences and Physical ActivityKing Saud UniversityRiyadhSaudi Arabia
  2. 2.Prince Mutaib bin Abdullah Chair for Biomarkers Research on Osteoporosis, Department of Biochemistry, College of ScienceKing Saud UniversityRiyadhSaudi Arabia
  3. 3.Department of Public Health, Epidemiology and Health EconomicsUniversity of LiègeLiègeBelgium

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