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Osteoporosis International

, Volume 29, Issue 7, pp 1671–1674 | Cite as

Systemic mastocytosis identified in two women developing fragility fractures during lactation

  • J. J. Zhu
  • D. Mahendran
  • M. H. Lee
  • J. Seah
  • S. Fourlanos
  • S. Varadarajan
  • A. Ghasem-Zadeh
  • R. J. MacIsaac
  • E. Seeman
Case Report

Abstract

Two women presenting with fragility fractures during lactation had bone mineral density (BMD) reduced more greatly than usually associated with lactation. The first woman was 29 years old with a BMD T-score of − 3.2 SD at the spine and− 2.0 SD at the femoral neck. The second woman was 35 years old with a BMD T-score of − 4.5 SD at the spine and − 2.8 SD at the femoral neck. Both women had increased cortical porosity and reduced trabecular density. Investigation identified an elevated serum tryptase, and marrow biopsy confirmed the diagnosis of mastocytosis. Lactation causes bone loss, but the occurrence of fractures in the setting of severe deficits in BMD and microstructural deterioration signals the need to consider additional causes of bone loss.

Keywords

Bone loss Fractures Lactation Mastocytosis Osteoporosis 

Notes

Compliance with ethical standards

Conflicts of interest

None.

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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2018

Authors and Affiliations

  • J. J. Zhu
    • 1
  • D. Mahendran
    • 2
    • 3
  • M. H. Lee
    • 1
  • J. Seah
    • 2
  • S. Fourlanos
    • 3
    • 4
  • S. Varadarajan
    • 3
  • A. Ghasem-Zadeh
    • 2
  • R. J. MacIsaac
    • 1
    • 5
  • E. Seeman
    • 2
    • 5
    • 6
  1. 1.Department of Endocrinology & DiabetesSt Vincent’s Hospital MelbourneFitzroyAustralia
  2. 2.Endocrine Centre of Excellence, Austin HealthHeidelbergAustralia
  3. 3.Department of Endocrinology & DiabetesThe Northern HospitalEppingAustralia
  4. 4.Department of Endocrinology & DiabetesRoyal Melbourne HospitalParkvilleAustralia
  5. 5.Department of MedicineThe University of MelbourneParkvilleAustralia
  6. 6.Mary MacKillop Institute for Health ResearchAustralian Catholic UniversityMelbourneAustralia

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