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Osteoporosis International

, Volume 29, Issue 7, pp 1683–1683 | Cite as

Reduced bone mineral density in human immunodeficiency virus-infected individuals: a meta-analysis of its prevalence and risk factors: supplementary presentation

  • S. S. L. Goh
  • P. S. M. Lai
  • A. T. B. Tan
  • S. Ponnampalavanar
Supplementary Presentation
  • 339 Downloads

Abstract

A meta-analysis was conducted to evaluate the prevalence of osteopenia/osteoporosis in human immunodeficiency virus (HIV)-infected individuals. The prevalence of osteopenia/osteoporosis in HIV-infected and antiretroviral therapy (ART)-treated individuals was significantly higher than respective controls. Evidence regarding bone loss within first year of HIV infection or ART initiation was preliminary.

Keywords

Antiretroviral therapy Bone density HIV Osteopenia Osteoporosis 

Key scientific question

The scientific question addressed in the present paper was to systematically review published literature on the prevalence of osteopenia/osteoporosis and its associated risk factors in HIV-infected individuals [1].

Key findings

The prevalence of osteopenia/osteoporosis in HIV-infected and ART-treated individuals was significantly higher than respective controls. However, evidence regarding bone loss within first year of HIV infection or ART initiation was preliminary.

Importance, timeliness, and interest

Bone loss in HIV-infected individuals may be more acute and accelerated, while in older people, bone loss occurs gradually over time. We recommend that HIV-infected and ART-treated individuals should be screened for osteopenia/osteoporosis during the first year of HIV infection or ART initiation, regardless of age or gender.

Significance of findings

The prevalence of osteopenia/osteoporosis in HIV-infected and ART-treated individuals was two times more compared to controls. However, evidence concerning bone loss within the first year of HIV infection and ART initiation was preliminary. Findings from this study may assist clinicians to decide on when to screen HIV-infected individuals for osteopenia/osteoporosis as it is important to prevent unwanted fractures and to treat them accordingly.

Notes

Compliance with ethical standards

Conflict of interest

None.

Supplementary material

198_2018_4379_MOESM1_ESM.mp4 (42.7 mb)
ESM 1 (MP4 43,685 kb)
198_2018_4379_MOESM2_ESM.pdf (801 kb)
ESM 2 (PDF 800 kb)

Reference

  1. 1.
    Goh SSL et al (2017) Reduced bone mineral density in human immunodeficiency virus-infected individuals: a meta-analysis of its prevalence and risk factors. Osteoporos IntGoogle Scholar

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2018

Authors and Affiliations

  • S. S. L. Goh
    • 1
  • P. S. M. Lai
    • 1
  • A. T. B. Tan
    • 2
  • S. Ponnampalavanar
    • 3
  1. 1.Department of Primary Care Medicine, University of Malaya Primary Care Research Group, Faculty of MedicineUniversity of MalayaKuala LumpurMalaysia
  2. 2.Department of Medicine (Endocrine), Faculty of MedicineUniversity of MalayaKuala LumpurMalaysia
  3. 3.Department of Medicine (Infectious Disease), Faculty of MedicineUniversity of MalayaKuala LumpurMalaysia

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