Osteoporosis International

, Volume 28, Issue 10, pp 2945–2953 | Cite as

Short-term effects of extracorporeal shock wave therapy on bone mineral density in postmenopausal osteoporotic patients

  • L. Shi
  • F. Gao
  • W. Sun
  • B. Wang
  • W. Guo
  • L. Cheng
  • Z. Li
  • W. Wang
Original Article



It has been proved that extracorporeal shock wave therapy (ESWT) could promote new bone formation. Therefore, we designed an experiment to test the efficiency of ESWT on BMD in postmenopausal osteoporotic patients. The results showed that ESWT could effectively improve the local bone mass of the treated bone area within a short duration.


This study evaluated the short-term effectiveness of extracorporeal shock wave therapy (ESWT) on bone mineral density (BMD).


A total of 64 postmenopausal osteoporotic patients were recruited and randomized into 3 groups in 2015. Groups A (n = 20) and B (n = 21) patients received a single-session of low- or high-energy flux density (EFD) ESWT in the left hip, respectively, whereas group C (n = 23) patients served as controls without the ESWT treatment. All patients self-administered alendronate sodium tablets orally for a year. The BMD of the lumbar spine (L2-L4), femoral neck, great tuberosity, and total left hip was measured before ESWT treatment and at 3, 6, and 12 months using dual energy X-ray absorptiometry (DEXA).


At 12 months, the lumbar spine, femoral neck, great tuberosity, and total left hip BMD in all patients had increased (p < 0.01). The increase in lumbar spine BMD in group A patients was higher than that in group B patients (p = 0.03); other between-group differences were not observed (p = 0.73, group A vs. C; p = 0.06, group B vs. C). The femoral neck, great tuberosity, and total left hip BMD increases in group B patients were higher than that in either group A or C (p < 0.01, group B vs. A; p < 0.01, group A vs. C).


This study showed that ESWT could efficiently improve the local BMD; relatively, the high dosage was effective.


Bone mineral density Extracorporeal shock wave therapy Osteoporosis Postmenopausal 



We would like to thank all the patients who participated in this study. We thank our colleagues and all the staff members involved in this trial for their enormous efforts in collecting and ensuring the accuracy and completeness of all the data.

Compliance with ethical standards

All patients provided written informed consent before participating in the prospective trial, and prior approval for this study was obtained from the Scientific Review Board of China-Japan Friendship Hospital.

Ethical approval

All procedures performed in this study involving human participants were in compliance with the Ethical Standards of the Institutional and/or National Research Committee and the 1964 Helsinki Declaration and its later amendments.


This study was supported by the Beijing Natural Science Foundation (7174346), the National Natural Science Foundation of China (81372013, 81672236), the Research Fund of China-Japan Friendship Hospital (2014-4-QN-29), and the China-Japan Friendship Hospital Youth Science and Technology Excellence Project (2014-QNYC-A-06).

Conflict of interest



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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2017

Authors and Affiliations

  • L. Shi
    • 1
  • F. Gao
    • 2
    • 3
  • W. Sun
    • 2
    • 3
  • B. Wang
    • 2
  • W. Guo
    • 2
  • L. Cheng
    • 2
  • Z. Li
    • 2
  • W. Wang
    • 2
  1. 1.Department of OrthopedicsPeking University China-Japan Friendship School of Clinical MedicineBeijingChina
  2. 2.Centre for Osteonecrosis and Joint-Preserving & Reconstruction, Department of Orthopedic Surgery, Beijing Key Laboratory of Arthritic and Rheumatic DiseasesChina-Japan Friendship Hospital, National Health and Family Planning Commission of the People’s Republic of ChinaBeijingChina
  3. 3.Department of Orthopedic SurgeryChina-Japan Friendship HospitalBeijingChina

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