Risk of fragility fracture among patients with sarcoidosis: a population-based study 1976–2013—supplementary presentation

Supplementary Presentation
  • 74 Downloads

Abstract

Incidence of fragility fracture of a population-based cohort of 345 patients with sarcoidosis was compared with age- and sex-matched comparators. The incidence of fragility fracture was higher among patients with sarcoidosis with a hazard ratio (HR) of 2.18.

Introduction

Several chronic inflammatory disorders increase the risk of fragility fracture. However, little is known about the risk of fragility fracture in patients with sarcoidosis.

Methods

This study was conducted using a previously identified population-based cohort of 345 patients with incident sarcoidosis from Olmsted County, Minnesota. Diagnosis of sarcoidosis required physician diagnosis supported by biopsy showing non-caseating granuloma, radiographic evidence of intrathoracic sarcoidosis, and compatible clinical presentations without evidence of other granulomatous diseases. Sex- and age-matched subjects randomly selected from the same underlying population were used as comparators. Medical records of cases and comparators were reviewed for baseline characteristics and incident fragility fracture.

Results

Fragility fractures were observed in 34 patients with sarcoidosis, corresponding to a cumulative incidence of 5.6% at 10 years, while 18 fragility fractures were observed among comparators for a cumulative incidence of 2.4% at 10 years. The HR of fragility fractures among cases compared with comparators was 2.18 (95% confidence interval [CI], 1.23–3.88). The risk of fragility fracture by site was significantly higher among patients with sarcoidosis and was due to a higher rate of distal forearm fracture (HR 3.58; 95% CI 1.53–8.40). Statistically non-significant increased risk was also observed in proximal femur (HR 1.66; 95% CI 0.45–6.06) and proximal humerus (HR 3.27; 95% CI 0.66–16.21). Risk of vertebral fracture was not increased (HR 1.00; 95% CI 0.32–3.11).

Conclusion

Patients with sarcoidosis have an increased risk of fragility fracture which is primarily driven by the higher incidence of distal forearm fracture [1].

Supplementary material

198_2017_4074_MOESM1_ESM.m4a (2.3 mb)
ESM 1 (M4A 2314 kb)
198_2017_4074_MOESM2_ESM.pptx (182 kb)
ESM 2 (PPTX 182 kb)

Reference

  1. 1.
    Ungprasert P, Crowson CS, Matteson EL (2017) Risk of fragility fracture among patients with sarcoidosis: a population-based study 1976–2013. Osteoporos Int 28:1875–1879.  https://doi.org/10.1007/s00198-017-3962-y CrossRefPubMedGoogle Scholar

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2018

Authors and Affiliations

  1. 1.Mayo ClinicRochesterUSA

Personalised recommendations