Osteoporosis International

, Volume 28, Issue 8, pp 2409–2419 | Cite as

Greater yogurt consumption is associated with increased bone mineral density and physical function in older adults

  • E. LairdEmail author
  • A. M. Molloy
  • H. McNulty
  • M. Ward
  • K. McCarroll
  • L. Hoey
  • C. F. Hughes
  • C. Cunningham
  • J. J. Strain
  • M. C. Casey
Original Article



In this cohort of community dwelling older adults (>60 years), we observed significant positive associations between the frequencies of yogurt intake with measures of bone density, bone biomarkers, and indicators of physical function. Improving yogurt intakes could be a valuable health strategy for maintaining bone health in older adults.


The associations of yogurt intakes with bone health and frailty in older adults are not well documented. The aim was to investigate the association of yogurt intakes with bone mineral density (BMD), bone biomarkers, and physical function in 4310 Irish adults from the Trinity, Ulster, Department of Agriculture aging cohort study (TUDA).


Bone measures included total hip, femoral neck, and vertebral BMD with bone biochemical markers. Physical function measures included Timed Up and Go (TUG), Instrumental Activities of Daily Living Scale, and Physical Self-Maintenance Scale.


Total hip and femoral neck BMD in females were 3.1–3.9% higher among those with the highest yogurt intakes (n = 970) compared to the lowest (n = 1109; P < 0.05) as were the TUG scores (−6.7%; P = 0.013). In males, tartrate-resistant acid phosphatase (TRAP 5b) concentrations were significantly lower in those with the highest yogurt intakes (−9.5%; P < 0.0001). In females, yogurt intake was a significant positive predictor of BMD at all regions. Each unit increase in yogurt intake in females was associated with a 31% lower risk of osteopenia (OR 0.69; 95% CI 0.49–0.96; P = 0.032) and a 39% lower risk of osteoporosis (OR 0.61; 95% CI 0.42–0.89; P = 0.012) and in males, a 52% lower risk of osteoporosis (OR 0.48; 95% CI 0.24–0.96; P = 0.038).


In this cohort, higher yogurt intake was associated with increased BMD and physical function scores. These results suggest that improving yogurt intakes could be a valuable public health strategy for maintaining bone health in older adults.


Aging BMD Frailty Physical function Yogurt 



The TUDA study was funded by the Irish Department of Agriculture, Food, and the Marine through the grants 07FHRIUCD1 (“JINGO” 2007–2013) and 13F407 (“JINGO–JPI”/“ENPADASI” 2014–2016) and from the Northern Ireland Department for Employment and Learning under its “Strengthening the all-Ireland Research Base” initiative. Funding for this study was also provided from The National Dairy Council Ireland. The funding organizations had no role in the design and conduct, collection, management, analysis, and interpretation of the data or in the preparation, review, or approval of this manuscript. The authors also acknowledge Drs Martin Healy, Adrian McCann, and Liadhan McAnena for bone biochemical analysis.

Compliance with ethical standards

Ethical approval was granted by the relevant authorities in each jurisdiction: the Research Ethics Committee of St. James’s Hospital and The Adelaide and Meath Hospital, Dublin, and the Office for Research Ethics Committees Northern Ireland (ORECNI; reference 08/NI/RO3113) with corresponding approvals from the Northern and Western Health and Social Care Trusts, Northern Ireland.

Conflict of interest


Supplementary material

198_2017_4049_MOESM1_ESM.docx (51 kb)
ESM 1 (DOCX 51 kb)


  1. 1.
    Cooper C (1999) Epidemiology of osteoporosis. Osteoporos Int 9(8):2–8CrossRefGoogle Scholar
  2. 2.
    Ström O, Borgström F, Kanis AJ, Compston J, Cooper C, McCloskey EV, Jönsson B (2011) Osteoporosis: burden, healthcare provision and opportunities in the EU. Arch Osteoporos 6(1):59–155PubMedCrossRefGoogle Scholar
  3. 3.
    Curtis JR, Blume SW (2011) Medical costs of osteoporosis in the elderly Medicare population. Osteoporos Int 22(6):1835–1844PubMedCrossRefGoogle Scholar
  4. 4.
    Holroyd C, Cooper C, Dennison E (2008) Epidemiology of osteoporosis. Best Pract Res Clin Endoc Meta 22(5):671–685CrossRefGoogle Scholar
  5. 5.
    Hernlund E, Svedbom A, Ivergård M, Compston J, Cooper C, Stenmark J, McCloskey EV, Jönsson B, Kanis JA (2013) Osteoporosis in the European Union: medical management, epidemiology and economic burden. Arch Osteoporos 8(1–2):1–15Google Scholar
  6. 6.
    Becker DJ, Kilgore ML, Morrisey MA (2010) The societal burden of osteoporosis. Curr Rheumatol Rep 2(3):186–191CrossRefGoogle Scholar
  7. 7.
    Mitchell BD, Yerges-Armstrong LM (2011) The genetics of bone loss: challenges and prospects. J Clin Endocrinol Metab 96(5):1258–1268PubMedPubMedCentralCrossRefGoogle Scholar
  8. 8.
    Greco EA, Fornari R, Rossi F et al (2010) Is obesity protective for osteoporosis? Evaluation of bone mineral density in individuals with high body mass index. Int J Clin Pract 64(6):817–820PubMedCrossRefGoogle Scholar
  9. 9.
    Rizzoli R (2008) Nutrition: its role in bone health. Best Pract Res Clin Endocrinol Metab 22(5):813–829PubMedCrossRefGoogle Scholar
  10. 10.
    Prentice AM (2014) Dairy products in global public health. Am J Clin Nutr 99(5):1212–1216CrossRefGoogle Scholar
  11. 11.
    Rice BH, Quann EE, Miller GD (2013) Meeting and exceeding dairy recommendations: effects of dairy consumption on nutrient intakes and risk of chronic disease. Nutr Rev 71(4):209–223PubMedPubMedCentralCrossRefGoogle Scholar
  12. 12.
    Heaney RP (2013) Dairy intake, dietary adequacy and lactose intolerance. Adv Nutr 4(2):151–156PubMedPubMedCentralCrossRefGoogle Scholar
  13. 13.
    Clarke M, Ward M, Strain JJ, Hoey L, Dickey W, McNulty H (2014) B-vitamins and bone in health and disease: the current evidence. Proc Nutr Soc 73(2):330–339PubMedCrossRefGoogle Scholar
  14. 14.
    Rizzoli R, Abraham C, Brandi ML (2014) Nutrition and bone health: turning knowledge and beliefs into healthy behaviour. Curr Med Res Opin 30(1):131–141PubMedCrossRefGoogle Scholar
  15. 15.
    Heaney RP (2009) Dairy and bone health. J Am Coll Nutr 28(Sup 1):82–90CrossRefGoogle Scholar
  16. 16.
    Dietary guidelines for Americans (2005) Dietary guidelines advisory committee report. 6. U.S. Department of Health and Human Services and U.S. Department of Agriculture, U.S. Government; WashingtonGoogle Scholar
  17. 17.
    Sahni S, Tucker KL, Kiel DP, Quach L, Casey VA, Hannan MT (2013) Milk and yogurt consumption are linked with higher bone mineral density but not with hip fracture: the Framingham Offspring Study. Arch Osteoporos 8(1–2):1–9Google Scholar
  18. 18.
    Laird E, McNulty H, Ward M et al (2014) Vitamin D deficiency is associated with inflammation in older Irish adults. J Clin Endocrinol Metab 99(5):1807–1815PubMedCrossRefGoogle Scholar
  19. 19.
    McCarroll K, Beirne A, Casey M et al (2015) Determinants of 25-hydroxyvitamin D in older Irish adults. Age Ageing 44(5):847–853PubMedCrossRefGoogle Scholar
  20. 20.
    Molloy AM, Pangilinan F, Mills JL et al (2016) A common polymorphism in HIBCH influences methylmalonic acid concentrations in blood independently of cobalamin. Am J Hum Genet 98(5):869–882PubMedPubMedCentralCrossRefGoogle Scholar
  21. 21.
    Laird E, Casey MC, Ward M et al (2016) Dairy intakes in older Irish adults and effects on vitamin micronutrient status: Data from the TUDA study. J Nutr Health Aging. In PressGoogle Scholar
  22. 22.
    Irish Universities Nutrition Alliance (2013) The Irish food portion sizes database (1st edition) 2013Google Scholar
  23. 23.
    World Health Organization (1992) Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: report of a WHO study group (meeting held in Rome from 22 to 25 June 1992)Google Scholar
  24. 24.
    Bischoff HA, Stähelin HB, Monsch AU et al (2003) Identifying a cut-off point for normal mobility: a comparison of the timed ‘up and go’ test in community-dwelling and institutionalised elderly women. Age Ageing 32(3):315–320PubMedCrossRefGoogle Scholar
  25. 25.
    Lawton MP, Brody EM (1969) Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist 9(3):179–186PubMedCrossRefGoogle Scholar
  26. 26.
    Hochberg MC, Greenspan S, Wasnich RD, Miller P, Thompson DE, Ross PD (2002) Changes in bone density and turnover explain the reductions in incidence of non-vertebral fractures that occur during treatment with anti-resorptive agents. J Clin Endocrinol Metab 87(4):1586–1592PubMedCrossRefGoogle Scholar
  27. 27.
    Henriksen K, Tanko LB, Qvist P, Delmas PD, Christiansen C, Karsdal MA (2007) Assessment of osteoclast number and function: application in the development of new and improved treatment modalities for bone diseases. Osteoporos Int 18(5):681–685PubMedCrossRefGoogle Scholar
  28. 28.
    Bonjour JP, Benoit V, Payen F, Kraenzlin M (2013) Consumption of yogurts fortified in vitamin D and calcium reduces serum parathyroid hormone and markers of bone resorption: a double-blind randomized controlled trial in institutionalized elderly women. J Clin Endocrinol Metab 98(7):2915–2921PubMedCrossRefGoogle Scholar
  29. 29.
    Schoene D, Wu SM, Mikolaizak AS, Menant JC, Smith ST, Delbaere K, Lord SR (2013) Discriminative ability and predictive validity of the timed up and go test in identifying older people who fall: systematic review and meta-analysis. J Am Geriatr Soc 61(2):202–208PubMedCrossRefGoogle Scholar
  30. 30.
    Lana A, Rodriguez-Artalejo F, Lopez-Garcia E (2015) Dairy consumption and risk of frailty in older adults: a prospective cohort study. J Am Geriatr Soc 63(9):1852–1860PubMedCrossRefGoogle Scholar
  31. 31.
    Radavelli-Bagatini S, Zhu K, Lewis JR, Dhaliwal SS, Prince RL (2013) Association of dairy intake with body composition and physical function in older community-dwelling women. J Acad Nutr Diet 113(12):1669–1674PubMedCrossRefGoogle Scholar
  32. 32.
    Matteini AM, Walston JD, Fallin MD et al (2008) Markers of B-vitamin deficiency and frailty in older women. J Nutr Health Aging 12(5):303–308PubMedPubMedCentralCrossRefGoogle Scholar
  33. 33.
    Shardell M, Hicks GE, Miller RR, Kritchevsky S, Andersen D, Bandinelli S, Cherubini A, Ferrucci L (2009) Association of low vitamin D levels with the frailty syndrome in men and women. J Gerontol A Biol Sci Med Sci 64(1):69–75PubMedCrossRefGoogle Scholar
  34. 34.
    Wang H, Livingston KA, Fox CS, Meigs JB, Jacques PF (2013) Yogurt consumption is associated with better diet quality and metabolic profile in American men and women. Nutr Res 33(1):18–26PubMedCrossRefGoogle Scholar
  35. 35.
    Mistura L, D’Addezio L, Sette S, Piccinelli R, Turrini A (2016) Diet quality of Italian yogurt consumers: an application of the probability of adequate nutrient intake score (PANDiet). Int J Food Sci Nutr 67(3):232–238PubMedCrossRefGoogle Scholar
  36. 36.
    Parvaneh K, Jamaluddin R, Karimi G, Erfani R (2014) Effect of probiotics supplementation on bone mineral content and bone mass density. ScientificWorldJournal 22:595962Google Scholar
  37. 37.
    Parvaneh K, Ebrahimi M, Sabran MR, Karimi G, Hwei AN, Abdul-Majeed S, Ahmad Z, Ibrahim Z, Jamaluddin R (2015) Probiotics (Bifidobacterium longum) increase bone mass density and upregulate Sparc and Bmp-2 genes in rats with bone loss resulting from ovariectomy. Biomed Res Int. doi: 10.1155/2015/897639 PubMedPubMedCentralGoogle Scholar
  38. 38.
    Korhonen H, Pihlanto A (2006) Bioactive peptides: production and functionality. Int Dairy J 16(9):945–960CrossRefGoogle Scholar
  39. 39.
    Rizzoli R, Bonjour JP (2004) Dietary protein and bone health. J Bone Miner Res 19(4):527–531PubMedCrossRefGoogle Scholar
  40. 40.
    Darling AL, Millward DJ, Torgerson DJ, Hewitt CE, Lanham-New SA (2009) Dietary protein and bone health: a systematic review and meta-analysis. Am J Clin Nutr 90(6):1674–1692PubMedCrossRefGoogle Scholar
  41. 41.
    Narva M, Collin M, Lamberg-Allardt C, Kärkkäinen M, Poussa T, Vapaatalo H, Korpela R (2004) Effects of long-term intervention with Lactobacillus helveticus-fermented milk on bone mineral density and bone mineral content in growing rats. Ann Nutr Metab 48(4):228–234PubMedCrossRefGoogle Scholar
  42. 42.
    Tu MY, Chen HL, Tung YT, Kao CC, Hu FC, Chen CM (2015) Short-term effects of kefir-fermented milk consumption on bone mineral density and bone metabolism in a randomized clinical trial of osteoporotic patients. PLoS One 10(12):e0144231PubMedPubMedCentralCrossRefGoogle Scholar
  43. 43.
    Gilbert JA, Bendsen NT, Tremblay A, Astrup A (2011) Effect of proteins from different sources on body composition. Nutr Metab Cardiovasc Dis 21:B16–B31PubMedCrossRefGoogle Scholar
  44. 44.
    Moreno LA, Bel-Serrat S, Santaliestra-Pasías A, Bueno G (2015) Dairy products, yogurt consumption, and cardiometabolic risk in children and adolescents. Nutr Rev 73(suppl 1):8–14PubMedCrossRefGoogle Scholar
  45. 45.
    Steves CJ, Bird S, Williams FM, Spector TD (2016) The microbiome and musculoskeletal conditions of aging: a review of evidence for impact and potential therapeutics. J Bone Miner Res 1 31(2):261–269CrossRefGoogle Scholar
  46. 46.
    Stanhope KL (2016) Sugar consumption, metabolic disease and obesity: the state of the controversy. Crit Rev Clin Lab Sci 53(1):52–67PubMedCrossRefGoogle Scholar
  47. 47.
    United States Department of Agriculture (USDA) (2016) National Nutrient Database for Standard Reference Release 8. Yogurt, fruit, low fat, 9 grams protein per 8 ounce, Basic Report 01120. Accessed 4th July 2016Google Scholar
  48. 48.
    United States Department of Agriculture (USDA) (2016) National Nutrient Database for Standard Reference Release 8. Yogurt, Greek, plain, low fat, Basic Report 01287. Accessed 4th July 2016Google Scholar
  49. 49.
    Rizzoli R (2014) Dairy products, yogurts, and bone health. Am J Clin Nutr 99(5):1256S–1262SPubMedCrossRefGoogle Scholar
  50. 50.
    Rozenberg S, Body JJ, Bruyère O et al (2016) Effects of dairy products consumption on health: benefits and beliefs—a commentary from the Belgian Bone Club and the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases. Calcif Tissue Int 98(1):1–7PubMedCrossRefGoogle Scholar
  51. 51.
    Teucher B, Dainty JR, Spinks CA et al (2008) Sodium and bone health: impact of moderately high and low salt intakes on calcium metabolism in postmenopausal women. J Bone Miner Res 23(9):1477–1485PubMedCrossRefGoogle Scholar
  52. 52.
    Bonjour JP, Benoit V, Rousseau B, Souberbielle JC (2012) Consumption of vitamin D-and calcium-fortified soft white cheese lowers the biochemical marker of bone resorption TRAP 5b in postmenopausal women at moderate risk of osteoporosis fracture. J Nutr 142(4):698–703PubMedCrossRefGoogle Scholar

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2017

Authors and Affiliations

  • E. Laird
    • 1
    Email author
  • A. M. Molloy
    • 1
  • H. McNulty
    • 2
  • M. Ward
    • 2
  • K. McCarroll
    • 3
  • L. Hoey
    • 2
  • C. F. Hughes
    • 2
  • C. Cunningham
    • 3
  • J. J. Strain
    • 2
  • M. C. Casey
    • 3
  1. 1.School of MedicineTrinity College DublinDublinIreland
  2. 2.Northern Ireland Centre for Food and HealthUlster University ColeraineUK
  3. 3.St James’s HospitalThe Mercers Institute for Research on AgeingDublinIreland

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