Bone mineral density among Korean females aged 20–50 years: influence of age at menarche (The Korea National Health and Nutrition Examination Survey 2008–2011)
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To evaluate a possible correlation between bone mineral density (BMD) and age at menarche, the present study used the BMD dataset of the Korea National Health and Nutrition Examination Survey IV-V (KNHANES IV-V). Age at menarche had a small but significant association with BMD of the lumbar spine in premenopausal Korean females, aged 20–50 years.
To investigate any correlation between bone mineral density (BMD) and age at menarche in Korean females using data from the fourth and fifth Korea National Health and Nutrition Examination Survey (KNHANES IV–V; 2008–2011).
In total, 37,753 individuals participated in health examination surveys between 2008 and 2011. A total of 5032 premenopausal females aged 20–50 years were eligible. Age, height, weight, and age at menarche were assessed.
Results from the univariate linear regression and analysis of covariance (ANCOVA) indicated that age (per 1 year), height (per 1 cm), weight (per 1 kg), exercise (per 1 day/week), familial osteoporosis history (yes), parity (n = 0 to ≥4), and menarche age distribution were associated with BMD of the total femur, femur neck, and lumbar spine. After stratifying the bone area and adjusting for age, parity, alcohol intake, smoking, exercise, and familial osteoporosis history, no effect was seen for the total femur or femur neck. Age at menarche 16~17 and ≥18 years groups were associated with BMD of the lumbar spine only.
Age at menarche had a small but significant association with BMD of the lumbar spine in premenopausal Korean females, aged 20–50 years. Females with late menarche may achieve lower peak bone mass at some skeletal sites, which may put them at greater risk for osteoporosis in later life.
KeywordsBone mineral density Menarche Osteoporosis
Korea National Health and Nutrition Examination Survey
Bone mineral density
Body mass index
This study was supported by Research Fund of Seoul St. Mary’s hospital, The Catholic University of Korea.
Compliance with ethical standards
Conflicts of interest
- 1.World Health Organization (2003) Prevention and management of osteoporosis. World Health Organ Tech Rep Ser 921:1–164Google Scholar
- 10.Korea National Health and Nutrition Examination Survey. Korea Center for Diasese Control and Prevention, 2014 (http://knhanes.cdc.go.kr)
- 12.Design and Methods: Quality control. Korea National Health and Nutrition Examination Survey, 2017 (https://knhanes.cdc.go.kr/knhanes/eng/index.do)