Osteoporosis International

, Volume 28, Issue 9, pp 2729–2730 | Cite as

Are more trials of calcium supplements really needed?



Compliance with ethical standards

Conflicts of interest

All authors have co-authored meta-analyses of calcium and vitamin D supplements and fracture. MB has nothing else to declare. AG is a shareholder in Auckland Bone Density, a company that provides bone mineral density measurements. IRR has research funding or consulting/speaking fees from Novartis, Merck, Amgen and Lilly.


The study was funded by the Health Research Council (HRC) of New Zealand.

The authors are independent of the HRC. The HRC had no role in design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.


  1. 1.
    Harvey NC, Biver E, Kaufman JM et al (2017) The role of calcium supplementation in healthy musculoskeletal ageing : an expert consensus meeting of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the International Foundation for Osteoporosis (IOF). Osteoporos Int 28:447–462CrossRefPubMedGoogle Scholar
  2. 2.
    Reid IR, Bolland MJ, Avenell A et al (2011) Cardiovascular effects of calcium supplementation. Osteoporos Int 22:1649–1658. doi: 10.1007/s00198-016-3773-6 CrossRefPubMedGoogle Scholar
  3. 3.
    Nordin BE, Lewis JR, Daly RM et al (2011) The calcium scare—what would Austin Bradford Hill have thought? Osteoporos Int 22:3073–3077CrossRefPubMedGoogle Scholar
  4. 4.
    Bolland MJ, Grey A, Reid IR (2011) Re: The calcium scare: what would Austin Bradford Hill have thought? Osteoporos Int 22:3079–3080CrossRefPubMedGoogle Scholar
  5. 5.
    Bolland MJ, Avenell A, Baron JA et al (2010) Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis. BMJ 341:c3691CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    Grant AM, Avenell A, Campbell MK et al (2005) Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised placebo-controlled trial. Lancet 365:1621–1628CrossRefGoogle Scholar
  7. 7.
    Jackson RD, LaCroix AZ, Gass M et al (2006) Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med 354:669–683CrossRefPubMedGoogle Scholar
  8. 8.
    Porthouse J, Cockayne S, King C et al (2005) Randomised controlled trial of calcium and supplementation with cholecalciferol (vitamin D3) for prevention of fractures in primary care. BMJ 330:1003CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Prince RL, Devine A, Dhaliwal SS et al (2006) Effects of calcium supplementation on clinical fracture and bone structure: results of a 5-year, double-blind, placebo-controlled trial in elderly women. Arch Intern Med 166:869–875CrossRefPubMedGoogle Scholar
  10. 10.
    Reid IR, Mason B, Horne A et al (2006) Randomized controlled trial of calcium in healthy older women. Am J Med 119:777–785CrossRefPubMedGoogle Scholar
  11. 11.
    Salovaara K, Tuppurainen M, Karkkainen M et al (2010) Effect of vitamin D(3) and calcium on fracture risk in 65- to 71-year-old women: a population-based 3-year randomized, controlled trial—the OSTPRE-FPS. J Bone Miner Res 25:1487–1495CrossRefPubMedGoogle Scholar
  12. 12.
    Bolland MJ, Leung W, Tai V et al (2015) Calcium intake and risk of fracture: systematic review. BMJ 351:h4580CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2017

Authors and Affiliations

  1. 1.Department of MedicineUniversity of AucklandAucklandNew Zealand
  2. 2.Bone and Joint Research Group, Department of MedicineUniversity of AucklandAucklandNew Zealand

Personalised recommendations