The clinical significance of osteoporosis is in the occurrence of fractures and re-fractures. The main risk factor of sustaining a fracture is a previous one, but a recent fracture is a better fracture risk factor than fracture history. The role of the recency of fracture has been shown for both vertebral and non-vertebral fracture risk. This imminent risk is explained by both bone-related factors (underlying osteoporosis) and fall-related factors (including those related to postfracture care). Such a short-term increased risk has been shown also in patients initiating corticosteroids and in frail osteoporotic subjects with central nervous system (CNS) diseases or drugs targeting CNS, and thus a high risk of falls. Patients with an imminent (i.e. 2 years) risk of fracture or refracture should be identified in priority in order to receive an immediate treatment and a program of fall prevention.
KeywordsFracture Imminent Osteoporosis Treatment
Compliance with ethical standards
Conflict of interest
Christian Roux received research grants and/or honoraria from the following: Alexion, Amgen, Lilly, and UCB. Karine Briot received research grants and/or honoraria from the following: Amgen, Lilly, MSD, and PFIZER.
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