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Osteoporosis International

, Volume 27, Issue 4, pp 1389–1399 | Cite as

Dietary magnesium intake, bone mineral density and risk of fracture: a systematic review and meta-analysis

  • M. Farsinejad-Marj
  • P. Saneei
  • A. Esmaillzadeh
Review

Abstract

Dietary magnesium intake has been related to osteoporosis and risk of fractures in earlier studies; however, findings were conflicting. This meta-analysis indicated that high magnesium intake was not associated with increased risk of fracture; however, a positive marginally significant correlation was found between magnesium intake and bone mineral density (BMD) in total hip as well as in femoral neck. Although there is some evidence on the association between magnesium intake, BMD and fractures, no previous study has summarized findings in this regard. We aimed to systematically review the current evidence on this association and to perform a meta-analysis of observational studies. We searched MEDLINE, Scopus, EMBASE and Google Scholar up to January 2015 for studies that examined the relationship between magnesium intake and BMD or fracture. Studies that had reported correlation coefficients between magnesium intake and BMD or those that reported odds ratios (ORs) or relative risks (RRs) for risk of fracture in different sites were included. In total, 12 studies were included in the meta-analysis. We found that high intakes of magnesium were not significantly associated with risk of total hip fracture (summary effect size 1.92; 95 % CI 0.81, 4.55) or total fractures (1.01; 0.94–1.07). Combining four effect sizes, a positive marginally significant correlation was observed between magnesium intake and total BMD (pooled r 0.16; 95 % CI 0.001, 032). Based on nine effect sizes, we found a marginally significant association between magnesium intake and femoral neck BMD (0.14; 0.001, 0.28). However, no significant correlation was found between magnesium intake and BMD in lumbar spine (0.09; −0.01, 0.19). We found that high intakes of magnesium were not associated with increased risk of hip and total fractures. There was a positive marginally significant correlation between magnesium intake and BMD in femoral neck and total hip. No significant correlations were observed between magnesium intake and BMD in lumbar spine.

Keywords

Bone mineral density Fracture Magnesium intake Meta-analysis 

Notes

Acknowledgments

This study was financially supported by the Research Council of the Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Compliance with ethical standards

Conflicts of interest

None.

References

  1. 1.
    Rivas A, Romero A, Mariscal-Arcas M, Monteagudo C, Feriche B, Lorenzo ML, Olea F (2013) Mediterranean diet and bone mineral density in two age groups of women. Int J Food Sci Nutr 64:155–161CrossRefPubMedGoogle Scholar
  2. 2.
    Irani AD, Poorolajal J, Khalilian A, Esmailnasab N, Cheraghi Z (2013) Prevalence of osteoporosis in Iran: a meta-analysis. J Res Med Sci 18:759–66PubMedPubMedCentralGoogle Scholar
  3. 3.
    Liberato SC, Bressan J, Hills AP (2013) The role of physical activity and diet on bone mineral indices in young men: a cross-sectional study. J Int Soc Sports Nutr 10:43CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Gullberg B, Johnell O, Kanis JA (1997) World-wide projections for hip fracture. Osteoporos Int 7:407–13CrossRefPubMedGoogle Scholar
  5. 5.
    Feart C, Lorrain S, Ginder Coupez V, Samieri C, Letenneur L, Paineau D, Barberger-Gateau P (2013) Adherence to a Mediterranean diet and risk of fractures in French older persons. Osteoporos Int 24:3031–3041CrossRefPubMedGoogle Scholar
  6. 6.
    Yoon EH, Noh H, Lee HM, Hwang HS, Park HK, Park YS (2012) Bone mineral density and food-frequency in Korean adults: the 2008 and 2009 Korea National Health and Nutrition Examination Survey. Korean J Fam Med 33:287–295CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    Shin S, Hong K, Kang SW, Joung H (2013) A milk and cereal dietary pattern is associated with a reduced likelihood of having a low bone mineral density of the lumbar spine in Korean adolescents. Nutr Res 33:59–66CrossRefPubMedGoogle Scholar
  8. 8.
    Karamati M, Yousefian-Sanni M, Shariati-Bafghi SE, Rashidkhani B (2014) Major nutrient patterns and bone mineral density among postmenopausal Iranian women. Calcif Tissue Int 94:648–658CrossRefPubMedGoogle Scholar
  9. 9.
    Tucker KL, Hannan MT, Chen H, Cupples LA, Wilson PW, Kiel DP (1999) Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr 69:727–736CrossRefPubMedGoogle Scholar
  10. 10.
    Bounds W, Skinner J, Carruth BR, Ziegler P (2005) The relationship of dietary and lifestyle factors to bone mineral indexes in children. J Am Diet Assoc 105:735–741CrossRefPubMedGoogle Scholar
  11. 11.
    Nakamura K, Ueno K, Nishiwaki T, Saito T, Tsuchiya Y, Yamamoto M (2007) Magnesium intake and bone mineral density in young adult women. Magnes Res 20:250–253PubMedGoogle Scholar
  12. 12.
    Carlson AR, Smith MA, McCarthy MS (2013) Diet, physical activity, and bone density in soldiers before and after deployment. US Army Med Dep J 25–30Google Scholar
  13. 13.
    Aydin H, Deyneli O, Yavuz D, Gozu H, Mutlu N, Kaygusuz I, Akalin S (2010) Short-term oral magnesium supplementation suppresses bone turnover in postmenopausal osteoporotic women. Biol Trace Elem Res 133:136–143CrossRefPubMedGoogle Scholar
  14. 14.
    Abraham GE, Grewal H (1990) A total dietary program emphasizing magnesium instead of calcium. Effect on the mineral density of calcaneous bone in postmenopausal women on hormonal therapy. J Reprod Med 35:503–507PubMedGoogle Scholar
  15. 15.
    Stendig-Lindberg G, Tepper R, Leichter I (1993) Trabecular bone density in a two year controlled trial of peroral magnesium in osteoporosis. Magnes Res 6:155–163PubMedGoogle Scholar
  16. 16.
    Key TJ, Appleby PN, Spencer EA, Roddam AW, Neale RE, Allen NE (2007) Calcium, diet and fracture risk: a prospective study of 1898 incident fractures among 34 696 British women and men. Public Health Nutr 10:1314–1320CrossRefPubMedGoogle Scholar
  17. 17.
    Pinheiro MM, Schuch NJ, Genaro PS, Ciconelli RM, Ferraz MB, Martini LA (2009) Nutrient intakes related to osteoporotic fractures in men and women—the Brazilian Osteoporosis Study (BRAZOS). Nutr J 8:6CrossRefPubMedPubMedCentralGoogle Scholar
  18. 18.
    Orchard TS, Larson JC, Alghothani N, Bout-Tabaku S, Cauley JA, Chen Z, LaCroix AZ, Wactawski-Wende J, Jackson RD (2014) Magnesium intake, bone mineral density, and fractures: results from the Women’s Health Initiative Observational Study. Am J Clin Nutr 99:926–933CrossRefPubMedPubMedCentralGoogle Scholar
  19. 19.
    Saito N, Tabata N, Saito S, Andou Y, Onaga Y, Iwamitsu A, Sakamoto M, Hori T, Sayama H, Kawakita T (2004) Bone mineral density, serum albumin and serum magnesium. J Am Coll Nutr 23:701s–703sCrossRefPubMedGoogle Scholar
  20. 20.
    Gunes AM, Can E, Saglam H, Ilcol YO, Baytan B (2010) Assessment of bone mineral density and risk factors in children completing treatment for acute lymphoblastic leukemia. J Pediatr Hematol Oncol 32:e102–107CrossRefPubMedGoogle Scholar
  21. 21.
    Razmandeh R, Nasli-Esfahani E, Heydarpour R, Faridbod F, Ganjali MR, Norouzi P, Larijani B, Khoda-Amorzideh D (2014) Association of zinc, copper and magnesium with bone mineral density in Iranian postmenopausal women—a case control study. J Diabetes Metab Disord 13:43CrossRefPubMedPubMedCentralGoogle Scholar
  22. 22.
    Schanler RJ, Smith LG Jr, Burns PA (1997) Effects of long-term maternal intravenous magnesium sulfate therapy on neonatal calcium metabolism and bone mineral content. Gynecol Obstet Invest 43:236–241CrossRefPubMedGoogle Scholar
  23. 23.
    Jones G, Riley MD, Dwyer T (2000) Maternal diet during pregnancy is associated with bone mineral density in children: a longitudinal study. Eur J Clin Nutr 54:749–756CrossRefPubMedGoogle Scholar
  24. 24.
    Malaeb SN, Rassi AI, Haddad MC, Seoud MA, Yunis KA (2004) Bone mineralization in newborns whose mothers received magnesium sulphate for tocolysis of premature labour. Pediatr Radiol 34:384–386CrossRefPubMedGoogle Scholar
  25. 25.
    Tobias JH, Steer CD, Emmett PM, Tonkin RJ, Cooper C, Ness AR (2005) Bone mass in childhood is related to maternal diet in pregnancy. Osteoporos Int 16:1731–1741CrossRefPubMedGoogle Scholar
  26. 26.
    Ganpule A, Yajnik CS, Fall CH, Rao S, Fisher DJ, Kanade A, Cooper C, Naik S, Joshi N, Lubree H et al (2006) Bone mass in Indian children—relationships to maternal nutritional status and diet during pregnancy: the Pune Maternal Nutrition Study. J Clin Endocrinol Metab 91:2994–3001CrossRefPubMedGoogle Scholar
  27. 27.
    Kaplan W, Haymond MW, McKay S, Karaviti LP (2006) Osteopenic effects of MgSO4 in multiple pregnancies. J Pediatr Endocrinol Metab 19:1225–1230CrossRefPubMedGoogle Scholar
  28. 28.
    Nassar AH, Sakhel K, Maarouf H, Naassan GR, Usta IM (2006) Adverse maternal and neonatal outcome of prolonged course of magnesium sulfate tocolysis. Acta Obstet Gynecol Scand 85:1099–1103CrossRefPubMedGoogle Scholar
  29. 29.
    Yin J, Dwyer T, Riley M, Cochrane J, Jones G (2010) The association between maternal diet during pregnancy and bone mass of the children at age 16. Eur J Clin Nutr 64:131–137CrossRefPubMedGoogle Scholar
  30. 30.
    Yokoyama K, Takahashi N, Yada Y, Koike Y, Kawamata R, Uehara R, Kono Y, Honma Y, Momoi MY (2010) Prolonged maternal magnesium administration and bone metabolism in neonates. Early Hum Dev 86:187–191CrossRefPubMedGoogle Scholar
  31. 31.
    Heppe DH, Medina-Gomez C, Hofman A, Franco OH, Rivadeneira F, Jaddoe VW (2013) Maternal first-trimester diet and childhood bone mass: the Generation R Study. Am J Clin Nutr 98:224–232CrossRefPubMedGoogle Scholar
  32. 32.
    Michaelsson K, Holmberg L, Ljunghall S, Mallmin H, Persson PG, Wolk A (1996) Effect of prefracture versus postfracture dietary assessment on hip fracture risk estimates. Int J Epidemiol 25:403–410CrossRefPubMedGoogle Scholar
  33. 33.
    Lumbers M, New SA, Gibson S, Murphy MC (2001) Nutritional status in elderly female hip fracture patients: comparison with an age-matched home living group attending day centres. Br J Nutr 85:733–740CrossRefPubMedGoogle Scholar
  34. 34.
    Burrows M, Nevill AM, Bird S, Simpson D (2003) Physiological factors associated with low bone mineral density in female endurance runners. Br J Sports Med 37:67–71CrossRefPubMedPubMedCentralGoogle Scholar
  35. 35.
    Miyabara Y, Onoe Y, Harada A, Kuroda T, Sasaki S, Ohta H (2007) Effect of physical activity and nutrition on bone mineral density in young Japanese women. J Bone Miner Metab 25:414–418CrossRefPubMedGoogle Scholar
  36. 36.
    Pedone C, Napoli N, Pozzilli P, Lauretani F, Bandinelli S, Ferrucci L, Antonelli-Incalzi R (2010) Quality of diet and potential renal acid load as risk factors for reduced bone density in elderly women. Bone 46:1063–1067CrossRefPubMedGoogle Scholar
  37. 37.
    Snead DB, Stubbs CC, Weltman JY, Evans WS, Veldhuis JD, Rogol AD, Teates CD, Weltman A (1992) Dietary patterns, eating behaviors, and bone mineral density in women runners. Am J Clin Nutr 56:705–711CrossRefPubMedGoogle Scholar
  38. 38.
    Tesar R, Notelovitz M, Shim E, Kauwell G, Brown J (1992) Axial and peripheral bone density and nutrient intakes of postmenopausal vegetarian and omnivorous women. Am J Clin Nutr 56:699–704CrossRefPubMedGoogle Scholar
  39. 39.
    Tucker KL, Chen H, Hannan MT, Cupples LA, Wilson PW, Felson D, Kiel DP (2002) Bone mineral density and dietary patterns in older adults: the Framingham Osteoporosis Study. Am J Clin Nutr 76:245–252CrossRefPubMedGoogle Scholar
  40. 40.
    Okubo H, Sasaki S, Horiguchi H, Oguma E, Miyamoto K, Hosoi Y, Kim MK, Kayama F (2006) Dietary patterns associated with bone mineral density in premenopausal Japanese farmwomen. Am J Clin Nutr 83:1185–1192CrossRefPubMedGoogle Scholar
  41. 41.
    McNaughton SA, Wattanapenpaiboon N, Wark JD, Nowson CA (2011) An energy-dense, nutrient-poor dietary pattern is inversely associated with bone health in women. J Nutr 141:1516–1523CrossRefPubMedGoogle Scholar
  42. 42.
    Pedone C, Napoli N, Pozzilli P, Rossi FF, Lauretani F, Bandinelli S, Ferrucci L, Antonelli-Incalzi R (2011) Dietary pattern and bone density changes in elderly women: a longitudinal study. J Am Coll Nutr 30:149–154CrossRefPubMedGoogle Scholar
  43. 43.
    Hung JW, Tsai MY, Yang BY, Chen JF (2005) Maternal osteoporosis after prolonged magnesium sulfate tocolysis therapy: a case report. Arch Phys Med Rehabil 86:146–149CrossRefPubMedGoogle Scholar
  44. 44.
    Wedig KE, Kogan J, Schorry EK, Whitsett JA (2006) Skeletal demineralization and fractures caused by fetal magnesium toxicity. J Perinatol 26:371–374CrossRefPubMedGoogle Scholar
  45. 45.
    Kanazawa I, Yamamoto M, Yamaguchi T, Yamauchi M, Yano S, Sugimoto T (2007) A case of magnesium deficiency associated with insufficient parathyroid hormone action and severe osteoporosis. Endocr J 54:935–940CrossRefPubMedGoogle Scholar
  46. 46.
    Sivas F, Gunesen O, Ozoran K, Alemdaroglu E (2007) Osteomalacia from Mg-containing antacid: a case report of bilateral hip fracture. Rheumatol Int 27:679–681CrossRefPubMedGoogle Scholar
  47. 47.
    Yaegashi Y, Onoda T, Tanno K, Kuribayashi T, Sakata K, Orimo H (2008) Association of hip fracture incidence and intake of calcium, magnesium, vitamin D, and vitamin K. Eur J Epidemiol 23:219–225CrossRefPubMedGoogle Scholar
  48. 48.
    Dahl C, Sogaard AJ, Tell GS, Flaten TP, Hongve D, Omsland TK, Holvik K, Meyer HE, Aamodt G (2013) Nationwide data on municipal drinking water and hip fracture: could calcium and magnesium be protective? A NOREPOS study. Bone 57:84–91CrossRefPubMedGoogle Scholar
  49. 49.
    Freudenheim JL, Johnson NE, Smith EL (1986) Relationships between usual nutrient intake and bone-mineral content of women 35-65 years of age: longitudinal and cross-sectional analysis. Am J Clin Nutr 44:863–76CrossRefPubMedGoogle Scholar
  50. 50.
    Yano K, Heilbrun LK, Wasnich RD, Hankin JH, Vogel JM (1985) The relationship between diet and bone mineral content of multiple skeletal sites in elderly Japanese-American men and women living in Hawaii. Am J Clin Nutr 42:877–888CrossRefPubMedGoogle Scholar
  51. 51.
    Tranquilli AL, Lucino E, Garzetti GG, Romanini C (1994) Calcium, phosphorus and magnesium intakes correlate with bone mineral content in postmenopausal women. Gynecol Endocrinol 8:55–58CrossRefPubMedGoogle Scholar
  52. 52.
    Quintas ME, Ortega RM, Lopez-Sobaler AM, Garrido G, Requejo AM (2003) Influence of dietetic and anthropometric factors and of the type of sport practised on bone density in different groups of women. Eur J Clin Nutr 57(Suppl 1):S58–62CrossRefPubMedGoogle Scholar
  53. 53.
    Abraham R, Walton J, Russell L, Wolman R, Wardley-Smith B, Green JR, Mitchell A, Reeve J (2006) Dietary determinants of post-menopausal bone loss at the lumbar spine: a possible beneficial effect of iron. Osteoporos Int 17:1165–1173CrossRefPubMedGoogle Scholar
  54. 54.
    Houtkooper LB, Ritenbaugh C, Aickin M, Lohman TG, Going SB, Weber JL, Greaves KA, Boyden TW, Pamenter RW, Hall MC (1995) Nutrients, body composition and exercise are related to change in bone mineral density in premenopausal women. J Nutr 125:1229–1237PubMedGoogle Scholar
  55. 55.
    Tucker KL, Hannan MT, Kiel DP (2001) The acid-base hypothesis: diet and bone in the Framingham osteoporosis study. Eur J Nutr 40:231–237CrossRefPubMedGoogle Scholar
  56. 56.
    DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177–188CrossRefPubMedGoogle Scholar
  57. 57.
    Kaptoge S, Welch A, McTaggart A, Mulligan A, Dalzell N, Day NE, Bingham S, Khaw KT, Reeve J (2003) Effects of dietary nutrients and food groups on bone loss from the proximal femur in men and women in the 7th and 8th decades of age. Osteoporos Int 14:418–428CrossRefPubMedGoogle Scholar
  58. 58.
    Macdonald HM, New SA, Golden MH, Campbell MK, Reid DM (2004) Nutritional associations with bone loss during the menopausal transition: evidence of a beneficial effect of calcium, alcohol, and fruit and vegetable nutrients and of a detrimental effect of fatty acids. Am J Clin Nutr 79:155–165CrossRefPubMedGoogle Scholar
  59. 59.
    Chan R, Woo J, Lau W, Leung J, Xu L, Zhao X, Yu W, Lau E, Pocock N (2009) Effects of lifestyle and diet on bone health in young adult Chinese women living in Hong Kong and Beijing. Food Nutr Bull 30:370–378CrossRefPubMedGoogle Scholar
  60. 60.
    Chan R, Woo J, Leung J (2011) Effects of food groups and dietary nutrients on bone loss in elderly Chinese population. J Nutr Health Aging 15:287–294CrossRefPubMedGoogle Scholar
  61. 61.
    Michaelsson K, Holmberg L, Mallmin H, Sorensen S, Wolk A, Bergstrom R, Ljunghall S (1995) Diet and hip fracture risk: a case-control study. Study group of the Multiple Risk Survey on Swedish Women for Eating Assessment. Int J Epidemiol 24:771–782CrossRefPubMedGoogle Scholar
  62. 62.
    New SA, Bolton-Smith C, Grubb DA, Reid DM (1997) Nutritional influences on bone mineral density: a cross-sectional study in premenopausal women. Am J Clin Nutr 65:1831–1839CrossRefPubMedGoogle Scholar
  63. 63.
    New SA, Robins SP, Campbell MK, Martin JC, Garton MJ, Bolton-Smith C, Grubb DA, Lee SJ, Reid DM (2000) Dietary influences on bone mass and bone metabolism: further evidence of a positive link between fruit and vegetable consumption and bone health? Am J Clin Nutr 71:142–151CrossRefPubMedGoogle Scholar
  64. 64.
    Jones G, Riley MD, Whiting S (2001) Association between urinary potassium, urinary sodium, current diet, and bone density in prepubertal children. Am J Clin Nutr 73:839–844CrossRefPubMedGoogle Scholar
  65. 65.
    Egami I, Wakai K, Kunitomo H, Tamakoshi A, Ando M, Nakayama T, Ohno Y (2003) Associations of lifestyle factors with bone mineral density among male university students in Japan. J Epidemiol 13:48–55CrossRefPubMedGoogle Scholar
  66. 66.
    McCabe LD, Martin BR, McCabe GP, Johnston CC, Weaver CM, Peacock M (2004) Dairy intakes affect bone density in the elderly. Am J Clin Nutr 80:1066–1074CrossRefPubMedGoogle Scholar
  67. 67.
    Ryder KM, Shorr RI, Bush AJ, Kritchevsky SB, Harris T, Stone K, Cauley J, Tylavsky FA (2005) Magnesium intake from food and supplements is associated with bone mineral density in healthy older white subjects. J Am Geriatr Soc 53:1875–1880CrossRefPubMedGoogle Scholar
  68. 68.
    Esterle L, Sabatier JP, Guillon-Metz F, Walrant-Debray O, Guaydier-Souquieres G, Jehan F, Garabedian M (2009) Milk, rather than other foods, is associated with vertebral bone mass and circulating IGF-1 in female adolescents. Osteoporos Int 20:567–575CrossRefPubMedGoogle Scholar
  69. 69.
    Farrell VA, Harris M, Lohman TG, Going SB, Thomson CA, Weber JL, Houtkooper LB (2009) Comparison between dietary assessment methods for determining associations between nutrient intakes and bone mineral density in postmenopausal women. J Am Diet Assoc 109:899–904CrossRefPubMedPubMedCentralGoogle Scholar
  70. 70.
    Woo J, Kwok T, Leung J, Tang N (2009) Dietary intake, blood pressure and osteoporosis. J Hum Hypertens 23:451–455CrossRefPubMedGoogle Scholar
  71. 71.
    Matias CN, Santos DA, Monteiro CP, Vasco AM, Baptista F, Sardinha LB, Laires MJ, Silva AM (2012) Magnesium intake mediates the association between bone mineral density and lean soft tissue in elite swimmers. Magnes Res 25:120–125PubMedGoogle Scholar
  72. 72.
    Poruk KE, Davis RH, Smart AL, Chisum BS, Lasalle BA, Chan GM, Gill G, Reyna SP, Swoboda KJ (2012) Observational study of caloric and nutrient intake, bone density, and body composition in infants and children with spinal muscular atrophy type I. Neuromuscul Disord 22:966–973CrossRefPubMedPubMedCentralGoogle Scholar
  73. 73.
    Abrams SA, Chen Z, Hawthorne KM (2014) Magnesium metabolism in 4-year-old to 8-year-old children. J Bone Miner Res 29:118–122CrossRefPubMedGoogle Scholar
  74. 74.
    Gunn CA, Weber JL, Kruger MC (2014) Diet, weight, cytokines and bone health in postmenopausal women. J Nutr Health Aging 18:479–486CrossRefPubMedGoogle Scholar
  75. 75.
    Liu K, Liu P, Liu R, Wu X, Cai M (2015) Relationship between serum leptin levels and bone mineral density: a systematic review and meta-analysis. Clin Chim Acta 444:260–3CrossRefPubMedGoogle Scholar
  76. 76.
    Dai Q, Shrubsole MJ, Ness RM, Schlundt D, Cai Q, Smalley WE et al (2007) The relation of magnesium and calcium intakes and a genetic polymorphism in the magnesium transporter to colorectal neoplasia risk. Am J Clin Nutr 86:743–51CrossRefPubMedPubMedCentralGoogle Scholar
  77. 77.
    Shechter M (2010) Magnesium and cardiovascular system. Magnes Res 23:60–72PubMedGoogle Scholar
  78. 78.
    Mahdavi-Roshan M, Ebrahimi M, Ebrahimi A (2015) Copper, magnesium, zinc and calcium status in osteopenic and osteoporotic post-menopausal women. Clin Cases Miner Bone Metab 12:18–21PubMedPubMedCentralGoogle Scholar
  79. 79.
    Nieves JW (2005) Osteoporosis: the role of micronutrients. Am J Clin Nutr 81:1232S–1239SCrossRefPubMedGoogle Scholar

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2015

Authors and Affiliations

  • M. Farsinejad-Marj
    • 1
    • 2
  • P. Saneei
    • 1
    • 2
    • 3
  • A. Esmaillzadeh
    • 1
    • 2
    • 4
  1. 1.Food Security Research CenterIsfahan University of Medical SciencesIsfahanIran
  2. 2.Department of Community Nutrition, School of Nutrition and Food ScienceIsfahan University of Medical SciencesIsfahanIran
  3. 3.Students’ Research CommitteeIsfahan University of Medical SciencesIsfahanIran
  4. 4.Department of Community Nutrition, School of Nutritional Sciences and DieteticsTehran University of Medical SciencesTehranIran

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