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Osteoporosis International

, Volume 26, Issue 11, pp 2561–2572 | Cite as

Circulating monocytes: an appropriate model for bone-related study

  • Y. Zhou
  • H.-W. Deng
  • H. ShenEmail author
Review Article

Abstract

Summary

Peripheral blood monocytes (PBMs) are an important source of precursors of osteoclasts, the bone-resorbing cells and the cytokines produced by PBMs that have profound effects on osteoclast differentiation, activation, and apoptosis. So PBMs represent a highly valuable and unique working cell model for bone-related study.

Finding an appropriate working cell model for clinical and (epi-)genomic studies of human skeletal disorders is a challenge. Peripheral blood monocytes (PBMs) can give rise to osteoclasts, the bone-resorbing cells. Particularly, PBMs provide the sole source of osteoclast precursors for adult peripheral skeleton where the bone marrow is normally hematopoietically inactive. PBMs can secrete potent pro- and anti-inflammatory cytokines, which are important for osteoclast differentiation, activation, and apoptosis. Reduced production of PBM cytokines represents a major mechanism for the inhibitory effects of sex hormones on osteoclastogenesis and bone resorption. Abnormalities in PBMs have been linked to various skeletal disorders/traits, strongly supporting for the biological relevance of PBMs with bone metabolism and disorders. Here, we briefly review the origin and further differentiation of PBMs. In particular, we discuss the close relationship between PBMs and osteoclasts, and highlight the utility of PBMs in study the pathophysiological mechanisms underlying various skeletal disorders.

Keywords

Osteoclast Peripheral blood monocytes Skeletal disorders 

Notes

Acknowledgments

The investigators of this work were partially supported by grants from the NIH (R01AG026564, R01AR050496, and R01AR057049) and the Edward G. Schlieder Endowment as well as the Drs. W. C. Tsai and P. T. Kung Professorship in Biostatistics from Tulane University.

Conflicts of interest

None

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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2015

Authors and Affiliations

  1. 1.Center for Bioinformatics and Genomics, Department of Biostatistics and BioinformaticsTulane UniversityNew OrleansUSA
  2. 2.Cell and Molecular Biology DepartmentTulane UniversityNew OrleansUSA
  3. 3.Center for Bioinformatics and Genomics, Department of Biostatistics and Bioinformatics, School of Public Health and Tropical MedicineTulane UniversityNew OrleansUSA

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