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Osteoporosis International

, Volume 26, Issue 10, pp 2491–2499 | Cite as

Exercise and fractures in postmenopausal women. Final results of the controlled Erlangen Fitness and Osteoporosis Prevention Study (EFOPS)

  • W. Kemmler
  • M. Bebenek
  • M. Kohl
  • S. von Stengel
Original Article

Abstract

Summary

The EFOPS trial clearly established the positive effect of long-term exercise on clinical low-trauma fractures in postmenopausal women at risk. Bearing in mind that the complex anti-fracture exercise protocols also affect a large variety of diseases of increased age, we strongly encourage older adults to perform multipurpose exercise programs.

Introduction

Physical exercise may be an efficient option for autonomous fracture prevention during increasing age. The aim of the study was to evaluate the effect of exercise on clinical overall fracture incidence and bone mineral density (BMD) in elderly subjects at risk.

Methods

In 1998 initially, 137 early-postmenopausal, osteopenic women living in Erlangen-Nuremberg, Germany, were included in the EFOPS trial. Subjects of the exercise group (EG; n = 86) conducted two supervised group and two home exercise sessions/week while the control group (CG; n = 51) was requested to maintain their physical activity. Primary study endpoints were clinical overall low-trauma fractures determined by questionnaires, structured interviews, and BMD at the lumbar spine and femoral neck assessed by dual-energy X-ray absorptiometry.

Results

In 2014, 105 subjects (EG: n = 59 vs. CG: n = 46) representing 1680 participant-years were included in the 16-year follow-up analysis. Risk ratio in the EG for overall low-trauma fractures was 0.51 (95 % confidence interval (95 % CI) 0.23 to 0.97, p = .046), rate ratio was 0.42 (95 % CI 0.20 to 0.86, p = .018). Based on comparable baseline values, lumbar spine (MV −1.5 %, 95 % CI −0.1 to −2.8 vs. −5.8 %, −3.3 to −7.2 %) and femoral neck (−6.5 %, −5.2 to −7.7 vs. −9.6 %, −8.2 to 11.1 %) BMD decreased in both groups; however, the reduction was more pronounced in the CG (p ≤ .001).

Conclusion

This study clearly evidenced the high anti-fracture efficiency of multipurpose exercise programs. Considering furthermore the favorable effect of exercise on most other risk factors of increasing age, we strongly encourage older adults to perform multipurpose exercise programs.

Keywords

Bone mineral density Clinical fractures Exercise Osteoporosis 

Notes

Acknowledgments

We gratefully acknowledge the support of the nonprofit institutions “Behinderten und Rehabilitations Sportverband Bayern”, “Netzwerk Knochengesundheit,” and the Institute of Sport and Sport Science FAU Erlangen-Nuremberg. We also thank Sanofi-Synthelabo GmbH (Henning, Berlin, Germany) who supplied Ca and Vit D for the first five study years and the supply of elastic bands by TheraBand™ (Akron, Ohio, USA).

Conflicts of interest

None.

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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2015

Authors and Affiliations

  • W. Kemmler
    • 1
  • M. Bebenek
    • 1
  • M. Kohl
    • 2
  • S. von Stengel
    • 1
  1. 1.Institute of Medical PhysicsUniversity of ErlangenErlangenGermany
  2. 2.Department of Medical and Life SciencesUniversity of FurtwangenFurtwangenGermany

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