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Osteoporosis International

, Volume 26, Issue 7, pp 1989–1995 | Cite as

Serum uric acid is associated with quantitative ultrasound parameters in men: data from the Camargo cohort

  • J. L. HernándezEmail author
  • D. Nan
  • J. Martínez
  • E. Pariente
  • I. Sierra
  • J. González-Macías
  • J. M. Olmos
Original Article

Abstract

Summary

This study analyzes the association between serum uric acid levels and heel quantitative ultrasound (QUS) parameters in men aged 50 or more from the Camargo cohort. We found that higher serum uric acid levels are positively associated with all QUS measurements, suggesting a better bone quality in men with elevated serum uric acid values.

Introduction

Higher serum uric acid concentrations have been associated with higher bone mineral density and lower prevalence of fractures. However, there are no studies that have assessed the bone quality properties in Caucasians. Therefore, we have analyzed the association between quantitative ultrasound (QUS) and serum uric acid levels in adult men from a population-based cohort.

Methods

A total of 868 men older than 50 were recruited from a larger cohort (Camargo Cohort) after excluding those with any known condition or drug treatment with a possible influence on bone metabolism, or those with a previous diagnosis of gout or taking hipouricemic agents. Bone turnover markers (PINP and CTX), 25OH-vitamin D and PTH levels were measured by electrochemiluminiscence. BMD was determined by DXA, and heel QUS with a gel-coupled device.

Results

Lumbar, femoral neck and total hip BMD was significantly higher in men with higher serum uric acid levels. QUS parameters were also significantly higher in men with high uric acid levels than those with lower values, and increased continuously across quartiles after adjustment for confounding variables. In multiple regression analysis, serum uric acid was significantly associated with all QUS parameters. Finally, men with serum acid levels above median showed higher values in all the QUS parameters than men with lower values.

Conclusions

Higher serum uric acid levels in men older than 50 years are positively associated with QUS parameters. These data might suggest a better bone quality in men with elevated serum uric acid values.

Keywords

Bone mineral density Bone turnover markers Broadband ultrasound attenuation Heel ultrasound Speed of sound Uric acid 

Notes

Acknowledgment

This study is supported by a grant from the Instituto de Salud Carlos III-FIS, Spain (PI11/01092).

Conflicts of interest

None.

References

  1. 1.
    Stotz M, Szkandera J, Seidel J, Stojakovic T, Samonigg H, Reitz D, Gary T, Kornprat P, Schaberl-Moser R, Hoefler G, Gerger A, Pichler M (2014) Evaluation of uric acid as a prognostic blood-based marker in a large cohort of pancreatic cancer patients. PLoS One 9:e104730PubMedCentralPubMedCrossRefGoogle Scholar
  2. 2.
    Horsfall LJ, Nazareth I, Petersen I (2014) Serum uric acid and the risk of respiratory disease: a population-based cohort study. Thorax 69:1021–1026PubMedCentralPubMedCrossRefGoogle Scholar
  3. 3.
    Liang DK, Bai XJ, Wu B, Han LL, Wang XN, Yang J, Chen XM (2014) Associations between bone mineral density and subclinical atherosclerosis: a cross-sectional study of a Chinese population. J Clin Endocrinol Metab 99:469–477PubMedCrossRefGoogle Scholar
  4. 4.
    Newgard CB, Pessin JE (2014) Recent progress in metabolic signaling pathways regulating aging and life span. J Gerontol A Biol Sci Med Sci 69(Suppl 1):S21–S27PubMedCentralPubMedCrossRefGoogle Scholar
  5. 5.
    Wauquier F (2009) Oxidative stress in bone remodeling and disease. Trends Mol Med 15:468–471PubMedCrossRefGoogle Scholar
  6. 6.
    Yalin S, Bagis S, Polat G, Dogruer N, Cenk Aksit S, Hatungil R, Erdogan C (2005) Is there a role of free oxygen radicals in primary male osteoporosis? Clin Exp Rheumatol 23:689–692PubMedGoogle Scholar
  7. 7.
    Nabipour I, Sambrook PN, Blyth FM, Janu MR, Waite LM, Naganathan V, Handelsman DJ, Le Couteur DG, Cumming RG, Seibel MJ (2011) Serum uric acid is associated with bone health in older men: a cross-sectional population-based study. J Bone Miner Res 26:955–964PubMedCrossRefGoogle Scholar
  8. 8.
    Kim BJ, Baek S, Ahn SH, Kim SH, Jo MW, Bae SJ, Kim HK, Choe J, Park GM, Kim YH, Lee SH, Kim GS, Koh JM (2014) Higher serum uric acid as a protective factor against incident osteoporotic fractures in Korean men: a longitudinal study using the National Claim Registry. Osteoporos Int 25:1837–1844PubMedCrossRefGoogle Scholar
  9. 9.
    Lane NE, Parimi N, Lui LY, Wise BL, Yao W, Lay YA, Cawthon PM, Orwoll E (2014) Osteoporotic Fractures in Men Study Group. Association of serum uric acid an incident nonspine fractures in elderly men: the osteoporotic fractures in men (MrOS) study. J Bone Miner Res 29:1701–1707PubMedCrossRefGoogle Scholar
  10. 10.
    Ishii S, Miyao M, Mizuno Y, Tanaka-Ishikawa M, Akishita M, Ouchi Y (2014) Association between serum uric acid and lumbar spine bone mineral density in peri- and postmenopausal Japanese women. Osteoporos Int 25:1099–1105PubMedCrossRefGoogle Scholar
  11. 11.
    Ahn SH, Lee SH, Kim BJ, Lim KH, Bae SJ, Kim EH, Kim HK, Choe JW, Koh JM, Kim GS (2013) Higher serum uric acid is associated with higher bone mass, lower bone turnover, and lower prevalence of vertebral fracture in healthy postmenopausal women. Osteoporos Int 24:2961–2970PubMedCrossRefGoogle Scholar
  12. 12.
    Makovey J, Macara M, Chen JS, Hayward CS, March L, Seibel MJ, Sambrook PN (2013) Serum uric acid plays a protective role for bone loss in peri- and postmenopausal women: a longitudinal study. Bone 52:400–406PubMedCrossRefGoogle Scholar
  13. 13.
    Zhang D, Bobulescu IA, Maalouf NM, Adams-Huet B, Poindexter J, Park S, Wei F, Chen C, Moe OW, Sakhaee K (2014) Relationship between serum uric acid and bone mineral density in the general population and in rats with experimental hyperuricemia. J Bone Miner Res. doi: 10.1002/jbmr.2430 Google Scholar
  14. 14.
    Bauer DC, Glüer CC, Cauley JA, Vogt TM, Ensrud KE, Genant HK, Black DM (1997) Broadband ultrasound attenuation predicts fractures strongly and independently of densitometry in older women. A prospective study. Study of Osteoporotic Fractures Research Group. Arch Intern Med 157:629–634PubMedCrossRefGoogle Scholar
  15. 15.
    Guglielmi G, Adams J, Link TM (2009) Quantitative ultrasound in the assessment of skeletal status. Eur Radiol 19:1837–1848PubMedCrossRefGoogle Scholar
  16. 16.
    Sritara C, Ongphiphadhanakul B, Chailurkit L, Yamwong S, Ratanachaiwong W, Sritara P (2013) Serum uric acid levels in relation to bone-related phenotypes in men and women. J Clin Densitom 16:336–340PubMedCrossRefGoogle Scholar
  17. 17.
    Hernández JL, Olmos JM, Romaña G, Llorca J, Martínez J, Castillo J, de Juan J, Pérez-Pajares I, Ruiz S, González-Macías J (2014) Influence of vitamin D status on the effect of statins on bone mineral density and bone turnover markers in postmenopausal women. J Clin Endocrinol Metab 99:3304–3309PubMedCrossRefGoogle Scholar
  18. 18.
    Hernández JL, Olmos JM, Pariente E, Martínez J, Valero C, García-Velasco P, Nan D, Llorca J, González-Macías J (2010) Metabolic syndrome and bone metabolism: the Camargo cohort study. Menopause 17:955–961PubMedCrossRefGoogle Scholar
  19. 19.
    Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D (1999) A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of diet in Renal Disease Study Group. Ann Intern Med 130:461–470PubMedCrossRefGoogle Scholar
  20. 20.
    Díez A, González-Macías J, Marín F, Abizanda M, Alvarez R, Gimeno A, Pegenaute E, Vila J (2007) Prediction of absolute risk of nonspinal fractures using clinical risk factors and heel quantitative ultrasound. Osteoporos Int 18:629–639CrossRefGoogle Scholar
  21. 21.
    Riancho JA, Valero C, Hernández JL, Olmos JM, Paule B, Zarrabeitia A, Gonzalez-Macias J (2007) Biomechanical indices of the femoral neck estimated from the standard DXA output: age- and sex-related differences. J Clin Densitom 10:39–45PubMedCrossRefGoogle Scholar
  22. 22.
    van Daele PL, Burguer H, Algra D, Hofman A, Grobbee DE, Birkenhäger JC, Pols HA (1994) Age-associated changes in ultrasound measurements of the calcaneus in men and women: the Rotterdam study. J Bone Miner Res 9:1751–1757PubMedCrossRefGoogle Scholar
  23. 23.
    Frost ML, Blake GM, Fogelman I (2001) Quantitative ultrasound and bone mineral density are equally strongly associated with risk factors for osteoporosis. J Bone Miner Res 16:406–416PubMedCrossRefGoogle Scholar
  24. 24.
    Sosa M, Saavedra P, Muñoz-Torres M, Alegre J, Gómez C, González-Macías J, Guañabens N, Hawkins F, Lozano C, Martínez M, Mosquera J, Pérez-Cano R, Quesada M, Salas E, GIUMO Study Group (2002) Quantitative ultrasound calcaneus measurements: normative data and precision in the Spanish population. Osteoporos Int 13:487–492PubMedCrossRefGoogle Scholar
  25. 25.
    Genant HK, Jergas M, Palermo L, Nevitt M, Valentin RS, Black D, Cummings SR (1996) Comparison of semiquantitative visual and quantitative morphometric assessment of prevalent and incident vertebral fractures in osteoporosis: The Study of Osteoporotic Fractures Research Group. J Bone Miner Res 11:984–996PubMedCrossRefGoogle Scholar
  26. 26.
    Maggio D, Barabani M, Pierandrei M, Polidori MC, Catani M, Mecocci P, Senin U, Pacifici R, Cherubini A (2003) Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional study. J Clin Endocrinol Metab 88:1523–1527PubMedCrossRefGoogle Scholar
  27. 27.
    Garrett IR, Boyce BF, Oreffo RO, Bonewald L, Poser J, Mundy GR (1990) Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo. J Clin Invest 85:632–639PubMedCentralPubMedCrossRefGoogle Scholar
  28. 28.
    Valdemarsson S, Lindblom P, Bergenfelz A (1998) Metabolic abnormalities related to cardiovascular risk in primary hyperparathyroidism: effects of surgical treatment. J Intern Med 244:241–249PubMedCrossRefGoogle Scholar
  29. 29.
    Takahashi S, Yamamoto T, Moriwaki Y, Tsutsumi Z, Yamakita J, Higashino K (1998) Decreased serum concentrations of 1,25(OH)2-vitamin D3 in patients with gout. Adv Exp Med Biol 431:57–60PubMedCrossRefGoogle Scholar
  30. 30.
    Cortet B, Boutry N, Dubois P, Legroux-Gérot I, Cotten A, Marchandise X (2004) Does quantitative ultrasound of bone reflect more bone mineral density than bone microarchitecture? Calcif Tissue Int 74:60–67PubMedCrossRefGoogle Scholar
  31. 31.
    Pye SR, Devakumar V, Boonen S, Borghs H, Vanderschueren D, Adams JE, Ward KA, Bartfai G, Casanueva FF, Finn JD, Forti G, Giwercman A, Han TS, Huhtaniemi IT, Kula K, Lean ME, Pendleton N, Punab M, Silman AJ, Wu FC, O’Neill TW, EMAS Study Group (2010) Influence of lifestyle factors on quantitative heel ultrasound measurements in middle-aged and elderly men. Calcif Tissue Int 86:211–219PubMedCentralCrossRefGoogle Scholar
  32. 32.
    Varenna M, Sinigaglia L, Adami S, Giannini S, Isaia G, Maggi S, Filipponi P, Di Munno O, Maugeri D, de Feo D, Crepaldi G (2005) Association of quantitative heel ultrasound with history of osteoporotic fractures in elderly men: the ESOPO study. Osteoporos Int 16:1749–1754PubMedCrossRefGoogle Scholar

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2015

Authors and Affiliations

  • J. L. Hernández
    • 1
    • 3
    Email author
  • D. Nan
    • 1
  • J. Martínez
    • 2
  • E. Pariente
    • 2
  • I. Sierra
    • 1
  • J. González-Macías
    • 1
  • J. M. Olmos
    • 1
  1. 1.Bone Metabolic Unit, Department of Internal Medicine, Hospital Universitario Marqués de Valdecilla. IDIVAL, Red Temática de Investigación Cooperativa en Envejecimiento y Fragilidad (RETICEF)University of CantabriaSantanderSpain
  2. 2.Centro de Salud CamargoSantanderSpain
  3. 3.Bone Metabolic Unit, Department of Internal MedicineUniversity of CantabriaSantanderSpain

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