Osteoporosis International

, Volume 25, Issue 6, pp 1667–1676 | Cite as

Celiac disease and risk of fracture in adults—a review

  • A. M. HjelleEmail author
  • E. Apalset
  • P. Mielnik
  • J. Bollerslev
  • K. E. A. Lundin
  • G. S. Tell


Patients with celiac disease (CD) have low bone mineral density. Evidence of increased fracture risk in these patients is conflicting, and the indication for bone mineral density screening of all adult CD patients is debated. Our aim was to review current published data on fractures in CD. Cross-sectional cohort studies and one case study were identified by searching Medline and Embase. Although the identified studies are heterogeneous and difficult to compare, the overall findings indicate a positive association between CD and risk of fracture. Adult patients with CD should be considered for bone densitometry in order to estimate fracture risk.


Bone mineral density Celiac disease Fractures Gluten enteropathy Osteoporosis 



We thank Sigrun M. Hjelle and Karl Ove Hufthammer for the editorial and statistical assistance.

Conflicts of interest



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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2014

Authors and Affiliations

  • A. M. Hjelle
    • 1
    Email author
  • E. Apalset
    • 2
    • 3
  • P. Mielnik
    • 1
  • J. Bollerslev
    • 4
    • 7
  • K. E. A. Lundin
    • 5
    • 6
    • 7
  • G. S. Tell
    • 3
  1. 1.Department of Rheumatology, Division of MedicineDistrict General Hospital of FørdeFørdeNorway
  2. 2.Department of RheumatologyHaukeland University HospitalBergenNorway
  3. 3.Department of Global Public Health and Primary CareUniversity of BergenBergenNorway
  4. 4.Section of Specialized EndocrinologyOslo University HospitalOsloNorway
  5. 5.Department of GastroenterologyOslo University Hospital RikshospitaletOsloNorway
  6. 6.Center for Immune RegulationUniversity of OsloOsloNorway
  7. 7.Faculty of MedicineUniversity of OsloOsloNorway

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