Osteoporosis International

, Volume 25, Issue 5, pp 1571–1576 | Cite as

The relationship between pulmonary function and bone mineral density in healthy nonsmoking women: the Korean National Health and Nutrition Examination Survey (KNHANES) 2010

  • Y. K. Jeon
  • M. J. Shin
  • W. J. Kim
  • S. S. Kim
  • B. H. Kim
  • S. J. Kim
  • Y. K. Kim
  • Y. B. Shin
  • I. J. Kim
Original Article

Abstract

Summary

The aim of this study was to examine the association between pulmonary function and bone mineral density (BMD) in subjects who had never smoked. Pulmonary function was associated with BMD in premenopausal, but not postmenopausal, women.

Introduction

It has been reported that low bone mass is common in patients with pulmonary disorders such as chronic obstructive pulmonary disease. However, in healthy nonsmoking women, the relationship between bone mass and pulmonary function has yet to be clarified. The object of this study was to determine whether pulmonary function is related to BMD in healthy nonsmoking women based on menopausal status.

Methods

This study was a cross-sectional study based on data obtained from the Korean National Health and Nutrition Examination Survey (KNHANES), a nationwide representative survey conducted by the Korean Ministry of Health and Welfare in 2010. This study included 456 subjects who had never smoked and analyzed data concerning pulmonary function and BMD.

Results

Functional vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) were correlated with BMD at lumbar spine, femur neck (FN), and total hip in premenopausal women (p = 0.030, p = 0.003, p = 0.019, respectively, for FVC; p = 0.015, p = 0.006, p = 0.059, respectively, for FEV1). However, FVC and FEV1 were only correlated with BMD at FN in postmenopausal women (p = 0.003 for FVC; p = 0.006 for FEV1). Body mass index (BMI), FVC, and FEV1 were significantly related with BMD at FN, even after adjusting for age and other confounding factors (β = 0.334, p < 0.001; β = 0.145, p = 0.017; and β = 0.129, p = 0.037, respectively) in premenopausal women. However, only age and BMI were correlated with BMD at FN (β = −0.268, p = 0.001 and β = 0.384, p > 0.001) in postmenopausal women after adjusting for confounding factors.

Conclusions

Pulmonary function, including FVC and FEV1 are associated with BMD at FN in healthy nonsmoking premenopausal women but not in postmenopausal women.

Keywords

Bone mineral density Osteoporosis Respiratory function Smoking 

Abbreviations

BMD

Bone mineral density

BMI

Body mass index

Ca

Calcium

25(OH)D

25-Hydroxy vitamin D

FVC

Functional vital capacity

FEV1

Forced expiratory volume in 1 s

FEV6

Forced expiratory volume in 6 s

FEF25–75

Forced expiratory flow rate of 25–75 %

PEFR

Peak expiratory flow rate

Notes

Grant support

None

Conflicts of interest

The authors declare no conflicts of interest

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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2014

Authors and Affiliations

  • Y. K. Jeon
    • 1
    • 5
  • M. J. Shin
    • 2
    • 5
  • W. J. Kim
    • 1
    • 5
  • S. S. Kim
    • 1
    • 5
  • B. H. Kim
    • 1
    • 5
  • S. J. Kim
    • 3
    • 5
  • Y. K. Kim
    • 4
  • Y. B. Shin
    • 2
    • 5
  • I. J. Kim
    • 1
    • 5
  1. 1.Division of Endocrinology, Department of Internal MedicinePusan National University School of MedicineBusanKorea
  2. 2.Department of Rehabilitation Medicine, Pusan National University HospitalPusan National University School of MedicineBusanKorea
  3. 3.Department of Nuclear MedicinePusan National University School of MedicineBusanKorea
  4. 4.Kim Yong Ki Internal Medicine ClinicBusanKorea
  5. 5.Medical Research InstitutePusan National UniversityBusanKorea

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