Genistein effects on quality of life and depression symptoms in osteopenic postmenopausal women: a 2-year randomized, double-blind, controlled study
Postmenopausal estrogen decline is implicated in several age-related physical and psychological changes in women, including decreases in perceived quality of life. The phytoestrogen genistein at a dose of 54 mg daily in osteopenic postmenopausal women after 2 years implies an improvement on quality of life and depression symptoms.
Postmenopausal estrogen decline is implicated in several age-related physical and psychological changes in women, including decreases in perceived quality of life (QoL). A number of trials with hormone therapy showed beneficial effects of the intervention on quality of life parameters. However, because of known or suspected serious side effects of conventional hormone therapy, there is a need for alternatives.
We conducted a double-blind randomized placebo-controlled trial using the isoflavone genistein, 54 mg, or placebo for 2 years. In this trial, we recruited 262 postmenopausal women aged 49 to 67 years.
At baseline, after 1 year, and at final visit, participants filled in the Short Form of 36 questions (SF-36) and the Zung Self-rating Depression Scale (ZSDS). For the placebo group, scores on all dimensions of the SF-36 decreased after 1 and 2 years. The genistein group showed increases on all dimensions of the SF-36 at the end of the study. There were, however, statistically significant differences in changes of scores between the two intervention groups. For the ZSDS, similarly, significant differences were found between groups.
In conclusion, the findings of this randomized trial showed that genistein improves quality of life (health status, life satisfaction, and depression) in osteopenic postmenopausal women.
KeywordsGenistein Osteopenia Postmenopausal Quality of life
Conflicts of interest
- 2.Hedlund LR, Gallagher JC (1989) The effect of age and menopause on bone mineral density of the proximal femur. J Bone Miner Res 44:639–642Google Scholar
- 9.Rossouw JE, Anderson GL, Prentice RL et al (2002) Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women’s Health Initiative randomized controlled trial. JAMA 2883:321–333Google Scholar
- 26.World Health Organization (1994) Quality of life assessment: international perspectives. Springer, BerlinGoogle Scholar
- 27.Golyan Tehrani SH, Mir Mohammad A, Mahmoudi M, Khaledian Z (2002) Study of quality of life and its patterns in different stages of menopause for women in Tehran. Hayat 8(3–4):33–41Google Scholar
- 33.Rodríguez-Landa JF, Hernández-Figueroa JD, Hernández-Calderón Bdel C, Saavedra M (2009) Anxiolytic-like effect of phytoestrogen genistein in rats with long-term absence of ovarian hormones in the black and white model. Prog Neuropsychopharmacol Biol Psychiatry 33(2):367–72PubMedCrossRefGoogle Scholar