Osteoporosis International

, Volume 24, Issue 5, pp 1697–1705 | Cite as

Direct healthcare costs for 5 years post-fracture in Canada

A long-term population-based assessment
  • W. D. Leslie
  • L. M. Lix
  • G. S. Finlayson
  • C. J. Metge
  • S. N. Morin
  • S. R. Majumdar
Original Article



High direct incremental healthcare costs post-fracture are seen in the first year, but total costs from a third-party healthcare payer perspective eventually fall below pre-fracture levels. We attribute this to higher mortality among fracture cases who are already the heaviest users of healthcare (“healthy survivor bias”). Economic analyses that do not account for the possibility of a long-term reduction in direct healthcare costs in the post-fracture population may systematically overestimate the total economic burden of fracture.


High healthcare costs in the first 1–2 years after an osteoporotic fracture are well recognized, but long-term costs are uncertain. We evaluated incremental costs of non-traumatic fractures up to 5 years from a third-party healthcare payer perspective.


A total of 16,198 incident fracture cases and 48,594 matched non-fracture controls were identified in the province of Manitoba, Canada (1997–2002). We calculated the difference in median direct healthcare costs for the year pre-fracture and 5 years post-fracture expressed in 2009 Canadian dollars with adjustment for expected age-related healthcare cost increases.


Incremental median costs for a hip fracture were highest in the first year ($25,306 in women, $21,396 in men), remaining above pre-fracture baseline to 5 years in women but falling below pre-fracture costs by 5 years in men. In those who survived 5 years following a hip fracture, incremental costs remained above pre-fracture costs at 5 years ($12,670 in women, $7,933 in men). Incremental costs were consistently increased for 5 years after spine fracture in women. Total incremental healthcare costs for all incident fractures combined showed a large increase over pre-fracture costs in the first year ($137 million in women, $57 million in men), but fell below pre-fracture costs within 3–4 years. Elevated total healthcare costs were seen at year 5 in women after wrist, humerus and spine fractures, but these were somewhat offset by decreases in total healthcare costs for other fractures.


High direct healthcare costs post-fracture are seen in the first year, but total costs eventually fall below pre-fracture levels. Among those who survive 5 years following a fracture, healthcare costs remain above pre-fracture levels.


Cohort study Costs Economic analysis Fractures Osteoporosis 



The authors acknowledge the Manitoba Centre for Health Policy for use of data contained in the Population Health Research Data Repository (HIPC project # 2008/2009-16). The authors also thank Mr. Mahmoud Azimaee for SAS programming support. The results and conclusions are those of the authors and no official endorsement by the Manitoba Centre for Health Policy, Manitoba Health, or other data providers is intended or should be inferred. This work was funded through a research grant from Amgen Canada Ltd. The funding source had no access to the data prior to publication, no input into the writing of the manuscript, and no input in the decision to publish the results. S.R.M. holds the Endowed Chair in Patient Health Management from the Faculties of Medicine and Dentistry and Pharmacy and Pharmaceutical Sciences (University of Alberta) and receives salary support from the Alberta Heritage Foundation for Medical Research–AIHS (Health Scholar). L.M.L. receives salary support from the University of Saskatchewan Centennial Chair Program. S.N.M. is chercheur-clinicien boursier des Fonds de la Recherche en Santé du Québec.

Conflicts of interest

William Leslie — speaker bureau: Amgen; research grants: Novartis, Amgen, Genzyme; advisory boards: Novartis, Amgen. Colleen Metge — research grant: Amgen. Lisa Lix — research grant: Amgen. Suzanne Morin — consultant to: Amgen, Novartis, Eli Lilly, Merck; speaker bureau: Amgen, Novartis; research grant: Amgen. Sumit Majumdar — none. Gregory Finlayson — none.


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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2013

Authors and Affiliations

  • W. D. Leslie
    • 1
  • L. M. Lix
    • 2
  • G. S. Finlayson
    • 2
  • C. J. Metge
    • 2
  • S. N. Morin
    • 3
  • S. R. Majumdar
    • 4
  1. 1.Department of Medicine (C5121)University of ManitobaWinnipegCanada
  2. 2.University of ManitobaWinnipegCanada
  3. 3.McGill UniversityMontrealCanada
  4. 4.University of AlbertaEdmontonCanada

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