Osteoporosis International

, Volume 23, Supplement 8, pp 841–846 | Cite as

Why subchondral bone in osteoarthritis? The importance of the cartilage bone interface in osteoarthritis

  • M. Mahjoub
  • F. BerenbaumEmail author
  • X. Houard
Bone Quality Seminars: Subchondral Bone


Osteoarthritis is a whole joint disease characterised by the disappearance of the cartilage associated with subchondral bone sclerosis, formation of osteophytes and a mild inflammation of the synovial membrane. Although all these events have been independently studied, functional interactions between these different joint tissues should exist, especially between subchondral bone and cartilage. Moreover, recent studies show that cartilage and subchondral bone act as a single functional unit. This review highlights this novel concept.


Hypertrophic chondrocytes Osteoarthritis Subchondral bone Vascular channels 



Dr. M. Majhoub was supported by an Articulum Fellowship grant. These studies were supported by the Société Française de Rhumatologie and Arthritis Fondation Courtin.

Conflicts of interest

FB has received an honorarium for participating in a workshop sponsored by Servier.


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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2012

Authors and Affiliations

  1. 1.UR4 “Ageing, Stress and Inflammation”Université Pierre et Marie CurieParis Cedex 5France
  2. 2.Department of RheumatologyAP-HP Saint-Antoine HospitalParisFrance

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