Burden of pelvis fracture: a population-based study of incidence, hospitalisation and mortality
- 569 Downloads
- 27 Citations
Abstract
Summary
The objective of this study was to describe the incidence and consequences of pelvic fractures in a community cohort. The incidence of pelvic fractures increases with age with a protective effect of higher body mass index. Almost 60% of those with a pelvic fracture required an inpatient stay, with a median of 9 days. There was a higher 3-year mortality in those admitted (17%) vs. those not admitted (6.3%). Given the substantial health burden, further work is required to identify the optimal post-fracture therapeutic strategy to improve outcomes.
Introduction
The burden of pelvis fractures is projected to increase, but there is a paucity of community-based studies describing rates, mortality and future fracture risk. We therefore estimated the age, gender and BMI-specific incidence of pelvis fracture in Catalonia (North-East Spain), and assessed hospital stay and mortality following fracture.
Methods
The SIDIAPQ database contains validated clinical information from computerised medical records of a representative sample of 30% of the population of Catalonia. We conducted a retrospective cohort study including all subjects aged ≥40 in SIDIAPQ and linked to the regional Hospital Admissions Database from 2007 to 2009. Pelvis fractures were ascertained using ICD-10 codes. Incidence and mortality rates were calculated.
Results
A total of 1,118,173 patients (582,820 women) were observed for 3 years and 1,356 had a pelvic fracture. The rate for pelvic fracture was 4.35/10,000 person-years (pyar) [95% CI 4.13–4.59] (men—2.73 [2.48–3.01]; women—5.82 [5.46–6.20]). This increased with age, peaking in those over 90 years: 29.41 [25.74–33.59]. Higher BMI was protective (HR 0.75 per SD BMI; [0.69–0.82]). Moreover, 59.1% of fractured patients were hospitalised with a median (IQR) stay of 9 (5–16) days, and after the 3-year follow-up 13.9% died (mortality rate 10.7/100 pyar [9.3–12.3]) with higher rates in those hospitalised (17.0%).
Conclusions
Pelvic fractures are associated with high rates of hospitalisation and mortality. Given this, further work is required to identify the optimal post-fracture therapeutic strategy to improve outcomes in this elderly patient group.
Keywords
Bone Epidemiology Fractures Mortality Osteoporosis PelvisNotes
Conflicts of interest
None.
References
- 1.Morris RO, Sonibare A, Green DJ, Masud T (2000) Closed pelvic fractures: characteristics and outcomes in older patients admitted to medical and geriatric wards. Postgrad Med J 76:646–650PubMedCrossRefGoogle Scholar
- 2.Pike C, Birnbaum HG, Schiller M, Sharma H, Burge R, Edgell ET (2010) Direct and indirect costs of non-vertebral fracture patients with osteoporosis in the US. PharmacoEconomics 28:395–409PubMedCrossRefGoogle Scholar
- 3.Islam S, Liu Q, Chines A, Helzner E (2009) Trend in incidence of osteoporosis-related fractures among 40- to 69-year-old women: analysis of a large insurance claims database, 2000–2005. Menopause 16:77–83PubMedCrossRefGoogle Scholar
- 4.Parkkari J, Kannus P, Niemi S, Pasanen M, Jarvinen M, Luthje P, Vuori I (1996) Secular trends in osteoporotic pelvic fractures in Finland: number and incidence of fractures in 1970–1991 and prediction for the future. Calcif Tissue Int 59:79–83PubMedCrossRefGoogle Scholar
- 5.Krappinger D, Kammerlander C, Hak DJ, Blauth M (2010) Low-energy osteoporotic pelvic fractures. Arch Orthop Trauma Surg 130:1167–1175PubMedCrossRefGoogle Scholar
- 6.Boufous S, Finch C, Close J, Day L, Lord S (2007) Hospital admissions following presentations to emergency departments for a fracture in older people. Inj Prev 13:211–214PubMedCrossRefGoogle Scholar
- 7.Ragnarsson B, Jacobsson B (1992) Epidemiology of pelvic fractures in a Swedish county. Acta Orthop Scand 63:297–300PubMedCrossRefGoogle Scholar
- 8.Garcia-Gil M, Hermosilla E, Prieto-Alhambra D, Fina F, Rossell M, Ramos R, Rodriguez J, Williams T, Van Staa T, Bolibar B (2011) Construction and validation of a scoring system for selction of high quality data in a Spanish population primary care database (SIDIAP). Informatics in Primary Care (in press)Google Scholar
- 9.Ramos R, Balló E, Marrugat J, Elosúa R, Sala J, Grau M, Vila J, Bolíbar B, García-Gil M, Martí R, Fina F, Hermosilla E, Rossell M, Muñoz MA, Prieto-Alhambra D, Quesada M (2012) Validity for use in research on vascular diseases of the SIDIAP (Information System for the Development of Research in Primary Care): the EMMA Study. Rev Esp Cardiol 65(1):29–37Google Scholar
- 10.Diez A, Puig J, Martinez MT, Diez JL, Aubia J, Vivancos J (1989) Epidemiology of fractures of the proximal femur associated with osteoporosis in Barcelona, Spain. Calcif Tissue Int 44:382–386PubMedCrossRefGoogle Scholar
- 11.Alvarez-Nebreda ML, Jimenez AB, Rodriguez P, Serra JA (2008) Epidemiology of hip fracture in the elderly in Spain. Bone 42:278–285PubMedCrossRefGoogle Scholar
- 12.IDESCAT (2011) Anuari Estadístic de Catalunya. Taxes de Mortalitat per grups d'edat i gènere. In Departament de Salut GdC (ed). BarcelonaGoogle Scholar
- 13.Pohlemann T, Tosounidis G, Bircher M, Giannoudis P, Culemann U (2007) The German Multicentre Pelvis Registry: a template for an European Expert Network? Injury 38:416–423PubMedCrossRefGoogle Scholar
- 14.Wubben RC (1996) Mortality rate of pelvic fracture patients. Wis Med J 95:702–704PubMedGoogle Scholar
- 15.Dodge G, Brison R (2010) Low-impact pelvic fractures in the emergency department. CJEM 12:509–513PubMedGoogle Scholar
- 16.Spaniolas K, Cheng JD, Gestring ML, Sangosanya A, Stassen NA, Bankey PE (2010) Ground level falls are associated with significant mortality in elderly patients. J Trauma 69:821–825PubMedCrossRefGoogle Scholar
- 17.Margolis KL, Ensrud KE, Schreiner PJ, Tabor HK (2000) Body size and risk for clinical fractures in older women. Study of Osteoporotic Fractures Research Group. Ann Intern Med 133:123–127PubMedGoogle Scholar
- 18.Premaor MO, Pilbrow L, Tonkin C, Parker RA, Compston J (2010) Obesity and fractures in postmenopausal women. J Bone Miner Res 25:292–297PubMedCrossRefGoogle Scholar
- 19.Melton LJ, 3rd, Sampson JM, Morrey BF, Ilstrup DM (1981) Epidemiologic features of pelvic fractures. Clin Orthop Relat Res 43-47Google Scholar
- 20.van Staa TP, Dennison EM, Leufkens HG, Cooper C (2001) Epidemiology of fractures in England and Wales. Bone 29:517–522PubMedCrossRefGoogle Scholar
- 21.De Laet C, Kanis JA, Oden A, Johanson H, Johnell O, Delmas P, Eisman JA, Kroger H, Fujiwara S, Garnero P, McCloskey EV, Mellstrom D, Melton LJ 3rd, Meunier PJ, Pols HA, Reeve J, Silman A, Tenenhouse A (2005) Body mass index as a predictor of fracture risk: a meta-analysis. Osteoporos Int 16:1330–1338PubMedCrossRefGoogle Scholar
- 22.Kanis J, Johnell O, Gullberg B, Allander E, Elffors L, Ranstam J, Dequeker J, Dilsen G, Gennari C, Vaz AL, Lyritis G, Mazzuoli G, Miravet L, Passeri M, Perez Cano R, Rapado A, Ribot C (1999) Risk factors for hip fracture in men from southern Europe: the MEDOS study. Mediterranean Osteoporosis Study. Osteoporos Int 9:45–54PubMedCrossRefGoogle Scholar
- 23.Burger HG, Dudley EC, Hopper JL, Groome N, Guthrie JR, Green A, Dennerstein L (1999) Prospectively measured levels of serum follicle-stimulating hormone, estradiol, and the dimeric inhibins during the menopausal transition in a population-based cohort of women. J Clin Endocrinol Metab 84:4025–4030PubMedCrossRefGoogle Scholar
- 24.Randolph JF Jr, Zheng H, Sowers MR, Crandall C, Crawford S, Gold EB, Vuga M (2010) Change in follicle-stimulating hormone and estradiol across the menopausal transition: effect of age at the final menstrual period. J Clin Endocrinol Metab 96:746–754PubMedCrossRefGoogle Scholar
- 25.Ettinger B, Pressman A, Sklarin P, Bauer DC, Cauley JA, Cummings SR (1998) Associations between low levels of serum estradiol, bone density, and fractures among elderly women: the study of osteoporotic fractures. J Clin Endocrinol Metab 83:2239–2243PubMedCrossRefGoogle Scholar
- 26.Beck TJ, Petit MA, Wu G, LeBoff MS, Cauley JA, Chen Z (2009) Does obesity really make the femur stronger? BMD, geometry, and fracture incidence in the women's health initiative—observational study. J Bone Miner Res 24:1369–1379PubMedCrossRefGoogle Scholar
- 27.Becker DJ, Yun H, Kilgore ML, Curtis JR, Delzell E, Gary LC, Saag KG, Morrisey MA (2010) Health services utilization after fractures: evidence from Medicare. J Gerontol A Biol Sci Med Sci 65:1012–1020PubMedCrossRefGoogle Scholar
- 28.Breuil V, Roux CH, Testa J, Albert C, Chassang M, Brocq O, Euller-Ziegler L (2008) Outcome of osteoporotic pelvic fractures: an underestimated severity. Survey of 60 cases. Joint Bone Spine 75:585–588PubMedCrossRefGoogle Scholar
- 29.Krappinger D, Struve P, Schmid R, Kroesslhuber J, Blauth M (2009) Fractures of the pubic rami: a retrospective review of 534 cases. Arch Orthop Trauma Surg 129:1685–1690PubMedCrossRefGoogle Scholar
- 30.Bischoff-Ferrari HA, Dawson-Hughes B, Platz A, Orav EJ, Stahelin HB, Willett WC, Can U, Egli A, Mueller NJ, Looser S, Bretscher B, Minder E, Vergopoulos A, Theiler R (2010) Effect of high-dosage cholecalciferol and extended physiotherapy on complications after hip fracture: a randomized controlled trial. Arch Intern Med 170:813–820PubMedCrossRefGoogle Scholar
- 31.Deakin DE, Boulton C, Moran CG (2007) Mortality and causes of death among patients with isolated limb and pelvic fractures. Injury 38:312–317PubMedCrossRefGoogle Scholar
- 32.Rossvoll I, Finsen V (1989) Mortality after pelvic fractures in the elderly. J Orthop Trauma 3:115–117PubMedCrossRefGoogle Scholar
- 33.van Dijk WA, Poeze M, van Helden SH, Brink PR, Verbruggen JP (2010) Ten-year mortality among hospitalised patients with fractures of the pubic rami. Injury 41:411–414PubMedCrossRefGoogle Scholar
- 34.Hill RM, Robinson CM, Keating JF (2001) Fractures of the pubic rami. Epidemiology and five-year survival. J Bone Joint Surg Br 83:1141–1144PubMedCrossRefGoogle Scholar
- 35.Taillandier J, Langue F, Alemanni M, Taillandier-Heriche E (2003) Mortality and functional outcomes of pelvic insufficiency fractures in older patients. Joint Bone Spine 70:287–289PubMedCrossRefGoogle Scholar
- 36.Rapp K, Becker C, Lamb SE, Icks A, Klenk J (2008) Hip fractures in institutionalized elderly people: incidence rates and excess mortality. J Bone Miner Res 23:1825–1831PubMedCrossRefGoogle Scholar
- 37.Currie C, Fleming S, Partridge M, Plant F, Wakeman R, Williams A (2010) The National Hip Fracture Database National Report 2010—extended version. In Partnership HQI (ed). [available from http://www.rcseng.ac.uk/news/docs/NHFD%20(final).pdf]