Osteoporosis International

, Volume 23, Issue 4, pp 1199–1212

The multiple facets of periostin in bone metabolism

Review

Abstract

Periostin is a matricellular glutamate-containing protein expressed during ontogenesis and in adult connective tissues submitted to mechanical strains including bone and, more specifically, the periosteum, periodontal ligaments, tendons, heart valves, or skin. It is also expressed in neoplastic tissues, cardiovascular and fibrotic diseases, and during wound repair. Its biological functions are extensively investigated in fields such as cardiovascular physiology or oncology. Despite its initial identification in bone, investigations of periostin functions in bone-related physiopathology are less abundant. Recently, several studies have analyzed the potential role of periostin in bone biology and suggest that periostin may be an important regulator of bone formation. The aim of this article is to provide an extensive review on the implications of periostin in bone biology and its potential use in benign and metabolic bone diseases.

Keywords

Bone quality Bone markers Bone metabolism Bone metastasis Periosteum 

Abbreviations

βig-H3 protein

transforming growth factor-β-inducible protein

BMP

bone morphogenetic protein

CRS

carboxylase recognition sites

dpc

days postconception

DPD

deoxypyridinoline

DHLNL

dihydroxylysinonorleucine

ECM

extracellular matrix

FAK

focal adhesion kinase

FGF

basic fibroblast growth factors

Gla

γ-carboxyglutamate

Glu

glutamate

HLNL

hydroxylysinonorleucine

LOX

lysyl oxidase

PDL

periodontal ligament

PDGF

platelet-derived growth factor

PHPT

primary hyperparathyroidism

PLF

periostin-like factor

PTH

parathyroid hormone

PTHrP

parathyroid hormone-related peptide

PYD

pyridinoline

TNFα

tumor necrosis factor α

TRAP5b

tartrate resistant acid phosphatase

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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2012

Authors and Affiliations

  1. 1.INSERM Research Unit 1033, Pavillon F, Hopital E. HerriotLyon cédex 03France
  2. 2.INSERM U 1033 and Universite Lyon 1LyonFrance
  3. 3.Cisbio BioassaysCodoletFrance

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