Osteoporosis International

, Volume 23, Issue 4, pp 1199–1212 | Cite as

The multiple facets of periostin in bone metabolism

  • B. Merle
  • P. Garnero


Periostin is a matricellular glutamate-containing protein expressed during ontogenesis and in adult connective tissues submitted to mechanical strains including bone and, more specifically, the periosteum, periodontal ligaments, tendons, heart valves, or skin. It is also expressed in neoplastic tissues, cardiovascular and fibrotic diseases, and during wound repair. Its biological functions are extensively investigated in fields such as cardiovascular physiology or oncology. Despite its initial identification in bone, investigations of periostin functions in bone-related physiopathology are less abundant. Recently, several studies have analyzed the potential role of periostin in bone biology and suggest that periostin may be an important regulator of bone formation. The aim of this article is to provide an extensive review on the implications of periostin in bone biology and its potential use in benign and metabolic bone diseases.


Bone quality Bone markers Bone metabolism Bone metastasis Periosteum 


βig-H3 protein

transforming growth factor-β-inducible protein


bone morphogenetic protein


carboxylase recognition sites


days postconception






extracellular matrix


focal adhesion kinase


basic fibroblast growth factors








lysyl oxidase


periodontal ligament


platelet-derived growth factor


primary hyperparathyroidism


periostin-like factor


parathyroid hormone


parathyroid hormone-related peptide




tumor necrosis factor α


tartrate resistant acid phosphatase



The authors would like to thank Dr. Sylvain Contie for helpful discussion on this manuscript.

Conflicts of interest



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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2012

Authors and Affiliations

  1. 1.INSERM Research Unit 1033, Pavillon F, Hopital E. HerriotLyon cédex 03France
  2. 2.INSERM U 1033 and Universite Lyon 1LyonFrance
  3. 3.Cisbio BioassaysCodoletFrance

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