Osteoporosis International

, Volume 23, Issue 10, pp 2479–2487

The 25(OH)D level needed to maintain a favorable bisphosphonate response is ≥33 ng/ml

Original Article



Why only some osteoporotic patients maintain response to prolonged bisphosphonate therapy is unknown. We examined bisphosphonate response and its association with serum 25 hydroxy vitamin D (25(OH)D) level in a “real world” setting. Serum 25(OH)D level was strongly associated with maintaining bisphosphonate response arguing that vitamin D may be involved in optimizing prolonged bisphosphonate therapy.


This study examined the maintenance of bisphosphonate response in the “real world” setting and the association between 25(OH)D and bisphosphonate response using an established composite definition of response.


Postmenopausal women with low bone mineral density (BMD) treated with bisphosphonates were identified from two New York City practices. Patients were excluded for a history of chronic steroid use, metabolic bone disease, or bisphosphonate non-adherence. Patients were categorized as bisphosphonate non-responders if they had a T-score < −3 that persisted between dual-energy X-ray absorptiometry (DEXA) scans, a >3% decrease in BMD, or an incident fracture on bisphosphonate therapy, criteria based on the EUROFORS trial. Demographic and clinical data including mean 25(OH)D levels between DEXA scans were obtained. Mean 25(OH)D levels were compared between responders and non-responders and multiple logistic regression analysis was performed to identify factors associated with non-response.


A total of 210 patients were studied. A favorable response to bisphosphonate therapy was seen in 47% (N = 99/210). Patients with a mean 25(OH)D ≥33 ng/ml had a ~4.5-fold greater odds of a favorable response (P < 0.0001). 25(OH)D level was significantly associated with response — a 1 ng/ml decrease in 25(OH)D was associated with ~5% decrease in odds of responding (odds ratio = 0.95; 95% confidence interval, 0.92–0.98; P = 0.0006).


Patients with a mean 25(OH)D ≥33 ng/ml had a substantially greater likelihood of maintaining bisphosphonate response. This threshold level of 25(OH)D is higher than that considered adequate by the Institute of Medicine, arguing that higher levels may be required for specific therapeutic outcomes.


Biphosphonates Clinical response Fracture Osteoporosis Vitamin D 

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2012

Authors and Affiliations

  • A. S. Carmel
    • 1
  • A. Shieh
    • 1
  • H. Bang
    • 2
  • R. S. Bockman
    • 1
    • 3
  1. 1.Department of Internal MedicineWeill Cornell Medical CollegeNew YorkUSA
  2. 2.Division of Biostatistics and Epidemiology, Department of Public HealthWeill Cornell Medical CollegeNew YorkUSA
  3. 3.Division of EndocrinologyHospital for Special SurgeryNew YorkUSA
  4. 4.UC-Davis, Department of Public Health SciencesDavisUSA

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