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Osteoporosis International

, Volume 22, Issue 12, pp 3037–3045 | Cite as

Fracture risk prediction using FRAX®: a 10-year follow-up survey of the Japanese Population-Based Osteoporosis (JPOS) Cohort Study

  • J. Tamaki
  • M. IkiEmail author
  • E. Kadowaki
  • Y. Sato
  • E. Kajita
  • S. Kagamimori
  • Y. Kagawa
  • H. Yoneshima
Original Article

Abstract

Summary

We evaluated the predictive ability of FRAX® in a cohort of 815 Japanese women. The observed 10-year fracture rate did not differ significantly from that predicted by FRAX®. The predictive ability of FRAX® without femoral neck bone mineral density (BMD) was similar to that with femoral neck BMD.

Introduction

We evaluated the ability of the Japanese version of FRAX®, a World Health Organization fracture risk assessment tool, to predict the 10-year probability of osteoporotic fracture.

Methods

Self-reported major osteoporotic fracture (N = 43) and hip fracture (N = 4) events were ascertained in the 10-year follow-up survey of the Japanese Population-Based Osteoporosis Cohort Study. Participants were 815 women aged 40–74 years at the baseline survey. Receiver operating characteristic curve analysis compared FRAX® with multiple logistic models based on age, body weight, and femoral neck BMD.

Results

The number of observed major osteoporotic or hip fracture events did not differ significantly from the number of events predicted by the FRAX® model (with or without BMD). The area under the curve (AUC) value for FRAX® with BMD for predicting major osteoporotic fractures was similar to that of a logistic model with age, body weight, and BMD (0.69 vs. 0.71, respectively; p = 0.198); the AUC of FRAX® with BMD for predicting hip fractures was similar to that of a model based on age and BMD (0.88 vs. 0.89, respectively; p = 0.164). The AUCs of FRAX® without BMD for predicting major osteoporotic and hip fractures were similar to those with BMD (0.69 vs. 0.67, respectively; p = 0.121; 0.88 vs. 0.86, respectively; p = 0.445).

Conclusions

The Japanese version of FRAX® without BMD estimated the 10-year probability of osteoporotic fracture in this population with few clinical risk factors as similar to that of FRAX® with BMD.

Keywords

FRAX® Japanese women Osteoporotic fracture Prospective cohort study 

Notes

Acknowledgments

This study was conducted by the JPOS Study Group, comprising Fumiaki Marumo (Chairman of the Study Group, Professor Emeritus, Tokyo Medical and Dental University), Toshihisa Matsuzaki (Co-chairman of the Study Group, Institute of Comprehensive Community Care), Tomoharu Matsukura (Kanazawa University), and Takashi Yamagami (Hokuriku Health Service Association), along with the authors. Financial support for the baseline survey was provided by the Japan Milk Promotion Board and the Japan Dairy Council. The follow-up surveys were supported by Grants-in-aid for Scientific Research (B#10470114, 1998–2000, B #14370147, 2002–2003, B#18390201, 2006–2008, and C#18590619, 2006-9) from the Japanese Society for the Promotion of Science, a grant in 2000–2002 from the Research Society for Metabolic Bone Diseases, Japan, and a Grand-in-Aid to study Milk Nutrition (2006) from the Japan Dairy Association. The authors wish to express special thanks to the personnel of the health departments of Miyako-jima City, Sanuki City, and Nishi-Aizu Town for their excellent support of the study, and to those from SRL, Tokyo, Japan; Toyo Medic, Osaka, Japan; and Toyukai Medical Corporation, Tokyo, Japan, for their technical assistance with the surveys.

Conflicts of interest

None

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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2011

Authors and Affiliations

  • J. Tamaki
    • 1
  • M. Iki
    • 1
    Email author
  • E. Kadowaki
    • 1
  • Y. Sato
    • 2
  • E. Kajita
    • 3
  • S. Kagamimori
    • 4
  • Y. Kagawa
    • 5
  • H. Yoneshima
    • 6
  1. 1.Department of Public HealthKinki University School of MedicineOsaka-sayamaJapan
  2. 2.Department of Human LifeJin-ai UniversityEchizenJapan
  3. 3.Department of Public Health and Home NursingNagoya University School of Health SciencesNagoyaJapan
  4. 4.University of ToyamaToyamaJapan
  5. 5.Kagawa Nutrition UniversityTokyoJapan
  6. 6.Shuuwa General HospitalKasukabeJapan

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