Longitudinal changes in calcaneal quantitative ultrasound measures during childhood
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This longitudinal study examined how calcaneal quantitative ultrasound (QUS) measures change during childhood while taking into account skeletal maturation, body mass index (BMI), and physical activity. The study reported sex differences in QUS growth curves and an inverse relationship between BMI and speed of sound (SOS) measures.
The aim of this study was to examine how calcaneal QUS parameters change over time during childhood and to determine what factors influence these changes.
The study sample consisted of a total of 192 Caucasian children participating in the Fels Longitudinal Study. A total of 548 calcaneal broadband ultrasound attenuation (BUA) and SOS observations were obtained between the ages of 7.6 and 18 years. The best fitting growth curves were determined using statistical methods for linear mixed effect models.
There are significant sex differences in the pattern of change in QUS parameters (p < 0.05). The relationship between QUS measures and skeletal age is best described by a cubic growth curve in boys and a linear pattern among girls. Boys experience their most rapid growth in BUA and SOS in early and late adolescence, while girls experience constant growth throughout childhood. Adiposity levels were significantly associated with the changes in SOS among boys (p < 0.001) and girls (p < 0.01), indicating that children with higher BMI are likely to have lower SOS over time compared to children with lower BMI. For girls, physical activity levels showed positive associations with changes in QUS measures (p < 0.05).
This study documents significant sex differences in the pattern of change in QUS measures over childhood and adolescence. Our study also shows significant influences of adiposity and physical activity on the pattern of change in QUS measures during childhood.
KeywordsCalcaneal quantitative ultrasound Children Longitudinal study Skeletal health
- 6.Bauer DC, Gluer CC, Cauley JA, Vogt TM, Ensrud KE, Genant HK, Black DM (1997) Broadband ultrasound attenuation predicts fractures strongly and independently of densitometry in older women. A prospective study. Study of Osteoporotic Fractures Research Group. Arch Intern Med 157:629–634PubMedCrossRefGoogle Scholar
- 9.Falcini F, Bindi G, Ermini M, Galluzzi F, Poggi G, Rossi S, Masi L, Cimaz R, Brandi ML (2000) Comparison of quantitative calcaneal ultrasound and dual energy X-ray absorptiometry in the evaluation of osteoporotic risk in children with chronic rheumatic diseases. Calcif Tissue Int 67:19–23PubMedCrossRefGoogle Scholar
- 12.van den Bergh JP, Noordam C, Ozyilmaz A, Hermus AR, Smals AG, Otten BJ (2000) Calcaneal ultrasound imaging in healthy children and adolescents: relation of the ultrasound parameters BUA and SOS to age, body weight, height, foot dimensions and pubertal stage. Osteoporos Int 11:967–976PubMedCrossRefGoogle Scholar
- 15.Baroncelli GI, Federico G, Vignolo M, Valerio G, del Puente A, Maghnie M, Baserga M, Farello G, Saggese G (2006) Cross-sectional reference data for phalangeal quantitative ultrasound from early childhood to young-adulthood according to gender, age, skeletal growth, and pubertal development. Bone 39:159–173PubMedCrossRefGoogle Scholar
- 25.Roche AF, Chumlea W, Thissen D (1988) Assessing the skeletal maturity of the hand-wrist: FELS method. Thomas, SpringfieldGoogle Scholar
- 26.Lohman T, Martorell R, Roche AF (1988) Anthropometric standardization reference manual. Human Kinetics, ChampaignGoogle Scholar
- 30.Fitzmaurice GM, Laird NM, Ware JH (2004) Applied longitudinal analysis. Wiley-Interscience, HobokenGoogle Scholar
- 32.Akaike H (1974) A new look at the statistical model identification. IEEE Trans 19:716–723Google Scholar
- 66.Kriemler S, Zahner L, Puder JJ, Braun-Fahrlander C, Schindler C, Farpour-Lambert NJ, Kranzlin M, Rizzoli R (2008) Weight-bearing bones are more sensitive to physical exercise in boys than in girls during pre- and early puberty: a cross-sectional study. Osteoporos Int 19:1749–1758PubMedCrossRefGoogle Scholar